European lead fast reactor—ELSY

The conceptual design of the European Lead Fast Reactor is being developed starting from September 2006, in the frame of the EU-FP6-ELSY project. The ELSY (European Lead-cooled System) reference design is a 600 MWe pool-type reactor cooled by pure lead. The ELSY project demonstrates the possibility of designing a competitive and safe fast critical reactor using simple engineered technical features, while fully complying with the Generation IV goal of sustainability and minor actinide (MA) burning capability. Sustainability was a leading criterion for option selection for core design, focusing on the demonstration of the potential to be self sustaining in plutonium and to burn its own generated MAs. To this end, different core configurations have been studied. Economics was a leading criterion for primary system design and plant layout. The use of a compact and simple primary circuit with the additional objective that all internal components be removable, are among the reactor features intended to assure competitive electric energy generation and long-term investment protection. Low capital cost and construction time are pursued through simplicity and compactness of the reactor building (reduced footprint and height). The reduced plant footprint is one of the benefits coming from the elimination of the Intermediate Cooling System, the low reactor building height is the result of the design approach which foresees the adoption of short-height components and two innovative Decay Heat Removal (DHR) systems. Among the critical issues, the impact of the large mass of lead has been carefully analyzed; it has been demonstrated that the high density of lead can be mitigated by compact solutions and adoption of seismic isolators. Safety has been one of the major focuses all over the ELSY development. In addition to the inherent safety advantages of lead coolant (high boiling point and no exothermic reactions with air or water) a high safety grade of the overall system has been reached. In fact the overall primary system has been conceived in order to minimize pressure drops and, as a consequence, to allow decay heat removal by natural circulation. Moreover two redundant, diverse and passive operated DHR systems have been developed and adopted. The paper presents the overall work performed so far.     

New evidence on measuring the geographical concentration of economic activities

Spatial interactions among regional units may influence the geographical distribution of economic activities. Many traditional measures of geographical concentration fail in capturing this aspect, being insensitive to permutations of the spatial position of regions. This paper proposes an approach to the measurement of geographical concentration of economic activities that accounts for spatial interactions among regions. The locational Gini is split into spatial and non-spatial components, so that a new interpretation of the index is presented. The measure is applied to evaluate the geographical concentration of different economic sectors for 1,323 NUTS 3 regions in the European Union over the period 2001–2018.     

Antimicrobial Activity of Isothiocyanates from Cruciferous Plants against Methicillin-Resistant Staphylococcus aureus (MRSA)

Purified isothiocyanates from cruciferous plants (Brassicacea, Syn. Cruciferae) plants were evaluated against 15 isolates of methicillin-resistant S. aureus isolated from diabetic foot-ulcer patients aiming the study of the potential usage of allyl-isothiocyanate, benzyl-isothiocyanate and 2-phenylethyl-isothiocyanate against this important bacteria. Disc diffusion and minimum inhibitory concentration methods were used to access the antimicrobial activity. The index (Ia) and rate (Ra) of the antibacterial activity for each compound were calculated. The results showed a highly dose-dependent compound and chemical structure antibacterial effectiveness. The results showed a strong relation between the chemical structure of isothiocyanates and its antibacterial effectiveness. The benzyl-isothiocyanate was the most effective with a minimum inhibitory concentration varying between 2.9 and 110 µg· mL⁻¹ with an antibacterial activity rate up to 87%. Moreover, their antibacterial activity was mainly bactericidal. This study provides scientific evidence that isothiocyanates have an interesting biological value and must be considered as an important tool to be used against MRSA.     

Centinela: A human activity recognition system based on acceleration and vital sign data

This paper presents Centinela, a system that combines acceleration data with vital signs to achieve highly accurate activity recognition. Centinela recognizes five activities: walking, running, sitting, ascending, and descending. The system includes a portable and unobtrusive real-time data collection platform, which only requires a single sensing device and a mobile phone. To extract features, both statistical and structural detectors are applied, and two new features are proposed to discriminate among activities during periods of vital sign stabilization. After evaluating eight different classifiers and three different time window sizes, our results show that Centinela achieves up to 95.7% overall accuracy, which is higher than current approaches under similar conditions. Our results also indicate that vital signs are useful to discriminate between certain activities. Indeed, Centinela achieves 100% accuracy for activities such as running and sitting, and slightly improves the classification accuracy for ascending compared to the cases that utilize acceleration data only.     

Molecular Dynamics at Extended Timescales

The use of short time trajectory fragments to enhance sampling of kinetics is discussed. It is argued that partitioning of phase space with interfaces that are called milestones and conducting a large number of short time trajectories between these interfaces is a highly efficient and accurate method to calculate thermodynamics and kinetics. The method of Milestoning, which is a theory and an algorithm, enables the rapid calculations of fluxes, stationary distributions, and moments of the mean first passage time. It is based on sub-nanosecond trajectories between cell partitions (milestones) that are defined in coarse space. While the method was applied in the past to highly complex systems, we illustrate it here on a pedagogical two-dimensional system using dividers of Voronoi cells as milestones.