Single-step assembly of polymer-lipid hybrid nanoparticles for mitomycin C delivery

Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 to 101) and biodegradable polylactic acid (PLA) polymers for intravenous MMC delivery. The advantage of the MMC-SPC complex on the polymer-lipid hybrid NPs was that MMC-SPC was used as a structural element to offer the integrity of the hybrid NPs, served as a drug preparation to increase the effectiveness and safety and control the release of MMC, and acted as an emulsifier to facilitate and stabilize the formation. Compared to the PLA NPs/MMC, the PLA NPs/MMC-SPC showed a significant accumulation of MMC in the nuclei as the action site of MMC. The PLA NPs/MMC-SPC also exhibited a significantly higher anticancer effect compared to the PLA NPs/MMC or free MMC injection in vitro and in vivo. These results suggested that the MMC-loaded polymer-lipid hybrid NPs might be useful and efficient drug delivery systems for widening the therapeutic window of MMC and bringing the clinical use of MMC one step closer to reality.     

CuAlCl4 doped MIL-101 as a high capacity CO adsorbent with selectivity over N2

A CuAlCl₄ doped metal organic framework, CuAlCl₄@MIL-101, was prepared by introducing CuAlCl₄ into the pores of MIL-101 for the selective adsorption of CO over N₂. The CuAlCl₄ molecules were evenly distributed into various pores sizes and did not change the intrinsic structure of the MIL-101. Isotherms for CO and N₂ adsorption at 298 K showed that the CO capacity on CuAlCl₄@MIL-101 was much higher than that on virgin MIL-101, whereas the N₂ capacity decreased. The selectivity for CO over N₂ improved from 4.64 to 31.5 at 298 K and 1 bar. The CuAlCl₄@MIL-101 adsorbent displayed outstanding CO adsorption stability and the adsorbent could be regenerated by applying a simple vacuum of 4 mmHg.     

陶瓷粉末的固态复分解反应合成

本文扼要地介绍了固态复分解反应法制备陶瓷粉末的基本原理、关键技术、特点及其研究进展。     

Effect of defects of the domain structure on the optical properties of ferroelectric crystals

The effect of irregularities of a periodic domain structure on the efficiency of the second harmonic generation has been numerically investigated in the case where the structure is formed by the high-voltage method. The irregularities associated with the uncontrollable motion of domain walls from under electrodes, as well as with the presence of internal defects in the crystal, have been analyzed.     

Effect of mechanical activation on thermal explosion in Ni-Al mixtures

The effect of mechanical activation (MA) on thermal explosion in equimolar Ni-Al mixtures was studied by time-resolved XRD. MA was also found to increase the burning velocity and decrease the ignition temperature. Thermal explosion in non-activated Ni-Al mixtures was found to proceed via formation of liquid (melted) intermediate products, while that in the activated mixtures gave no liquid intermediates.     

Distribution of mineral components in the hydrothermal-processing products of sapropelite organic mass

The hydrothermal treatment of sapropelite is investigated, to establish the distribution of mineral components in the decomposition products. In hydrothermal pyrolysis, an organic-mineral mixture is obtained. The mineral components may be extracted from this mixture. The results suggest that the carboxylic acids obtained from hydrothermal treatment of sapropelite have valuable extractive properties. The characteristic reactions for the carboxylic acids are substitution reactions, with the formation of salts of various metals.     

Radioactivity of coal and ash

The radioactivity of Kuznetsk Basin coal and ash is considered, in relation to other regions.     

Coal mining in the Russian Donetsk Basin

The activities of coal companies in the Russian Donetsk Basin (Rostov oblast) are considered, as well as the basic coal characteristics, the potential value of local reserves, and the prospects for the region in current economic conditions.     

Reducing the phenol content in coal tar and in coke-plant water flows

The influence of coking-product pyrolysis within the coke furnace on the phenol content in coal tar and in the water in the gas-collection cycle and at the biochemical-treatment unit is considered.     

More efficient operation of the dust-free coke-discharge modules at OAO Zaporozhkoks coke batteries 5 and 6

Two types of dust-free coke-discharge modules are generally employed. The modules employed at OAO Zaporozhkoks are described and analyzed. Methods are proposed for determining their operational efficiency and testing their performance in plant conditions. Recommendations are made for improving the operational efficiency of dust-free coke-discharge modules mounted on door-opening machines.