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51.
Alexandra E. Butler Abu Saleh Md Moin Thozhukat Sathyapalan Stephen L. Atkin 《International journal of molecular sciences》2022,23(20)
Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitory proteins. In this cohort study, plasma was collected from 234 women (137 with PCOS and 97 controls). SOMALogic proteomic analysis was undertaken for the following complement system proteins: C1q, C1r, C2, C3, C3a, iC3b, C3b, C3d, C3adesArg, C4, C4a, C4b, C5, C5a, C5b-6 complex, C8, properdin, factor B, factor D, factor H, factor I, mannose-binding protein C (MBL), complement decay-accelerating factor (DAF) and complement factor H-related protein 5 (CFHR5). The alternative pathway of the complement system was primarily overexpressed in PCOS, with increased C3 (p < 0.05), properdin and factor B (p < 0.01). In addition, inhibition of this pathway was also seen in PCOS, with an increase in CFHR5, factor H and factor I (p < 0.01). Downstream complement factors iC3b and C3d, associated with an enhanced B cell response, and C5a, associated with an inflammatory cytokine release, were increased (p < 0.01). Hyperandrogenemia correlated positively with properdin and iC3b, whilst insulin resistance (HOMA-IR) correlated with iC3b and factor H (p < 0.05) in PCOS. BMI correlated positively with C3d, factor B, factor D, factor I, CFHR5 and C5a (p < 0.05). This comprehensive evaluation of the complement system in PCOS revealed the upregulation of components of the complement system, which appears to be offset by the concurrent upregulation of its inhibitors, with these changes accounted for in part by BMI, hyperandrogenemia and insulin resistance. 相似文献
52.
Polypropylene (PP) hybrid composites have been produced by compounding two types of mineral fillers, viz., talc and kaolin with PP copolymer using a twin screw extruder. The PP hybrid composite was injection‐molded into dumbbell specimen for tensile, flexural, and impact properties characterizations. MFI and SEM studies were used to characterize the flow and morphological properties of the PP hybrid composites. The result shows that most of the hybrid composites showed a significant decrease in flow, tensile, flexural, and impact properties compared with the single filler‐filled PP composites. However, a hybridization effect was seen for the PPT20K10 hybrid composites, through the synergistic coalescence of positive characteristics from 20 wt % of talc and 10 wt % of kaolin. This hybrid formulation have given an economically advantageous material with the mechanical properties (tensile, flexural, and impact) comparable to those of the talc‐filled PP composites. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 434–441, 2007 相似文献
53.
Proteome Based Approach Defines Candidates for Designing a Multitope Vaccine against the Nipah Virus
Mohamed A. Soltan Muhammad Alaa Eldeen Nada Elbassiouny Ibrahim Mohamed Dalia A. El-damasy Eman Fayad Ola A. Abu Ali Nermin Raafat Refaat A. Eid Ahmed A. Al-Karmalawy 《International journal of molecular sciences》2021,22(17)
Nipah virus is one of the most harmful emerging viruses with deadly effects on both humans and animals. Because of the severe outbreaks, in 2018, the World Health Organization focused on the urgent need for the development of effective solutions against the virus. However, up to date, there is no effective vaccine against the Nipah virus in the market. In the current study, the complete proteome of the Nipah virus (nine proteins) was analyzed for the antigenicity score and the virulence role of each protein, where we came up with fusion glycoprotein (F), glycoprotein (G), protein (V), and protein (W) as the candidates for epitope prediction. Following that, the multitope vaccine was designed based on top-ranking CTL, HTL, and BCL epitopes from the selected proteins. We used suitable linkers, adjuvant, and PADRE peptides to finalize the constructed vaccine, which was analyzed for its physicochemical features, antigenicity, toxicity, allergenicity, and solubility. The designed vaccine passed these assessments through computational analysis and, as a final step, we ran a docking analysis between the designed vaccine and TLR-3 and validated the docked complex through molecular dynamics simulation, which estimated a strong binding and supported the nomination of the designed vaccine as a putative solution for Nipah virus. Here, we describe the computational approach for design and analysis of this vaccine. 相似文献
54.
