Carbon nanotubes play an important role in the spatial arrangement of calcium deposits in hydrogels for bone regeneration

Age related bone diseases such as osteoporosis are considered among the main causes of reduced bone mechanical stability and bone fractures. In order to restore both biological and mechanical function of diseased/fractured bones, novel bioactive scaffolds that mimic the bone structure are constantly under development in tissue engineering applications. Among the possible candidates, chitosan-based thermosensitive hydrogel scaffolds represent ideal systems due to their biocompatibility, biodegradability, enhanced antibacterial properties, promotion of osteoblast formation and ease of injection, which makes them suitable for less invasive surgical procedures. As a main drawback, these chitosan systems present poor mechanical performance that could not support load-bearing applications. In order to produce more mechanically-competent biomaterials, the combined addition of hydroxyapatite and carbon nanotubes (CNTs) is proposed in this study. Specifically, the aim of this work is to develop thermosensitive chitosan hydrogels containing stabilised single-walled and multi-walled CNTs, where their effect on the mechanical/physiochemical properties, calcium deposition patterns and ability to provide a platform for the controlled release of protein drugs was investigated. It was found that the addition of CNTs had a significant effect on the sol–gel transition time and significantly increased the resistance to compression for the hydrogels. Moreover, in vitro calcification studies revealed that CNTs played a major role in the spatial arrangements of newly formed calcium deposits in the composite materials studied, suggesting that they may have a role in the way the repair of fragile and/or fractured bones occurs in vivo.     

Compositional and spin–orbit control on the electronic structure and optical characteristics of ZnHgTe alloys using mBJ–GGA approach

Employing systematic first-principle calculations to the family of tellurium II–VI compounds such as Hg- and Zn-based semiconductors and their related Zn_1?x Hg _x Te ternary alloys, we have simulated the electronic and optical characteristics incorporating the spin–orbit coupling effect. The salient features such as the band gaps and the optical spectra with a satisfactory adequate approach are computed with the so-called modified Becke–Johnson exchange correlation potential as implemented in the full-potential linearized augmented plane-wave scheme. The theoretical finding surmises that a topological insulating state may be caused with 25% of Zn concentration incorporated in HgTe material. Intriguingly, a band gap is conclusively developed near 0.25 eV in Zn_0.25Hg_0.75Te alloy. The relevant components like the band structure, optical response functions such as the real and imaginary parts of dielectric function, spectral dependence of optical conductivity, reflectivity spectrum, refractive index, electron energy loss function, and absorption coefficient are established for the bulk Zn_1?x Hg _x Te ternary alloys, while Zn composition spans in the range 0–1. The overall accordance between our results and other theoretical reports as well as experimental realization is fairly good. We infer that the current work may be beneficial for optical emitters/converters in solar cell devices applications.     

Pivotal Role of Phytohormones and Their Responsive Genes in Plant Growth and Their Signaling and Transduction Pathway under Salt Stress in Cotton

The presence of phyto-hormones in plants at relatively low concentrations plays an indispensable role in regulating crop growth and yield. Salt stress is one of the major abiotic stresses limiting cotton production. It has been reported that exogenous phyto-hormones are involved in various plant defense systems against salt stress. Recently, different studies revealed the pivotal performance of hormones in regulating cotton growth and yield. However, a comprehensive understanding of these exogenous hormones, which regulate cotton growth and yield under salt stress, is lacking. In this review, we focused on new advances in elucidating the roles of exogenous hormones (gibberellin (GA) and salicylic acid (SA)) and their signaling and transduction pathways and the cross-talk between GA and SA in regulating crop growth and development under salt stress. In this review, we not only focused on the role of phyto-hormones but also identified the roles of GA and SA responsive genes to salt stress. Our aim is to provide a comprehensive review of the performance of GA and SA and their responsive genes under salt stress, assisting in the further elucidation of the mechanism that plant hormones use to regulate growth and yield under salt stress.     

Mammogram Enhancement Using Lifting Dyadic Wavelet Transform and Normalized Tsallis Entropy

In this paper, we present a new technique for mammogram enhancement using fast dyadic wavelet transform （FDyWT） based on lifted spline dyadic wavelets and normalized Tsallis entropy. First, a mammogram image is decom- posed into a multiscale hierarchy of low-subband and high-subband images using FDyWT. Then noise is suppressed using normalized Tsallis entropy of the local variance of the modulus of oriented high-subband images. After that, the wavelet coefficients of high-subbands are modified using a non-linear operator and finally the low-subband image at the first scale is modified with power law transformation to suppress background. Though FDyWT is shift-invariant and has better poten- tial for detecting singularities like edges, its performance depends on the choice of dyadic wavclcts. On the other hand, the nulnber of vanishing moments is an important characteristic of dyadic wavelets for singularity analysis because it provides an upper bound measurement for singularity characterization. Using lifting dyadic schemes, we construct lifted spline dyadic wavelets of different degrees with increased number of vanishing moments. We also examine the effect of these wavelets on mammogram enhancement. The method is tested on mammogram images, taken from MIAS （Mammographic Image Analysis Society） database, having various background tissue types and containing different abnormalities. The comparison with tile state-of-the-art contrast enhancement methods reveals that the proposed method performs better and the difference is statistically significant.     

