A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures

It is believed that DOPA-negative melanocytes in the outer root sheath of the human hair follicle are activated, become identifiable by DOPA staining, and migrate into the epidermis during the repigmenting phase of vitiligo. These cells are difficult to identify, however, and otherwise have not been characterized. These cells are readily identified by immunofluorescence, immunohistochemistry, and immunoelectronmicroscopy using the antibodies NKI/beteb and A4F11, which recognize premelanosome-related antigens. The majority of the outer root sheath melanocytes were found in the mid to the upper portion of the hair follicle. Double staining revealed that these cells were distinct from HLA-DR-bearing dendritic cells. Further immunohistochemical investigation using alpha-PEP-7, alpha-PEP-1, or TMH-1 and alpha-PEP-8 antibodies revealed that outer root sheath melanocytes cannot be identified by antibodies to tyrosinase, TRP-1, or TRP-2, respectively. These cells also did not react with HMB45 antibody, which recognizes a melanosome-associated cytoplasmic antigen. We believe that the inactive outer root sheath melanocytes contain some of the early structural proteins but not any of the enzymatic proteins necessary for melanogenesis. Therefore, activation is the process whereby outer root sheath melanocytes acquire all of the structural and enzymatic proteins necessary for melanogenesis.     

SIR-C data quality and calibration results

The SIR-C/X-SAR imaging radar took its first flight on the Space Shuttle Endeavour in April 1994 and flew for a second time in October 1994. This multifrequency radar has fully polarimetric capability at L- and C-band, and a single polarization at X-band (X-SAR). The Endeavour missions were designated the Space Radar Laboratory-1 (SRL-1) and -2 (SRL-2). Calibration of polarimetric L- and C-band data for all the different modes SIR-C offers is an especially complicated problem. The solution involves extensive analysis of pre-flight test data to come up with a model of the system, analysis of in-flight test data to determine the antenna pattern and gains of the system during operation, and analysis of data from over fourteen calibration sites distributed around the SIR-C/X-SAR orbit track. The SRL missions were the first time a multifrequency polarimetric imaging radar employing a phased array antenna has been flown in space. Calibration of SIR-C data products involved some unique technical problems given the complexity of the radar system. In this paper, the approach adopted for calibration of SIR-C data is described and the calibration performance of the data products is presented     

Dichotomous behavior of polymer melts in isothermal melt spinning

Isothermal melt spinning experiments have been conducted using two polyethylene melts of low density (LDPE) and high density (HDPE) to produce steady state spinline profiles. The data revealed the threadline extensional viscosity exhibiting a contrasting picture : extension thickening behavior for LDPE and extension thinning one for HDPE. A White-Metzner model having a strain rate-dependent relaxation time was then found to be able to simulate this dichotomy in melt spinning fairly well: the fluids whose relaxation times have smaller strain rate-dependence can fit LDPE data with extension thickening extensional viscosity whereas the fluids whose relaxation times have larger strain rate-dependence can fit HDPE data with extension thinning extensional viscosity. This dichotomous nature of viscoelastic fluids is also believed to be able to explain other similar contrasting phenomena exhibited by polymer melts, such as vortex/no vortex in entry flows, cohesive/ductile fracture modes in extension, and more/less stable draw resonance than Newtonian fluids.     

球状碳单质分子的发现,研究现状及应用前景

综述了碳的第三种同素异形体──球状碳单质分子的发现、结构、性质及其应用前景。     

Expert system approach for reactor vessel integrity

This paper describes the development strategy of a prototype expert system, called RViES, for the reactor vessel integrity. The main objectives of the system are to assist engineers to perform fatigue and fracture mechanics analyses of reactor vessels quickly and accurately. The system consists of three parts; user interface, knowledge base and inference engine. Various rules recommended in codes and standards are stored in the knowledge base. Several case studies were performed to check the usefulness of the system.     

Visual discrimination on colour VDTs at two viewing distances

The paper describes a research study on visual discrimination of textual and graphic symbols on a visual display terminal (VDT) screen when viewed at eye-lo-screen distances of 61 cm and 152 cm (24 and 60 ins). Conducted as part of a development programme at McDonnell Douglas Corporation's St. Louis Aircraft Company for an Integrated Manufacturing Composites Centre (ICC), the study investigated symbol shapes, symbol sizes, symbol colours and background colours at the two viewing distances. The longer distance is representative of required placements of the VDTs at some manufacturing workstations to avoid interference with process or control equipment. Knowledge gained from the study was incorporated in the selection of the manufacturing computer information system (CIS) terminals.

All four treatments showed significant effects on visual discrimination at both viewing distances and, particularly at the 152 cm distance, the mix of symbol and background colours was highly significant. A black screen background colour with more luminous symbols such as orange, green, yellow provided much better visual discrimination at the extended viewing distance than less luminous symbols such as red and blue on a white background. Visual discrimination at the extended viewing distance, when compared with the shorter viewing distance and using symbols of equal size, was better than the loss in visual angle would suggest.

Sex and age (to age 65) did not significantly affect visual discrimination mean scores, but the variance among individuals in the 51-65 years age group was greater than for the younger age groups.

The visual discrimination scores for symbol sizes of 4 mm² were not significantly different from the 6 mm² symbols at the 61 cm viewing distance. The 4 mm² symbol size was therefore adequate for visual discrimination of standalone symbols at this distance. Although 8 mm symbols were not used in this study, projections from the data indicate that such symbol sizes at 152 cm would provide comparable discrimination scores to the 4 mm² at 61 cm.

Improved visual discrimination of standalone symbols occurs with gaps or changes in the angles of symbols, such as sets 'C' versus 'O' and 'Xl' versus'+'.     

LiMn2O4纳米粉的湿化学合成与表征

采用湿化学方法，通过水溶液中的化学反应直接合成纳米级LiMn2O4化合物，其结构基本上为无定型，但XRD图谱中已出现LiMn2O4特征峰，说明在水溶液中已初步形成尖晶石结构，运用XRD，SEM，TG－DTA等现代检测手段对样品的性能进行进行了表征，XRD及SEM等分析结果表明，合成样品经简单热处理后，晶型结构完善，形貌规整，均匀，比表面积积显著减小，粒度明显变粗。TG－DTA热分析证明，样品在低于900℃的温度下进行热处理时，仅发生LiMn2O4的晶化过程，产物的化学组成稳定，该法合成锂离子电池正极材料LiMn2O4，具有工艺流程简单，产物的成分，结构及粒度均匀等特点。     

On-Line File Caching

Abstract. Consider the following file caching problem: in response to a sequence of requests for files, where each file has a specified size and retrieval cost , maintain a cache of files of total size at most some specified k so as to minimize the total retrieval cost. Specifically, when a requested file is not in the cache, bring it into the cache and pay the retrieval cost, and remove other files from the cache so that the total size of files remaining in the cache is at most k . This problem generalizes previous paging and caching problems by allowing objects of arbitrary size and cost, both important attributes when caching files for world-wide-web browsers, servers, and proxies. We give a simple deterministic on-line algorithm that generalizes many well-known paging and weighted-caching strategies, including least-recently-used, first-in-first-out, flush-when-full, and the balance algorithm. On any request sequence, the total cost incurred by the algorithm is at most k/(k-h+1) times the minimum possible using a cache of size h ≤ k . For any algorithm satisfying the latter bound, we show it is also the case that for most choices of k , the retrieval cost is either insignificant or at most a constant (independent of k ) times the optimum. This helps explain why competitive ratios of many on-line paging algorithms have been typically observed to be constant in practice.