Hot-rolling simulation and modelling using Gleeble 1500

Using the Gleeble 1500, incremental and continuous hot compression tests, simulating hot rolling, were performed on C-Mn, Nb-T, and Nb steels with test temperatures varying between 875 and 1100°C and strain rates between 0.5 and 20 s^?1. Four models are proposed. The stress peak model allows the prediction of continuous stress-strain curves from incremental curves and vice versa through the use of stress restoration index K. Variation in K for Nb-T₁, C-Mn and Nb steels at strain rates of 3, 12 and 20 s^?1 was found to be negligible. The predicted stress strain curve corresponds to experimental stress strain curve at same temperature and strain rate. The strain history model predicts continuous strain-time curves from incremental stress-strain curves using ‘constant’ ‘negative strain’ restoration index. At 950°C, with holding time 2 s and strain rate 12 s^?1, strain time decay curves obtained for C-Mn, Nb and Nb-T, steels were ε = 1.5e^?05t, ε = 1.2e^?0.36t and ε = e^?0.3t, respectively. The creep model analysis relates creep strain rate to the testing strain rate. For Nb steel at 875°C, and test strain rate of 12 s^?1, ?_creep was found to be 9.5 s^?1. The stress history model predicts continuous stress-time curves from incremental stress-time curves. Stress decay curve for C-Mn steel at 1100°C and ? = 3s^?1 was found to be σ = 181e^?0.04t. Hot rolling characteristics of steels can be accurately predicted using hot compression tests and proposed models.     

EON: a component-based approach to automation of protocol-directed therapy

Provision of automated support for planning protocol-directed therapy requires a computer program to take as input clinical data stored in an electronic patient-record system and to generate as output recommendations for therapeutic interventions and laboratory testing that are defined by applicable protocols. This paper presents a synthesis of research carried out at Stanford University to model the therapy-planning task and to demonstrate a component-based architecture for building protocol-based decision-support systems. We have constructed general-purpose software components that (1) interpret abstract protocol specifications to construct appropriate patient-specific treatment plans; (2) infer from time-stamped patient data higher-level, interval-based, abstract concepts; (3) perform time-oriented queries on a time-oriented patient database; and (4) allow acquisition and maintenance of protocol knowledge in a manner that facilitates efficient processing both by humans and by computers. We have implemented these components in a computer system known as EON. Each of the components has been developed, evaluated, and reported independently. We have evaluated the integration of the components as a composite architecture by implementing T-HELPER, a computer-based patient-record system that uses EON to offer advice regarding the management of patients who are following clinical trial protocols for AIDS or HIV infection. A test of the reuse of the software components in a different clinical domain demonstrated rapid development of a prototype application to support protocol-based care of patients who have breast cancer.     

Botulinum toxin for neurological disorders in a movement disorders clinic in Singapore

AIM OF STUDY: This study was done to examine the usefulness of botulinum toxin A injections in treating various neurological disorders such as hemifacial spasm, blepharospasm, focal dystonia and task-specific dystonia. METHODS: This was a prospective, open-labelled trial of patients seen in a Movement Disorders Clinic with dyskinesias potentially treatable with botulinum toxin. All patients were assessed before and after injections using clinical rating scales, and those with focal and task-specific dystonias were also recorded on videotape. RESULTS: There were 102 patients with hemifacial spasm, 3 with blepharospasm, 13 with neck dystonia, 6 with writer's cramp, I with musician's cramp, and I with jaw dystonia. All patients with hemifacial spasm and blepharospasm obtained good results, while 77% of those with cervical dystonia received substantial benefit. Only half of those with writer's cramp improved. Hemifacial spasm seems more prevalent in Singapore compared with Western populations. CONCLUSION: Injections of botulinum toxin are useful in treating the various neurological disorders studied. This is an advancement in the treatment of these dyskinesias which respond poorly to oral medications.     

Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia

Goodpasture syndrome is an often fatal autoimmune disease associated with glomerulonephritis and/or pulmonary hemorrhage. The clinical manifestations of this disease correlate well with the presence of circulating antiglomerular basement membrane (GBM) autoantibodies. The primary target antigen in glomerular and alveolar basement membranes is thought to be the alpha 3 chain of type IV collagen. Nearly all that is known about anti-GBM antibodies in humans comes from work on unbound circulating antibody. We recently had the unique and rare opportunity to obtain early postmortem antibody and tissues from a patient who died with catastrophic Goodpasture syndrome. The specificity of circulating, kidney-bound and lung-bound autoantibodies from this patient was evaluated against a variety of purified basement membrane constituents. The results indicate that the primary target for the circulating and tissue-bound autoantibodies is the NC1 domain of the alpha 3(IV) chain of type IV collagen. Additionally, all the antibodies recognize a cryptic epitope/s on the alpha 3(IV)NC1 hexamer. Furthermore, tissue-bound and circulating antibodies compete with one another for overlapping epitopes on the antigen. These findings demonstrate that circulating autoantibodies in Goodpasture syndrome are highly representative of those bound to organ tissues, strengthening the notion that pathogenic autoantibodies are targeted to the alpha 3(IV)NC1 collagen, and that previous reports of findings in the circulation may be applicable to tissue injury.