Requirement of cysteine-rich repeats of the Fas receptor for binding by the Fas ligand

The Fas receptor is a member of a family of cell death receptors, including tumor necrosis factor receptor I (TNFR I), death receptor 3 and 4 (DR3 and DR4), and cytopathic avian receptor 1 (CAR1). The Fas receptor is composed of several discrete domains, including three cysteine-rich domains (CRDs), a transmembrane domain, and an intracellular domain responsible for transmitting an apoptotic signal. While the mechanism of Fas-mediated cell death has become elucidated, the requirements for Fas ligand binding to the receptor have not been fully defined. Using a series of chimeric Fc-receptor fusion proteins between the human Fas receptor and TNFR I, each cysteine-rich domain of Fas was found to be required for interaction with the Fas ligand. Interestingly, TNFR I CRD1 could partially substitute for the Fas CRD1. The importance of this domain was underscored by the analysis of a Fas extracellular mutation (C66R), which resulted in a complete loss of ligand binding. This mutation was cloned from a human patient suffering from Canale-Smith syndrome, which is characterized by autoimmunity resembling that observed in the lpr and lprcg mice. The localization of essential ligand binding domains in the Fas receptor correlated exactly with the ability of the Fas receptor fusion proteins to prevent cell death mediated by the Fas ligand.     

An extraction method to determine interconnect parasitic parameters

Interconnect parasitic parameters in integrated circuits have significant impact on circuit speed. An accurate monitoring of these parameters can help to improve interconnect performance during process development, provide information for circuit design, or give useful reference for circuit failure analysis. Existing extraction methods either are destructive (such as SEM measurement) or can determine only partial parasitic parameters (such as large capacitor measurement). In this paper, we present a new method for extracting interconnect parasitic parameters, which can simultaneously determine the interlayer and intralayer capacitances, line resistance, and effective line width. The method is based on two test patterns of the same structure with different dimensions. The structure consumes less wafer area than existing methods. The method shows good agreement with SEM measurement of dielectric thickness in both nonglobal planarized and chemical-mechanical polished processes, and gives accurate prediction of the process spread of a ring oscillator speed over a wafer     

分离有机/有机混合物的PVA、CA系列膜及其渗透汽化性能研究(Ⅱ) 成膜条件对渗透汽化性能的影响

用溶剂完全蒸发法制备了PVA复合膜 .经对MTBE/MeOH混合物的分离实验得到了PVA复合膜的最佳成膜条件 ,即 :铸膜液中PVA、马来酸浓度分别为 7%、3% ,热处理温度130～ 15 0℃ .在 1%～ 2 %丙酮水溶液中浸泡处理 4～ 8h ,CTA中空纤维RO膜被改性成渗透汽化膜 .CTA中空纤维膜的分离性能优于其它醋酸纤维素系列膜 ,PVA/CA复合膜的性能优于PVA/PAN复合膜和CA/PAN复合膜     

CTS-26型超声探伤仪典型故障的分析与排除

在简要介绍CTS-26型超声探伤仪工作原理及组成的基础上。对其几种典型故障作了具体的分析和处理。     

气囊内模制作桥面板在华丰湾防洪工程中的应用

采用气囊作内模进行浇筑桥面板混凝土 ,加快了预制桥面板施工进度 ,确保工程施工质量 ,并降低了工程施工成本     

铝带材冷轧机机前展平辊重叠量的探讨

目前国内大多数铝加工厂对铝带材冷轧机机前展平辊的作用缺乏足够的认识，甚至弃而不用。本文主要论述展平辊的作用及展平辊重叠量的计算方法。     

变频器联网监控系统

用网络实现对变频器群监控,通过MSComm控件实现软件功能。     

军械调运方案优化算法的设计与仿真

军械调运问题的数学模型和手工算法过去已有研究,但是当问题较为复杂时,手工算法就要花费大量时间而且准确性也难以保证。针对这一缺陷,本文在已有的数学模型和手工算法的基础上,设计了一种可以用计算机实现的基于递归的算法来寻求军械紧急调运问题的最优方案,并使用面向对象的java语言将算法实现。     

SiCf/O′-SiAlON composite: properties and oxidation retained properties

A composite of O′SiAlON (Si_2-xAl_xN_2-xO_1+x, with x 0.14) reinforced with 20 vol.% SiC monofilaments was fabricated by hot-pressing, at 1600°C, for 2 h under 34 MPa pressure. The mechanical and interfacial properties of the composites, as-fabricated as well as post-oxidized, were, investigated. The composite exhibited a significant improvement in ultimate flexure strength (640 MPa) and work of fracture (42 kJ m⁻²) compared with that (350 MPa and 1.8 kJ m⁻², respectively) of the monolithic material. These mechanical properties were slightly increased after the composite was heat treated for 24 h in air at 1200 and 1300°C. However, the composite exhibited a significant degradation in ultimate strength, while the work of fracture (WOF) remained unchanged after exposure in air at temperatures beyond 1400°C. The as-fabricated composite revealed a low interfacial shear strength (6.2 MPa) and a frictional sliding stress (3.2 MPa). After the composite was oxidized at elevated temperatures, the interfacial bonding and sliding stresses were reduced to noticeable extents, resulting from the degradation of the carbon coating layer of the SiC monofilaments.