Elimination of Perfluorinated Surfactants – Adsorbent Evaluation Applying Surface Tension Measurements

The adsorption of perfluorooctane sulfonate (PFOS) onto activated carbons, nonfunctionalized polymeric adsorbents, and anion exchange resins was evaluated in batch as well as column experiments. It was found that the total PFOS capacity, adsorption kinetics, breakthrough times, and minimum effluent concentrations were highly dependent on the material properties, such as the inner surface area, pore size, functionalization, and hydrophobic character of the material, and on process parameters like temperature and ionic strength of the solution. The experiments furthermore revealed that surface tension measurements are a suitable method for online determination of PFOS concentrations above a defined value.     

Spatial competition and flexible manufacturing with spatially discriminatory pricing

This paper develops a two-dimensional spatial framework, in which firms have the technique of flexible manufacturing and engage in spatially discriminatory pricing, in order to explore the firms’ optimal locations and optimal attributes of basic products under linear transportation costs. The paper shows that the two firms will agglomerate at the center of the location line and the optimal attributes of the two basic products will be located at the first and third quartiles of the attribute line, respectively, when the ratio of the marginal modification rate to the transport rate is high. It also shows that the two firms will locate separately on the location line and that the optimal attributes of the two basic products will remain at the first and third quartiles, when this ratio is moderate. Moreover, this paper proves that the two firms will locate at the first and third quartiles of the location line, respectively, and that the attributes of the basic products will agglomerate at the center of the attribute line, when this ratio is low.     

Hardware architecture of the Protein Processing Associative Memory and the effects of dimensionality and quantisation on performance

The Protein Processor Associative Memory (PPAM) is a novel hardware architecture for a distributed, decentralised, robust and scalable, bidirectional, hetero-associative memory, that can adapt online to changes in the training data. The PPAM uses the location of data in memory to identify relationships and is therefore fundamentally different from traditional processing methods that tend to use arithmetic operations to perform computation. This paper presents the hardware architecture and details a sample digital logic implementation with an analysis of the implications of using existing techniques for such hardware architectures. It also presents the results of implementing the PPAM for a robotic application that involves learning the forward and inverse kinematics. The results show that, contrary to most other techniques, the PPAM benefits from higher dimensionality of data, and that quantisation intervals are crucial to the performance of the PPAM.     

Optimization of environmental impact reduction and economic feasibility of solvent waste recovery using a new software tool

The environmental impact reduction and operating costs savings associated with the purification and recovery of solvent waste in the manufacture of active pharmaceutical ingredients (API's) were investigated. A software toolbox has been developed that combines Aspen Plus^® process simulation with SimaPro^® and Ecosolvent life cycle assessment (LCA) databases. A LCA approach was used in order to consider the environmental impact beyond pharmaceutical production plant boundaries. The feasibility of a relatively small flexible equipment-skid capable of recovering multiple solvent waste streams was evaluated. Distillation and pervaporation were considered to separate binary waste solvent mixtures. Optimum distillation reflux ratio and feed stage were determined to maximize the environmental impact reductions and operating cost savings. The optimum reflux ratio was significantly higher than 1.2 times the minimum reflux ratio suggested by traditional heuristics. The emissions and cost reductions obtained were as much as 49% and 56% higher, respectively, as compared to using the conventional optimum reflux ratio. A comprehensive cash flow analysis showed that the recovery of low volume solvent waste streams is economically feasible, despite traditional thinking. Three case studies from Pfizer are presented to show how our software tool can aid in green engineering decision making.     

Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear

Understanding the pathways involved in the formation and stability of the core and shell regions of a platelet-rich arterial thrombus may result in new ways to treat arterial thrombosis. The distinguishing feature between these two regions is the absence of fibrin in the shell which indicates that in vitro flow-based assays over thrombogenic surfaces, in the absence of coagulation, can be used to resemble this region. In this study, we have investigated the contribution of Syk tyrosine kinase in the stability of platelet aggregates (or thrombi) formed on collagen or atherosclerotic plaque homogenate at arterial shear (1000 s⁻¹). We show that post-perfusion of the Syk inhibitor PRT-060318 over preformed thrombi on both surfaces enhances thrombus breakdown and platelet detachment. The resulting loss of thrombus stability led to a reduction in thrombus contractile score which could be detected as early as 3 min after perfusion of the Syk inhibitor. A similar loss of thrombus stability was observed with ticagrelor and indomethacin, inhibitors of platelet adenosine diphosphate (ADP) receptor and thromboxane A₂ (TxA₂), respectively, and in the presence of the Src inhibitor, dasatinib. In contrast, the Btk inhibitor, ibrutinib, causes only a minor decrease in thrombus contractile score. Weak thrombus breakdown is also seen with the blocking GPVI nanobody, Nb21, which indicates, at best, a minor contribution of collagen to the stability of the platelet aggregate. These results show that Syk regulates thrombus stability in the absence of fibrin in human platelets under flow and provide evidence that this involves pathways additional to activation of GPVI by collagen.     

用于非织造材料的Tencel Lyocell纤维

Lenzing纤维公司开发的Lyocell纤维构成了一个纤维产品系列,用于要求具有吸湿性、纯度、柔软性、强度和生物降解性的各种各样非织造产品.述评了长度短的短纤维(低于20 mm)的特性和制得的织物的性质,重点是如何能利用上述纤维设计高性能非织造材料的重要产品性质.