55.
Blends of wheat flour (WF) and African yam bean water-extractable proteins (AYBWEP) were processed into bread and cookies in the following ratios: 100: 0; 95: 5; 90: 10; 85: 15; 80: 20. The proximate composition, physical, chemical properties and sensory properties of bread and cookies samples from the blends were determined. Breads and cookies produced from the resultant blends were significantly higher (p < 0.05) in protein (16.39% – 18.36%) than the control (11.80% – 12.58%). Carbohydrate content decreased from 60.74% with addition of AYBWEP to 52.81% following 20% substitution. The pH of bread samples prepared from whole wheat flour and blends of wheat flour and AYBWEP were significantly different (p < 0.05) while bulk density and specific volume were not significantly different (p > 0.05). The pH of bread samples and cookies decreased with increase in the proportion of the AYBWEP blend from 5% to 20%. The highest specific volume (3.70 ml/g) was observed in bread samples prepared from the control 100: 0 blends while the 80:20 blends had the lowest specific volume (3.10 ml/g). There was no significant difference (p > 0.05) in the bulk density and thickness of the cookies. The cookies prepared using 80: 20 blends had the higher diameter (22.53 cm) and spread factor (54.03 cm) compared to the control. Generally, acceptability of the bread and cookies decreased with higher ratios of AYBWEP inclusion. The sensory acceptability scores showed the best AYBWEP substitution level for making bread and cookies was 5% and 10% of the AYBWEP respectively. The results are discussed in the context of the growing importance of promoting the processing and utilization of lesser known local crops in baked products.enrichment. 相似文献
56.
M. B. Abu Bakar Z. A. Mohd Ishak R. Mat Taib H. D. Rozman S. Mohamad Jani 《应用聚合物科学杂志》2010,116(5):2714-2722
Polypropylene (PP) composites filled with wood flour (WF) were prepared with a twin‐screw extruder and an injection‐molding machine. Three types of ecologically friendly flame retardants (FRs) based on ammonium polyphosphate were used to improve the FR properties of the composites. The flame retardancy of the PP/WF composites was characterized with thermogravimetric analysis (TGA), vertical burn testing (UL94‐V), and limiting oxygen index (LOI) measurements. The TGA data showed that all three types of FRs could enhance the thermal stability of the PP/WF/FR systems at high temperatures and effectively increase the char residue formation. The FRs could effectively reduce the flammability of the PP/WF/FR composites by achieving V‐0 UL94‐V classification. The increased LOI also showed that the flammability of the PP/WF/FR composites was reduced with the addition of FRs. The mechanical property study revealed that, with the incorporation of FRs, the tensile strength and flexural strength were decreased, but the tensile and flexural moduli were increased in all cases. The presence of maleic anhydride grafted polypropylene (MAPP) resulted in an improvement of the filler–matrix bonding between the WF/intumescent FR and PP, and this consequently enhanced the overall mechanical properties of the composites. Morphological studies carried out with scanning electron microscopy revealed clear evidence that the adhesion at the interfacial region was enhanced with the addition of MAPP to the PP/WF/FR composites. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 相似文献
57.
Wan Azelee Wan Abu Bakar Mohd Yusuf Othman Rusmidah Ali Ching Kuan Yong 《Catalysis Letters》2009,128(1-2):127-136
Supported nickel oxide based catalysts were prepared by wetness impregnation method for the in-situ reactions of H2S desulfurization and CO2 methanation from ambient temperature up to 300 °C. Fe/Co/Ni (10:30:60)–Al2O3 and Pr/Co/Ni (5:35:60)–Al2O3 catalysts were revealed as the most potential catalysts, which yielded 2.9% and 6.1% of CH4 at reaction temperature of 300 °C, respectively. From XPS, Ni2O3 and Fe3O4 were suggested as the surface active components on the Fe/Co/Ni (10:30:60)–Al2O3 catalyst, while Ni2O3 and Co3O4 on the Pr/Co/Ni (5:35:60)–Al2O3 catalyst. 相似文献
58.