Toward the modeling of data provenance in scientific publications

In this paper, we implement a provenance-aware system for documenting publications, called PADS. It employs a three-layered provenance hierarchy, which can output diverse types of provenance data related to the research life cycle. From this, we generate different profiles for research ventures, reviewers, and authors. PADS employs the standard Open Provenance Model (OPM) specification for capturing provenance data, and stores this data as ontological instances. We show that data is retrieved without any apparent delay in the execution time of the queries. We also demonstrate how this data can be used to make useful recommendations to the organizers, in order to manage upcoming research ventures.     

Control of a robotic orthosis for gait rehabilitation

Robot assisted gait training may help in producing rapid improvements in functional gait parameters. This paper presents new experimental results with an intrinsically compliant robotic gait training orthosis. The newly developed robotic orthosis has 6 degrees of freedom (DOFs). A trajectory tracking controller based on the boundary layer augmented sliding control (BASMC) law was implemented to guide the subject’s limbs on physiological gait trajectories. The compliance of the robotic orthosis sagittal plane hip and knee joints was also controlled, independently of the trajectory tracking control. The robotic orthosis and the control scheme were evaluated on three neurologically intact subjects walking on a treadmill. A maximum trajectory tracking error of 10° was recorded at the hip and knee sagittal plane joints. The results showed that subjects can walk in the robotic orthosis with comfort and the BASMC law was able to guide the subject’s limbs on reference physiological trajectories.     

A group theoretic approach to construct cryptographically strong substitution boxes

In this paper, we present a method to construct a substitution box used in encryption applications. The proposed algorithm for the construction of substitution box relies on the linear fractional transform method. The design methodology is simple, while the confusion-creating ability of the new substitution box is complex. The strength of the proposed substitution box is evaluated, and an insight is provided to quantify the confusion-creating ability. In addition, tests are performed to assess the vulnerability of the encrypted data to algebraic and statistical attacks. The substitution box is critically analyzed by strict avalanche criterion, bit independent criterion, differential approximation probability test, linear approximation probability test, non-linearity test, and majority logic criterion. The performance of the proposed substitution box is also compared with those of some of the well-known counterparts including AES, APA, Gray, S₈, Skipjack, Xyi, and prime of residue substitution boxes. It is apparent that the performance, in terms of confusion-creating ability, of the new substitution box is better than those of some of the existing non-linear components used in encryption systems. The majority logic criterion is applied to these substitution boxes to further evaluate the strength and usefulness.     

Coherent control of symmetric and asymmetric diffraction grating via relative phase

ABSTRACT

We present a theoretical model to realize the symmetric and asymmetric diffraction grating in a four-level atomic medium. The proposed atomic medium follows a double lambda configuration where four fields interact with it. We get control over symmetric and asymmetric behavior of the diffraction grating by manipulating the relative phase of the fields. Interestingly, the symmetric and asymmetric diffraction grating become prominent when the vortex beam is used instead of the plane wave. Enhanced first, second, and third-order diffraction gratings are achieved via the vortex beam. Further, we find control over asymmetric diffraction gratings by the relative phase of the fields. Coherent control of asymmetric diffraction grating in negative and positive diffracted angles is also achieved via the relative phase.     

Study on crosslinked gelatin–montmorillonite nanoparticles for controlled drug delivery applications

Gelatin, because of its biodegradability and ecofriendly nature, has been the best choice for controlled release applications. Montmorillonite (MMT) clay shows a very important role in controlling drug delivery. Hence, an attempt was made in this work to prepare gelatin–MMT nanoparticles by desolvation method using acetone as precipitating agent, glutaraldehyde (GA) as crosslinking agent, and water as reaction media for controlled delivery of isoniazid, a drug for tuberculosis. Characterization of the MMT and isoniazid-loaded gelatin–MMT nanoparticles was carried out using Fourier transform infrared spectroscopy, X-ray diffraction study, scanning electron microscopy study, and transmission electron microscopy study. The effect of MMT on gelatin nanoparticles was evaluated in terms of water uptake studies, and subsequently to the release of isoniazid drug in buffer solution at pH 1.2 (gastric pH) and pH 7.4 (intestinal pH). Swelling experiment indicated that the gelatin nanoparticles were very sensitive to the pH environment. The release profile of drug was studied by a UV–Visible spectrophotometer. Cytotoxicity study revealed that MMT-containing nanoparticles showed less cytotoxicity than MMT-free nanoparticles.