Overexpression of amyloid precursor protein of Alzheimer's type in brains of intoxicated children

The coincidence of neuronal stress induced by intoxication and an overexpression of amyloid precursor protein (APP) in the brains of children was examined. Brains of ten children accidentally intoxicated by poisonous mushroom were studied by means of immunohistochemical methods using monoclonal antibodies generated against different domains of APP and glial cell markers. Overexpression of APP was found in the brain neurons of all intoxicated children. Neurons were immunopositive with the antibodies generated against the middle (amyloid beta protein) domain of APP. No extracellular deposits were found in the tissue. Our results provided, for the first time, the evidence that overexpression of APP concomitant with the neuronal stress is age-independent phenomenon appearing not only in the brain of adults but in very young individuals as well.     

矿井串联系统模糊可靠性理论的研究

矿井系统不仅具有随机性，而且同时也具有模糊性，在系统分析与设计过程中应同时考虑这两种不确定性因素的影响。文中提出了模糊故障、模糊功能、系统模糊运营状态和广义可靠度等概念，并在此基础上提出了求单元及串联系统的生产能力、营运费用、应急维修费用、修理时间和广义可靠度等指标的方法，建立了使系统平均生产能力最大的系统最优运营策略的数学模型。     

全金属反射光学系统结构的有限元分析

用有限元分析方法对全金属反射光学系统在各种受力状态下的变形、应力及固有频率做了全面的分析，并给出了结构多次优化后的分析结果。     

X荧光光谱法测定不锈钢的研究

本文论述了Ｘ荧光光谱测定高铬钢和不锈钢的分析方法，用理论α系数校正基体效应和用谱线干扰系数Ｌ校正谱线重叠影响。方法准确度和精度令人满意，操作十分简便、快速。     

Performance implications of the thermal-induced frequency drift infast wavelength switched systems with heterodyne detection

The frequency modulation response and tuning dynamics of a two-section DFB laser are determined by carrier and thermal modulation of the active layer refractive index. In response to a step change in the injection current for switching between channels in a wavelength division multiplexed system, the optical frequency changes rapidly due to the carrier effect, and then slowly drifts toward a steady state value due to the thermal effect. For wavelength switched applications with heterodyne detection, the drifting of the optical frequency broadens the spectrum of the IF signal and may impose a limit on the time that the signal remains within the IF passband (residency time). The IF spectral broadening and residency time are investigated theoretically and experimentally. Based upon a minimum mean square error fit between experimental and theoretical FM responses, the dependence of the spectral broadening and residency time on the bias condition of the laser and the optical frequency switching interval is characterized     

折线滑面滑体的稳定分析方法的改进

本文根据刚体极限平衡分析原理，考虑各块体的力矩平衡和块间的嵌合作用，假定作用于块体的已知外力所产生的应力呈线性分布，推导出确定其作用力数值、方向和作用点，以及整体抗滑稳定安全系数的方法和公式。并通过实用研究了嵌合作用、分界面倾角等对反力分布和安全系数的影响，与常用方法的计算结果作了比较，说明本方法有较大的适用性，可应用于工程设计。     

FAST MEASUREMENT OF ASH CONTENT IN COAL WASHING PLANT

The coal filter cake is a product of fine coal after floatation which has an ash content of 7-13%, water content of 30±2%, and a particle size of less than 1 mm. The ash content was measured by the intensity of the single backscattered gamma-ray, and its accuracy is mainly dependent on the energy of the gamma-ray. The 238Pu low energy photon source is selected in this work. The energy of its gamma-ray is 15 keV, which can result not only in the best sensitivity, but also in the lowest contribution to the environment radiation. The root mean square deviation of the ash measurement is±0.33% (±1σ).     

提高大口径金属主镜面形精度的方法

分析了影响Ｒｉｔｃｈｅｙ－Ｃｈｒｅｉｔｉｅｎ光学系统中金属主反射镜面形精度因素，采用有限元法对立交易的加工过程及其安装进行了模拟，指出提高主镜的面形镜度，既要合理主镜材料的热处理工艺，也要对加工参数进行控制。良好的稳定化处理可以有效地消除材料内部的残余应力，保证主镜尺寸的稳定性。提高加工基准的精度，并采用组合加工镜面，可以大大提高主镜的面形精度，最后，给出了主镜的干涉仪检测结果。     

提高润滑油基础油氧化安定性的组合工艺

以生产润滑油基础油的老三套工艺为基础，开发了改善油品氧化安定性的组合工艺。该工艺的主要特点是包括一步络合脱氮过程。实验证明，该组合工艺既可以有效地提高基础油的氧化安定性，又能降低溶剂精制深度，提高基础油收率。