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71.
Zhaoxu Tu Ievgen S. Donskyi Haishi Qiao Zhonglin Zhu Wolfgang E. S. Unger Christian P. R. Hackenberger Wei Chen Mohsen Adeli Rainer Haag 《Advanced functional materials》2020,30(35)
Multidrug resistance resulting from a variety of defensive pathways in cancer has become a global concern with a considerable impact on the mortality associated with the failure of traditional chemotherapy. Therefore, further research and new therapies are required to overcome this challenge. In this work, a cyclic R10 peptide (cR10) is conjugated to polyglycerol‐covered nanographene oxide to engineer a nanoplatform for the surmounting of multidrug resistance. The nuclear translocation of the nanoplatform, facilitated by cR10 peptide, and subsequently, a laser‐triggered release of the loaded doxorubicin result in efficient anticancer activity confirmed by both in vitro and in vivo experiments. The synthesized nanoplatform with a combination of different features, including active nucleus‐targeting, high‐loading capacity, controlled release of cargo, and photothermal property, provides a new strategy for circumventing multidrug resistant cancers. 相似文献
72.
Tiesong Zhao Hanli Wang Sam Kwong C.-C. Jay Kuo Wolfgang A. Halang 《Journal of Visual Communication and Image Representation》2011,22(7):627-633
To enable robust video transmission over heterogeneous networks, the hierarchical B-picture prediction structure is employed in the state-of-the-art video coding standard H.264/SVC, aiming to produce scalable bitstreams with various frame rates. However, the exhaustive mode decision process with the hierarchical B-picture structure increases the computational complexity of H.264/SVC encoding dramatically. In this paper, a fast mode decision algorithm is proposed to speed up H.264/SVC encoding with the hierarchical B-picture structure, which is achieved by utilizing macroblock (MB) features, correlation of temporal–spatial neighboring MBs, and the discrepant characteristics of hierarchical layers. Extensive experimental results demonstrate that the proposed algorithm is able to reduce the encoding time of H.264/SVC significantly for video sequences with a wide range of resolutions, and meanwhile the video quality and compression ratio are well preserved. 相似文献
73.
Wolfgang Stadler Tilo Brodbeck Reinhold Grtner Harald Gossner 《Microelectronics Reliability》2009,49(9-11):1079-1085
Integrated circuits (ICs) are qualified for their electrostatic discharge (ESD) robustness according to the well-known IC ESD standards Human Body Model, Machine Model, and Charged Device Model in order to guarantee safe handling in ESD protected areas. For electronic systems like mobile phones which are in direct use by consumers, certain robustness against system level ESD is demanded, too. As the ESD test methods of device and system level stress are completely different (waveforms, stress application, operating condition of the DUT, etc.), correlations between models of both worlds are difficult to establish. Therefore, the system vendors more and more demand a specified ESD robustness for devices (ICs) according to an ESD system level standard. Testing ICs to a system level ESD standard requires careful considerations; first ideas are summarized in the new Standard Practice “Human Metal Model” of the ESDA/ANSI. However, the approach of deriving system ESD robustness from IC robustness is currently too much simplified and bears severe potential risks. Nevertheless, there are methodologies and approaches to use IC ESD characterization for defining ESD protection concepts for systems. Appropriate high-current characterization of ICs can be the cornerstone for a successfully optimized system ESD protection. 相似文献
74.
75.
Klaus Nolte Alexandros Kaloxylos Kostas Tsagkaris Thomas Rosowski Makis Stamatelatos Aristi Galani Eckard Bogenfeld Panagis Magdalinos Jens Tiemann Jens Gebert Paul Arnold Dirk von Hugo Nancy Alonistioti Panagiotis Demestichas Wolfgang Koenig 《International Journal of Network Management》2011,21(5):360-383
Future mobile networks are expected to be complex heterogeneous systems. On the one hand this will enable users to take advantage of a number of different access technologies. On the other hand it will seriously affect network management procedures since more extensive operations and decisions will have to be dealt with. To tackle these challenges a number of new dynamic mechanisms need to be designed. It is imperative that certain network management tasks have to be performed without human intervention to reduce the OPEX costs and achieve faster responses in different events. To achieve this goal, the introduction of self‐x functionalities, combined with cognitive mechanisms and the ability to reconfigure network entities and terminals, is required. Moreover, the introduction of a new pilot channel needs to be considered to assist the terminals in selecting the most suitable radio access technology according to their requirements. We present the functional architecture of an evolved network that was designed in the context of the EU‐funded IP project ‘E3: End‐to‐End Efficiency’. This architecture aims to enhance existing procedures usually performed in traditional operation and maintenance systems (e.g. spectrum management, network planning, configuration actions). We explain the rationale of our design and provide specific examples to illustrate the role of the different functional entities and their interfaces. A considerable part of this architecture has recently been approved as a feasibility study by the ETSI Committee Reconfigurable Radio System. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
76.
