Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine

The elastic properties of carotid arteries of spontaneously hypertensive rats (SHR) and normotensive controls (Wistar-Kyoto rats [WKY]) were examined in vivo, in situ, and in vitro. The changes of internal diameter were measured with a high-resolution A-mode echo-tracking device simultaneously with the intra-arterial pressure at the carotid. The internal diameter at mean arterial blood pressure (MBP) was substantially smaller in vitro than in vivo in SHR (-33.8%) and WKY (-48.3%). The arterial distensibility was lower in vitro in all arteries compared with in vivo conditions (SHR, -30.1%; WKY, -60.4%; at MBP) despite a reduced incremental elastic modulus in vitro (SHR, -56.9%; WKY, -45.1%; at MBP). However, the in vitro and in vivo measurements show consistent elastic behavior of the carotid arteries between both strains of rats. Carotid arteries from WKY were also examined in situ. Although no significant reduction in internal diameter could be observed in situ, distensibility was dramatically decreased (-87% at MBP). These results emphasize the importance of considering the original vascular geometry when determining elastic properties of arteries. We conclude that experimental conditions are likely to be a critical determinant for the assessment of the mechanical properties of conduit vessels.     

Intellectual deficits after transient tyrosinemia in the term neonate

An analysis was made of the obstetric history of 1,360 patients who were delivered in 1971. It involved 3,185 pregnancies. The aim of the study was to evaluate the risk of spontaneous termination of the pregnancy, worked out from its demographic aspect. Several ideas are worthy of consideration. The risk of spontaneous intra-uterine death is cumulative, sharply increased by a repetition of such cessation of pregnancy. The same patients often undergo intentional abortion repeatedly. The respective risks of spontaneous and provoked interruption of pregnancy have been studied in greater detail as a function of parity.     

Intrinsic reactivity of carbons to oxygen

The analysis of carbon oxidation data presented in a previous Fuel paper is shown to contain an error, as a result of which the intrinsic reactivity of carbon to oxygen is under-estimated by a factor of between one and four.     

Flavonol glycosides and flavonol glucoside gallates from Peltophorum africanum

In this study of interactions occurring within the heart, isolated superfused strips of rabbit atria, containing the sinoatrial (s.a.) node, were subjected to sinusoidal subthreshold current pulses of varied frequencies and intensities. A.C. current from an R.C. oscillator was applied through a Grass stimulation isolation unit, push-pull connection, and non-polarizing (Ag-AgCl-KCl-Tyrode Agar-Agar) electrodes. A Grass polygraph and tachometer were used to record the applied pulses and nodal firing rates; simultaneous magnetic tape recordings were obtained and used for data analysis. Suction electrode recordings and oscilloscope displays were used to determine how the cyclic impulses affected cellular activity. The s.a. nodal rhythm was modified by subthreshold A.C. current applications; when frequencies were low, firing rates of the node were modulated by the A.C. and mean rates were reduced. As frequencies were progressively increased, slow waxings and wanings in heart rate were produced. These periodic fluctuations were not readily correlated with either the A.C. frequency nor the intrinsic nodal rate, but were representative of the difference between the two. As applied current frequency neared the pacemaker's intrinsic rate, a synchronization occurred and the discharges locked in at a specific phase of the applied current alternation. This synchronization maintained during slight further increases in A.C. frequency but above a critical rate this relationship broke down and the waxing and wanings in frequency of pacemaker rate again developed. It was concluded that pacemaker action of the s.a. node is effected by integration of cellular activity through electron coupling.     

Power Law Velocity Profile in Fully Developed Turbulent Pipe and Channel Flows

The power law velocity profile has been analyzed in terms of the envelope of the friction factor which gives the friction factor log law. The power law index α and prefactor C are shown as the function of the friction Reynolds number, as well as the function of the alternate variable the nondimensional friction velocity. The fully developed turbulent superpipe flow data of McKeon et al. and fully developed channel flow data of Zanoun et al. have been analyzed and the power law index α and prefactor C data have been estimated, first as a function of the friction Reynolds number and second as function of the nondimensional friction velocity. Based on analysis, several correlations have been proposed that have been supported by the data.     

An Empirical Study of Factors Affecting e-Commerce Adoption among Small- and Medium-Sized Enterprises in a Developing Country: Evidence from Malaysia

The purpose of this paper is to empirically examine determinants of e-commerce adoption among Malaysian small- and medium-sized enterprises (SMEs). This study tested eight hypotheses on determinants affecting e-commerce adoption with empirical data from several survey instruments: an online questionnaire-based survey, mailed survey and questionnaire collected in-person from a sample of 307 SMEs in Malaysia. The findings show that e-commerce adoption within Malaysian SMEs is affected by perceived relative advantage, perceived compatibility, managers/owner's knowledge and expertise, management characteristics and external change agents. This study contributes to enhancing the understanding of the determinants of adopting e-commerce in SMEs and provides some interesting perspective from Malaysia. Those parties interested in promoting their business online may find these results helpful in guiding their efforts.     

A novel folded-torus based network architecture for power-aware multicore systems

Multicore computers are expected to be used to process a higher volume of data in the future. Current mesh-like multicore architecture is inadequate to increase memory-level-parallelism because of its poor core-to-core interconnection topology. In some architecture, each node has communication and computation components – switching component of such a node consumes power while the node is only computing and vice versa. In this paper, we propose a folded-torus based topology to improve performance and energy saving. In this architecture, nodes are separated between network switches and computing cores. Using folded-torus concept, we develop a scheme to connect the components (switches and cores) of a multicore architecture. Experimental results show that the proposed architecture outperforms Raw Architecture Workstation (RAW), Triplet Based Architecture (TriBA), and Logic-Based Distributed Routing (LBDR) architecture by reducing the switches more than 53%, the power consumption by up to 71%, and the average delay by up to 58%.     

Evaluation of simple dynamic models and controllers for hydraulic and nozzle pressure in injection molding

Simple pseudo-steady state relations between the hydraulic and nozzle pressures of an injection molding machine were presented and verified experimentally. A simulation study was performed to evaluate the performance of simple controllers using dynamic models developed for the hydraulic and nozzle pressures. The controllers chosen were the discrete proportional, proportional-integral (PI), and proportional-integral-derivative (PID) types, tuned according to the ITAE criterion. The control of hydraulic pressure simulation showed that the PI controller had the best overall performance, whereas the result of nozzle pressure control loop simulation showed that the PID controller performance was better than that of the PI controller. All the controllers, in both loops, gave responses that were about an order of magnitude more rapid than the open loop response.