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The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 under the dose of 100 mg/kg increased the signal intensity of NOFe2+(DETC)2 complex, while EGb 761 at 200 mg/kg showed an effect of decreasing the signal intensity of NOFe2+(DETC)2 complex. EGb 761 inhibited the formation of TBARS, the release of CK, and mitigated the incidence of ventricular arrhythmias in a dose dependent way. Both l-arginine and SOD increased the signal intensity of NOFe2+(DETC)2 complex and inhibited the formation of TBARS, the leakage of CK and the incidence of ventricular arrhythmia. NNA not only had no protective effects on myocardial injury, but also increased the incidence of reperfusion-induced arrhythmia. In conclusion, EGb 761 has cardiovascular protective effects by means of adjusting the level of NO and inhibiting oxygen free radicals induced lipid peroxidation in myocardial ischemia-reperfusion injury in vivo. 相似文献
56.
在30CrMnSiA钢中加入不同量的As,Sb,Sn元素,研究了这些元素单独存在及复合存在时对钢的强度,塑性,冲击韧度及韧脆转变温度的影响规律,并用扫描电镜及俄歇能谱分析了As,Sb,Sn导致晶界脆化的机理。 相似文献
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赵勋 《计算机光盘软件与应用》2012,(3):3+11
本文主要介绍RFDI技术定义及系统工作原理,并重点关注RFID技术在智能交通领域的实际应用方式。同时RFID技术也成功解决了车辆自动识别和信息采集问题,为智能交通管理和服务系统的建立提供了强大的信息支撑和保障。 相似文献
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The characterization of La
x
Sr1−x
MnO3 powders produced by spray pyrolysis using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observation,
specific surface area (Brunauer-Emett-Teller), and particle size distribution measurements shows that the resultant large
particles are loose agglomerates consisting of many small particles. However, the sintered tiny particles can form hard agglomerates,
and the particle size increases remarkably. The structures of the powders before and after sintering were identified by x-ray
diffraction (XRD). The study of the electrical property of the powder shows that the powder is a metallic conductor. In a
reducing atmosphere, the powder can be decomposed. When the powder is cofired with yttria-stabilized zirconia 5% (YSZ) powder
at 1200 °C for 5 h, no new phase is produced, and the powder remains a single provskite hexagonal-rhombohedral structure. 相似文献
60.
Pipelines and heat exchangers using seawater as coolant suffer from biofouling. Biofouling not only reduces heat transfer performance significantly, but also causes considerable pressure drop, calling for higher pumping requirements. It would be much more desirable if surfaces with an inherently lower stickability for biofouling could be developed. In this paper, a cost-effective autocatalytic graded Ni-Cu-P-PTFE composite coating with corrosion-resistant properties was applied to reduce biofouling formation. The experimental results showed that the surface free energy of the Ni-Cu-P-PTFE coatings, which were altered by changing the PTFE content in the coatings, had a significant influence on the adhesion of microbial and mineral deposits. The Ni-Cu-P-PTFE coatings with defined surface free energy reduced the adhesion of these deposits significantly. The anti-bacterial mechanism of the composite coatings was explained with the extended DLVO theory. 相似文献