Wittmann W Wenger T Zaminer B Lueth TC 《IEEE transactions on bio-medical engineering》2011,58(10):2922-2930
Surgical navigation systems are used widely among all fields of modern medicine, including, but not limited to ENT- and maxillofacial surgery. As a fundamental prerequisite for image-guided surgery, intraoperative registration, which maps image to patient coordinates, has been subject to many studies and developments. While registration methods have evolved from invasive procedures like fixed stereotactic frames and implanted fiducial markers toward surface-based registration and noninvasive markers fixed to the patient's skin, even the most sophisticated registration techniques produce an imperfect result. Due to errors introduced during the registration process, the projection of navigated instruments into image data deviates up to several millimeter from the actual position, depending on the applied registration method and the distance between the instrument and the fiducial markers. We propose a method that allows to automatically and continually improve registration accuracy during intraoperative navigation after the actual registration process has been completed. The projections of navigated instruments into image data are inspected and validated by the navigation software. Errors in image-to-patient registration are identified by calculating intersections between the virtual instruments' axes and surfaces of hard bone tissue extracted from the patient's image data. The information gained from the identification of such registration errors is then used to improve registration accuracy by adding an additional pair of registration points at every location where an error has been detected. The proposed method was integrated into a surgical navigation system based on paired points registration with anatomical landmarks. Experiments were conducted, where registrations with deliberately misplaced point pairs were corrected with automatic error correction. Results showed an improvement in registration quality in all cases. 相似文献
77.
Phil Opitz Laura Besch Martin Panthöfer Anke Kabelitz Ronald E. Unger Franziska Emmerling Mihail Mondeshki Wolfgang Tremel 《Advanced functional materials》2021,31(3):2007830
A protein-free formation of bone-like apatite from amorphous precursors through ball-milling is reported. Mg2+ ions are crucial to achieve full amorphization of CaCO3. Mg2+ incorporation generates defects which strongly retard a recrystallization of ball-milled Mg-doped amorphous calcium carbonate (BM-aMCC), which promotes the growth of osteoblastic and endothelial cells in simulated body fluid and has no effect on endothelial cell gene expression. Ex situ snapshots of the processes revealed the reaction mechanisms. For low Mg contents (<30%) a two phase system consisting of Mg-doped amorphous calcium carbonate (ACC) and calcite “impurities” was formed. For high (>40%) Mg2+ contents, BM-aMCC follows a different crystallization path via magnesian calcite and monohydrocalcite to aragonite. While pure ACC crystallizes rapidly to calcite in aqueous media, Mg-doped ACC forms in the presence of phosphate ions bone-like hydroxycarbonate apatite (dahllite), a carbonate apatite with carbonate substitution in both type A (OH−) and type B (PO43−) sites, which grows on calcite “impurities” via heterogeneous nucleation. This process produces an endotoxin-free material and makes BM-aMCC an excellent “ion storage buffer” that promotes cell growth by stimulating cell viability and metabolism with promising applications in the treatment of bone defects and bone degenerative diseases. 相似文献
78.
环形直线行波超声电机定子的模态分析 总被引:9,自引:1,他引:9
针对一类环形封闭式的行波型直线超声电机定子的振动模态进行了有限元与实验研究。该类电机的定子由两个半圆环和两段直梁构成。分析了有限元的单元尺度对固有频率及频率差的影响以及压电陶瓷片的粘贴位置对固有频率及弯曲振型的影响。对自行研制的超声电机进行了实验研究。实验结果表明,固有频率差的数值计算值与相应的共振频率之差吻合。 相似文献
79.
Hydrogen‐Bonded Organic Semiconductors as Stable Photoelectrocatalysts for Efficient Hydrogen Peroxide Photosynthesis 下载免费PDF全文
Marie Jakešová Doǧukan Hazar Apaydin Mykhailo Sytnyk Kerstin Oppelt Wolfgang Heiss Niyazi Serdar Sariciftci Eric Daniel Głowacki 《Advanced functional materials》2016,26(29):5248-5254
Research on semiconductor photocatalysts for the conversion of solar energy into chemical fuels has been at the forefront of renewable energy technologies. Water splitting to produce H2 and CO2 reduction to hydrocarbons are the two prominent approaches. A lesser‐known process, the conversion of solar energy into the versatile high‐energy product H2O2 via reduction of O2 has been proposed as an alternative concept. Semiconductor photoelectrodes for the direct photosynthesis of H2O2 from O2 have not been applied up to now. Photoelectrocatalytic oxygen reduction to peroxides in aqueous electrolytes by hydrogen‐bonded organic semiconductor is observed photoelectrodes. These materials have been found to be remarkably stable operating in a photoelectrochemical cell converting light into H2O2 under constant illumination for at least several days, functioning in a pH range from 1 to 12. This is the first report of a semiconductor photoelectrode for H2O2 production, with catalytic performance exceeding prior reports on photocatalysts by one to two orders of magnitude in terms of peroxide yield/catalyst amount/time. The combination of a strongly reducing conduction band energy level with stability in aqueous electrolytes opens new avenues for this widely available materials class in the field of photo(electro) catalysis. 相似文献
80.
We demonstrated top-gate organic field effect transistors (OFETs) made with free radical photo-cured polymer gate dielectrics and poly(3-hexylthiophene). We introduced a new approach of cross linking dielectric polymers in OFETs by using acrylate monomers cured with UV irradiation directly on the semiconductor. Three different blends were formulated: one self-initiating acrylate oligomer and two epoxy acrylate monomers mixed with 4-phenylbenzophenone as photo initiator and N-methyldiethanolamine as amine synergist. Thin films of these blends were cured in air within one minute. The curing process was monitored with FT-IR spectroscopy and the effect of a wetting agent was studied by measuring the CV characteristics of metal–insulator-semiconductor (MIS) structures made with these formulations. OFETs made with the demonstrated formulations showed high on/off ratios (105–106) and low sub-threshold slopes (0.44–1.42 V/dec). 相似文献