全文获取类型
收费全文 | 103篇 |
免费 | 11篇 |
专业分类
化学工业 | 40篇 |
机械仪表 | 1篇 |
建筑科学 | 3篇 |
轻工业 | 19篇 |
无线电 | 5篇 |
一般工业技术 | 22篇 |
冶金工业 | 14篇 |
自动化技术 | 10篇 |
出版年
2023年 | 3篇 |
2022年 | 11篇 |
2021年 | 11篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 4篇 |
2013年 | 2篇 |
2012年 | 3篇 |
2011年 | 9篇 |
2010年 | 11篇 |
2009年 | 3篇 |
2008年 | 5篇 |
2007年 | 4篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1987年 | 1篇 |
排序方式: 共有114条查询结果,搜索用时 0 毫秒
111.
Spiroketals are key structural motifs found in diverse natural products with compelling biological activities. However, stereocontrolled synthetic access to spiroketals, independent of their inherent thermodynamic preferences, is a classical challenge in organic synthesis that has limited in-depth biological exploration of this intriguing class. Herein, we review our laboratory's efforts to advance the glycal epoxide approach to the stereocontrolled synthesis of spiroketals via kinetically controlled spirocyclization reactions. This work has provided new synthetic methodologies with applications in both diversity- and target-oriented synthesis, fundamental insights into structure and reactivity, and efficient access to spiroketal libraries and natural products for biological evaluation. 相似文献
112.
113.
Alyssa Vito Stephanie Rathmann Natalie Mercanti Nader El-Sayes Karen Mossman John Valliant 《International journal of molecular sciences》2021,22(9)
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease with poor clinical outcomes and limited therapeutic options. Immune checkpoint blockade (CP) has surged to the forefront of cancer therapies with widespread clinical success in a variety of cancer types. However, the percentage of TNBC patients that benefit from CP as a monotherapy is low, and clinical trials have shown the need for combined therapeutic modalities. Specifically, there has been interest in combining CP therapy with radiation therapy where clinical studies primarily with external beam have suggested their therapeutic synergy, contributing to the development of anti-tumor immunity. Here, we have developed a therapeutic platform combining radionuclide therapy (RT) and immunotherapy utilizing a radiolabeled biomolecule and CP in an E0771 murine TNBC tumor model. Survival studies show that while neither monotherapy is able to improve therapeutic outcomes, the combination of RT + CP extended overall survival. Histologic analysis showed that RT + CP increased necrotic tissue within the tumor and decreased levels of F4/80+ macrophages. Flow cytometry analysis of the peripheral blood also showed that RT + CP suppressed macrophages and myeloid-derived suppressive cells, both of which actively contribute to immune escape and tumor relapse. 相似文献
114.
Lee Harold O. Vallejos Alyssa M. Rimsza Jessica M. Chin Clare Davis-Wheeler Ringgold Marissa Nicholas James R. Treadwell LaRico J. 《Journal of Materials Science》2022,57(11):6167-6181
Journal of Materials Science - Copper nanoparticles (Cu-NPs) have garnered attention due to their high electrical and thermal conductivity, high melting point, and relatively low cost compared to... 相似文献