M. Abdul Mujeebu M.Z. Abdullah M.Z. Abu Bakar A.A. Mohamad M.K. Abdullah 《Progress in Energy and Combustion Science》2009
Utilization of a porous medium for combustion of liquid fuels is proved to be a promising approach for future applications. The porous medium burner for liquid fuels is more advantageous than the conventional open spray flame burner for several reasons; these include enhanced evaporation of droplet spray owing to regenerative combustion characteristics, low emission of pollutants, high combustion intensity with moderate turn-down ratio and compactness. This article provides a comprehensive picture of the global scenario of research and developments in combustion of liquid fuels within a porous medium that enable a researcher to determine the direction of further investigation. Accordingly, a glossary of the important terminology, the modeling approach, advances in numerical and experimental works and applications are included. The papers published in standard journals are reviewed and summarized with relevant comments and suggestions for future work. 相似文献
59.
There are increasing demands on portable communication devices to run multimedia applications. ISO (an International Organization
for Standardization) standard MPEG-4 is an important and demanding multimedia application. To satisfy the growing consumer
demands, more functions are added to support MPEG-4 video applications. With improved CPU speed, memory sub-system deficiency
is the major barrier to improving the system performance. Studies show that there is sufficient reuse of values for caching
that significantly reduce the memory bandwidth requirement for video data. Software decoding of MPEG-4 video data generates
much more cache-memory traffic than required. Proper understanding of the decoding algorithm and the composition of its data
set is obvious to improve the performance of such a system. The focus of this paper is cache modeling and optimization for
portable communication devices running MPEG-4 video decoding algorithm. The architecture we simulate includes a digital signal
processor (DSP) for running the MPEG-4 decoding algorithm and a memory system with two levels of caches. We use VisualSim
and Cachegrind simulation tools to optimize cache sizes, levels of associativity, and cache levels for a portable device decoding
MPEG-4 video.
Abu Asaduzzaman is, currently, a PhD candidate in the department of Computer Science and Engineering (CSE), Florida Atlantic University (FAU),
Boca Raton, Florida. He received his MS degree in computer engineering from FAU in 1997.
Mr. Asaduzzaman worked for ECI Telecom as a software engineer from 1998 to 2001. From 2001 to 2003, he worked for BlueCross
and BlueShield of Florida and SunPass (FDoT) as an IT Consultant. Currently, he is working as a research assistant at CSE
Dept, FAU. His research interests include cache optimization, architecture exploration, embedded system evaluation, and networks-on-a-chip
(NoC). He has published several research papers in these areas. Abu is a member of the honor society of Phi Kappa Phi, Tau
Beta Pi, Upsilon Phi Epsilon, and the Association for Computing Machinery (ACM) FAU Chapter.
Imad Mahgoub received the MS degree in applied mathematics and MS degree in electrical and computer engineering, both from North Carolina
State University, Raleigh in 1983 and 1986 respectively and the PhD degree in computer engineering from the Pennsylvania State
University, University Park, PA in 1989.
Dr. Mahgoub joined Florida Atlantic University (FAU), Boca Raton, Florida in 1989. Currently he is a full professor of Computer
Science and Engineering department and the director of the Mobile Computing Laboratory. His research interests include performance
evaluation, mobile computing, sensor networks, and parallel and distributed processing. He has published over 80 research
papers in these areas. He is the co-editor of the Mobile Computing Handbook and the Handbook of Sensor Networks. Dr. Mahgoub
has served on the program committees of numerous conferences. He has been the vice-chair for the Symposium on Performance
Evaluation of Computer and Telecommunication Systems (SPECTS) since 2003. He is a senior member of the IEEE. He is also a
member of Tau Beta Pi, Upsilon Pi Epsilon, the IEEE Computer Society, and the ACM. 相似文献
60.
Intermittent aeration of cutting oil emulsion was shown to reduce but not eliminate sulphate reducing bacteria (srb). Removing iron swarf from infected cutting fluid markedly reduced the numbers of srb detected in the fluid, and prevented the characteristic grey spoilage which these organisms promote. It was shown that large numbers of srb are in fact adherent to the metal surfaces. 相似文献