γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status

The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever increasing. Despite decades of research, still, there is a shortage of non-toxic, safe and effective medical countermeasures for radiological and nuclear emergency. To date, the U.S. Food and Drug Administration (U.S. FDA) has approved only two growth factors, Neupogen (granulocyte colony-stimulating factor (G-CSF), filgrastim) and Neulasta (PEGylated G-CSF, pegfilgrastim) for the treatment of hematopoietic acute radiation syndrome (H-ARS) following the Animal Efficacy Rule. Promising radioprotective efficacy results of γ-tocotrienol (GT3; a member of the vitamin E family) in the mouse model encouraged its further evaluation in the nonhuman primate (NHP) model. These studies demonstrated that GT3 significantly aided the recovery of radiation-induced neutropenia and thrombocytopenia compared to the vehicle controls; these results particularly significant after exposure to 5.8 or 6.5 Gray (Gy) whole body γ-irradiation. The stimulatory effect of GT3 on neutrophils and thrombocytes (platelets) was directly and positively correlated with dose; a 75 mg/kg dose was more effective compared to 37.5 mg/kg. GT3 was also effective against 6.5 Gy whole body γ-irradiation for improving neutrophils and thrombocytes. Moreover, a single administration of GT3 without any supportive care was equivalent, in terms of improving hematopoietic recovery, to multiple doses of Neupogen and two doses of Neulasta with full supportive care (including blood products) in the NHP model. GT3 may serve as an ultimate radioprotector for use in humans, particularly for military personnel and first responders. In brief, GT3 is a promising radiation countermeasure that ought to be further developed for U.S. FDA approval for the ARS indication.     

Mutual authentication framework using fog computing in healthcare

Multimedia Tools and Applications - The development of the medical services framework is advanced by the development of the Internet of Things (IoT) innovation. There are many hindrances in the...     

Attention-based multimodal contextual fusion for sentiment and emotion classification using bidirectional LSTM

Multimedia Tools and Applications - Due to the availability of an enormous amount of multimodal content on the social web and its applications, automatic sentiment analysis, and emotion detection...     

Effect of heating and acidic pH on characteristics of wheat gluten suspension

The effects of different pH treatments with and without heating on the characteristics of wheat gluten suspension was investigated. At pH 1, maximum changes in colour were observed with a concurrent 65% decrease in protein free-thiol content compared to the control gluten. The SDS-Extractability of protein (SDS-EP) chromatogram eluted at lower retention time and the presence of bands at the top lane even during reducing conditions in SDS-PAGE gel suggested complex formation involving bonds other than disulphides. An increase in the free-amino group content and the presence of an additional peak at a higher retention time in the SDS-EP chromatogram was suggestive of hydrolysis. At pH 2 and 3, similar decreases in SDS-EPs and free-thiol content indicated formation of complexes. When heated, the free-thiol content of the dispersions increased compared to the non-heated dispersions indicating disruption of disulphide bonds with changes in gluten structure and size distribution.     

Revolutionizing supply chain management the theory of constraints way: a case study

This research describes in detail an application of theory of constraints (TOC) and its resulting benefits on the supply chain performance of India's largest lock manufacturing company over a period of seven years. Using TOC's thinking process, the core constraints that had limited the company's performance in the areas of production, distribution, supply group and projects were identified and eliminated. TOC's unique approach helped the company achieve a significant reduction in its finished goods, raw material and work-in-process inventories at various levels across the supply chain. The stock-outs and excess in the distribution system nearly disappeared. The existing lead times saw a drastic reduction while the availability of items increased to nearly 100% despite significant decrease in inventory levels in the supply chain. The inventory turns of the distributors and retailers more than tripled and their profitability increased significantly. The overall sales of the company grew nearly three times during the six years post TOC implementation. TOC's holistic approach helped the company to double its profits and improve its cash position during the Great Recession.     

Production and characterisation of bio-oil from Gold Mohar (Delonix regia) seed through pyrolysis process

Fast pyrolysis of the crushed Delonix regia seed was carried out in a semi-batch reactor at a temperature ranging from 400 to 650°C with an objective to produce bio-oil. The effect of temperature to obtain an optimum condition for maximum bio-oil yield and the composition of pyrolysis product were investigated. The maximum bio-oil yield was found to be 48?wt% at pyrolysis temperature of 600°C. The chemical composition of bio-oil obtained at optimum condition was analysed using Fourier-transformed infrared spectroscopy and Gas chromatography–mass spectrometry. The chemical analysis of the biofuel showed the presence of hydrocarbons in major, aldehydes, ketones, amides, nitriles, etc. The composition and fuel characteristics of the pyrolysis oil obtained in this work show that it may potentially be used as a renewable fuel and chemical feedstock.     

A Novel Highly Sensitive Humidity Sensor Based on ZnO/SBA‐15 Hybrid Nanocomposite

This work deals with the study of hydrothermally synthesized zinc oxide (ZnO) loaded mesoporous SBA‐15 hybrid nanocomposite for relative humidity sensing (RH) at room temperature. The sensor exhibits an excellent ~5 orders impedance change along with excellent linearity, quick response time (17 s), rapid recovery time (18 s), negligible hysteresis (1.2%), good repeatability, and stability (1.8%) in 11%–98% RH range. In addition, complex impedance spectra of the sensor at different RHs were analyzed to understand the humidity sensing mechanism. Our study can open a new way for realizing ZnO/SBA‐15 hybrid nanocomposite for fabrication of high‐performance RH sensors.     

Carbon Doping in Boron Suboxide: Structure,Energetics, and Elastic Properties

The structural, electronic, and elastic properties of pristine and carbon‐doped boron suboxide (B₆O) are calculated using density functional theory. The results indicate that it is energetically preferable for a single carbon atom to substitute into an oxygen site rather than a boron site. The lattice parameters and cell volume increase to relieve the residual stress created by the carbon substitution. The interstitial position is not favorable for a single atom substitution. However, if two carbon atoms substitute for two neighboring oxygen atoms, then it becomes energetically favorable to dope an interstitial oxygen, boron, or carbon atom along the C–C chain. If the interstitial dopant is either boron or carbon, a local B₄C‐like structure with either a C–B–C or C–C–C chain is created within the boron suboxide unit cell. The resulting structure shows improvements in the bulk modulus at the expense of the shear and Young's moduli. The moduli further improve if an additional carbon is substituted within a polar or equatorial site of the neighboring B₁₂ icosahedron. Based on these calculations, we conclude that carbon doping can either harden or soften B₆O depending on the manner in which the substitutions are populated. Furthermore, as B₆O samples are often oxygen deficient, C doping can occupy such sites and improve the elastic properties.