FSE–Ag complex NS: preparation and evaluation of antibacterial activity

Silver (Ag) complexes of drugs and their nanosystems have great potential as antibacterials. Recently, an Ag complex of furosemide (Ag–FSE) has shown to be a promising antimicrobial. However, poor solubility of Ag–FSE could hamper its introduction into clinics. Therefore, the authors developed a nanosuspension of Ag–FSE (Ag–FSE_NS) for its solubility and antibacterial activity enhancement. The aim of this study was to introduce a novel nanoantibiotic with enhanced antibacterial efficacy. Ag–FSE_NS was prepared by precipitation–ultrasonication technique. Size, polydispersity index (PI) and zeta potential (ZP) of prepared Ag–FSE_NS were measured by dynamic light scattering, whereas surface morphology was determined using scanning electron microscopy (SEM). In vitro antibacterial activity was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa using broth microdilution method. Size, PI and ZP of optimised Ag–FSE_NS1 were 191.2 ± 19.34 nm, 0.465 ± 0.059 and −55.7 ± 8.18 mV, respectively. SEM revealed that Ag–FSE_NS1 particles were rod or needle‐like with smooth surfaces. Saturation solubility of Ag–FSE in NS increased eight‐fold than pure Ag–FSE. Ag–FSE_NS1 exhibited two‐fold and eight‐fold enhancements in activity against E. coli and S. aureus, respectively. The results obtained showed that developed Ag–FSE_NS1 holds a promise as a topical antibacterial.Inspec keywords: nanomedicine, nanofabrication, light scattering, surface morphology, silver, particle size, solubility, suspensions, scanning electron microscopy, electrokinetic effects, drugs, biomedical materials, antibacterial activity, microorganisms, nanoparticles, drug delivery systems, transmission electron microscopyOther keywords: saturation solubility, topical antibacterial, size 171.86 nm to 210.54 nm, voltage ‐47.52 mV to ‐63.88 mV, Ag, broth microdilution method, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, SEM, scanning electron microscopy, surface morphology, dynamic light scattering, particle size, polydispersity index, precipitation–ultrasonication technique, nanoantibiotic, nanosuspension, furosemide, nanosystems, drugs, Ag–FSE_NS preparation, in vitro antibacterial activity, pure Ag–FSE, Ag–FSE_NS1 particles, optimised Ag–FSE_NS1, zeta potential, enhanced antibacterial efficacy, antibacterials     

MapX在导弹作战想定态势图的应用与实现

针对某战术导弹训练系统中实现导弹作战过程可视化的要求,在分析MapX功能特性的基础上,应用MapX组件技术在VC++环境上实现了导弹作战过程飞机及导弹飞行轨迹态势图的绘制.结合态势图中真实地理信息下航迹显示功能的实现,重点阐述了MapX中图层绘制技术的应用.     

基于奇异值分解的稀疏重构近场声源定位*

针对近场声源定位问题,提出一种基于奇异值分解的稀疏重构定位方法。该方法通过奇异值分解得到信号子空间,然后在信号子空间约束l₁范数求解优化问题实现声源的定位。与直接对接收信号进行稀疏重构相比,该方法通过奇异值分解降低了计算量,有效抑制了噪声。仿真结果表明,与子空间方法相比,提高了定位的抗噪声性能和分辨率。     

基于数据块的关系数据库日志挖掘技术

在关系型数据库中数据库通过Redo日志来实现事物的快速提交,并记录事物的操作过程与操作内容.通过对Redo日志的分析与变化数据内容的捕获,将变化数据传送到灾备端,并在灾备端实现变化数据的写入,是目前数据库复制最主要实现原理.本文分析了oralce数据库Redo日志文件结构,阐述了日志文件头标志位信息.结合Redo 日志文件头定位分析技术,给出了一种基于数据块的数据库Redo日志挖掘算法.通过测试分析,验证了该Redo日志挖掘技术的可行性与可靠性.最后展望了下一步的研究方向.     

Product selection for promotion planning

This paper addresses a very important question—how to select the right products to promote in order to maximize promotional benefit. We set up a framework to incorporate promotion decisions into the data-mining process, formulate the profit maximization problem as an optimization problem, and propose a heuristic search solution to discover the right products to promote. Moreover, we are able to get access to real supermarket data and apply our solution to help achieve higher profits. Our experimental results on both synthetic data and real supermarket data demonstrate that our framework and method are highly effective and can potentially bring huge profit gains to a marketing campaign.     

基于ASP网站的安全防范

随着计算机技术和网络技术的发展,ASP(Active Server Pages)作为一种典型的服务器端网页设计技术,被广泛地应用在各种互联网应用中。而动态网的安全问题日益突显,安全问题备受关注。该文先分析了ASP动态网存在的安全隐患,然后针对这些安全隐患,提出了相应的安全保护方案,从而为网站的数据安全提供保障。     

古琉璃与现代玻璃艺术的继承与创新——从中国玻璃艺术史的角度谈

论文首先对中国古玻璃①艺术形式进行分析,从宏观上对中国古代玻璃技术的发展进行整体阐述,指出古代中国的玻璃行业发展缓慢的原因和现代玻璃艺术的出现与大发展。本文着重于从玻璃艺术工艺入手,解析历史中的工艺形态、技术应用现象,结合其工艺自身的特点和艺术的形式规律,对传统工艺的再开发,挖掘其潜力为今天服务。现代的工艺形式是基于古老的传统技术手法之上的,是传统工艺的延续和变革。     

Combining genetic approach and integer programming to solve multi-facility economic lot-scheduling problem

Economic lot-scheduling problem (ELSP) has been studied since the 1950??s. ELSP deals with the scheduling of the production of several items on a single facility in a cyclical pattern. The facility can only produce one single item at a time, and there is a set-up cost and set-up time associated with each item. Because of the rapid development of many emerging markets nowadays, many common items are produced in different places in order to satisfy the demands in different markets. This becomes the multi-facilities ELSP problems. In ELSP problems, it is known that if more items types to be produced by the facility, the production frequency of each item type will increase because of the balancing of the production rate and the demand rate. Consequently, the number of set-up time and set-up cost increases accordingly. Thus, reallocating the common items, which can be produced in any facilities, to be produced only on certain facility can certainly reduce the number of production frequency, and lead to lower related costs. The objective of this paper is to propose an optimization methodology combining Integer Programming and Genetic Algorithm to solve multi-facility ELSP problems. This paper proposes to divide the main problem into a master problem and sub-problems, which are solved by Integer Programming and Genetic Algorithm respectively. To demonstrate the significance of reallocating the common items and aggregating them to produce in certain facility, several models have been designed and tested. The comparison of the models demonstrates the reduction of the costs benefited by result of common items reallocation.     

改进D-P算法在图像轮廓平滑中的应用

针对传统D-P算法速度较慢、编程不方便的问题,提出一种改进算法。以一定步长对轮廓进行遍历,根据轮廓上点到所选轮廓段首末点连线最大距离与距离阈值的大小关系,按轮廓遍历顺序获取曲线轮廓的特征点,并在相邻的特征点之间采用贝塞尔曲线进行平滑。实验结果表明,改进算法的速度比传统算法提高10%以上。