Solidification at the Micro‐Scale

The experimental determination and computer simulation of the micro‐segregation accompanying the solidification of alloys continues to be a subject of much academic and industrial interest. Both are subject to progressively more sophisticated analyses, and a discussion is offered regarding the development and practical use of such studies. Simple steels are particularly difficult targets for such work: solidification does not end conveniently in a eutectic, the rapid diffusion particularly in the delta‐ferrite phase obscures most evidence of what had occurred at the micro‐scale during solidification, and one or more subsequent solid state phase transformations further obscure such details. Also, solidification at the micro‐scale is inherently variable: the usual, dendrite morphologies encountered are, after all, instabilities in growth behaviour, and therefore such variability should be expected. For questions such as the relative susceptibility of different grades to particular problems, it is the average, typical behaviour that is of interest, whereas for other questions such as the on‐set of macro‐segregation, the local variability is paramount. Depending on the question being asked, and indeed the accuracy with which validatory data are available, simple pseudo‐analytical equations employing various limiting assumptions, or sophisticated models which remove the need for most such limitations, could be appropriate. This paper highlights the contribution to such studies of various collaborative research forums with‐in the European Union with which the author is involved.     

Monolithically integrated SQW laser and HBT laser driver viaselective OMVPE regrowth

An AlGaAs/GaAs nan heterojunction bipolar transistor (HBT) laser driver circuit and a pseudomorphic InGaAs/GaAs/AlGaAs graded index single-quantum-well (SQW) laser have been laterally integrated to maintain surface planarity using selective organometallic vapor-phase epitaxy (OMVPE) regrowth of the HBT. The self-aligned HBTs exhibit a DC current gain of 30 and an f_t (f_max ) of 45(60) GHz. The 980-nm lasers exhibit room-temperature threshold current densities as low as 420(320) A/cm² for CW (pulsed) operation. The cavities are 40(7) μm×500 μm and have less than 1(2) Ω of series resistance. SPICE simulations of the integrated driver indicate that operating speeds of over 10 Gb/s are possible     

State psychological association creates a postdoctoral residency and internship training program.

State psychological associations can respond to supply and demand problems for postdoctoral residencies and internships by creating statewide training programs. A state psychological association training model is presented. The Arizona Psychological Association (AzPA) created a nonprofit subsidiary corporation- the Arizona Psychology Training Consortium-to increase the number of high-quality training opportunities in Arizona. The structure and operation of the program are described. The training model emphasizes cultural diversity, psychotherapy, and independent practice. Members of the practice community in Arizona serve as supervisors, trainers, and mentors. From 2001 through 2006, 19 postdoctoral residents and 51 interns completed the program. AzPA has benefited from increased student involvement. Many residents and interns later became association members. Arizona can serve as a model for other states that wish to help their professionals in training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Conformal proton therapy for prostate carcinoma

The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both in vivo and in vitro. Here, we extend these observations by demonstrating the ability of nafenopin to suppress apoptosis induced by other major candidates for the signalling of cell death in the liver. Treatment of rat or mouse hepatocyte monolayers with TGFbeta1 or the DNA damaging drugs etoposide or hydroxyurea induced high levels of apoptosis. Western blot analysis did not support a role for either p53 or p21waf1 in etoposide-induced apoptosis in rat hepatocytes. Treatment of mouse hepatocytes with an agonistic anti-Fas antibody also resulted in an induction of high levels of apoptosis. Pre-addition and continued exposure to nafenopin suppressed apoptosis induced by all three stimuli. Overall, our studies demonstrate that the ability of nafenopin to protect hepatocytes from apoptosis is not restricted to species or apoptotic stimulus. It is possible, therefore, that the PPs may suppress apoptosis by acting on diverse signalling pathways. However, it seems more likely that nafenopin suppresses hepatocyte apoptosis elicited by each death stimulus by impinging on a core apoptotic mechanism.     

Increasing breast and cervical cancer screening in low-income women

Active cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) was treated with an intraocular sustained-release ganciclovir implant. A total number of 19 implants were performed in 15 eyes of 9 AIDS patients. The intraocular sustained-release ganciclovir was effective in preventing reactivation of CMV retinitis in 15 of the 19 implants, ineffective in 3, and undetermined in 1. All ineffective cases had been resistant to ganciclovir therapy before the implants. Vision after the therapy was maintained at better than 0.5 except for one eye. There were no serious ocular complications caused by the therapy. Among 5 patients with unilateral CMV retinitis, 2 unaffected eyes developed CMV retinitis during this therapy. In addition, another patient developed presumed CMV infection in other systemic organs. Based on these data, the intraocular sustained-release ganciclovir implant was considered to be useful for the treatment of CMV retinitis in AIDS.     

Types and associated type families for hardware simulation and synthesis

In this article we overview the design and implementation of the second generation of Kansas Lava. Driven by the needs and experiences of implementing telemetry decoders and other circuits, we have made a number of improvements to both the external API and the internal representations used. We have retained our dual shallow/deep representation of signals in general, but now have a number of externally visible abstractions for combinatorial and sequential circuits, and enabled signals. We introduce these abstractions, as well as our abstractions for reading and writing memory. Internally, we found the need to represent unknown values inside our circuits, so we made aggressive use of associated type families to lift our values to allow unknowns, in a principled and regular way. We discuss this design decision, how it unfortunately complicates the internals of Kansas Lava, and how we mitigate this complexity. Finally, when connecting Kansas Lava to the real world, the standardized idiom of using named input and output ports is provided by Kansas Lava using a new monad, called Fabric. We present the design of this Fabric monad, and illustrate its use in a small but complete example.     

Computer simulations of time-dependent suppression of EOF by polymer coatings

We use molecular dynamics simulations in order to investigate the time evolution of the effect of adsorbed polymer coatings on the electro-osmotic flow (EOF) in a capillary. Weakly adsorbed coatings show no time-dependent performance, but they do not strongly reduce the EOF. On the other hand, strongly adsorbed coatings made of longer polymer chains are often quenched in non-equilibrium conformations that can strongly reduce the EOF over extremely long periods of time. For intermediate adsorption strengths, we observe that the EOF increases as a function of time due to the relaxation of the coating layer. The concentration of polymers in solution and the length of the polymer chains also affect the time-dependence of the EOF. These results show that the quality of electrophoretic separations can depend on the waiting time between the formation of the coating and the beginning of the separation. We conclude by suggesting experimental tests of our predictions.