A Study of Structure Evolution in Pearlitic Steel Wire at Increasing Plastic Deformation

In this work was studied the influence of the plastic deformation's intensity under deep drawing on microstructures of a pearlitic steel containing 0.8% C. Varying the levels of deformation causes diverse dislocation movements as well as modified structural states in the individual phases of the pearlitic eutectoid steel. It is shown that in the course of plastic deformation there is a reduction of interlamellar distance in a pearlite and increase in dislocation density. In some parts partial spheroidisation cementite plates is observed. The bands formed in dislocation structure are found out. The analysis of failure mechanisms of steel with pearlite structure after plastic deformation is carried out. During the deformation of pearlite, the increase in stress at the phase boundary, owing to the elastic strain incompatibility between the ferrite and cementite phases, resembles the stress concentration at grain boundaries. Pores form at the interface between the surface of the ferritic matrix and the spheroidised carbide particles. Such micro pores occur by means of plastic deformation of the ferrite's interstices around the stronger cementite owing to the reduction of the ferritic interstices and their subsequent cracking.     

SK119, a Novel Shikonin Derivative,Leads to Apoptosis in Melanoma Cell Lines and Exhibits Synergistic Effects with Vemurafenib and Cobimetinib

Melanoma is a complex and heterogenous disease, displays the deadliest form of skin cancer, and accounts for approx. 80% of all skin cancer deaths. In this study, we reported on the synthesis and pharmacological effects of a novel shikonin derivative (SK119), which is active in a nano-molar range and exhibits several promising in vitro effects in different human melanoma cells. SK119 was synthesized from shikonin as part of our search for novel, promising shikonin derivatives. It was screened against a panel of melanoma and non-tumorigenic cell lines using XTT viability assays. Moreover, we studied its pharmacological effects using apoptosis and Western blot experiments. Finally, it was combined with current clinically used melanoma therapeutics. SK119 exhibited IC₅₀ values in a nano-molar range, induced apoptosis and led to a dose-dependent increase in the expression and protein phosphorylation of HSP27 and HSP90 in WM9 and MUG-Mel 2 cells. Combinatorial treatment, which is highly recommended in melanoma, revealed the synergistic effects of SK119 with vemurafenib and cobimetinib. SK119 treatment changed the expression levels of apoptosis genes and death receptor expression and exhibited synergistic effects with vemurafenib and cobimetinib in human melanoma cells. Further research indicates a promising potential in melanoma therapy.     

Derivation of imperfect interface models coupling damage and temperature

In this paper we introduce a model describing a layered structure composed by two thermoelastic adherents and a thin adhesive subject to a degradation process. By an asymptotic expansion method, we derive a model of imperfect interface coupling damage and temperature evolution. Moreover, assuming that the behaviour of the adhesive is ruled by two different regimes, one in traction and one in compression, we derive a second limit model where unilateral contact conditions on the interface are also included.     

A generic architecture to synchronise design models issued from heterogeneous business tools: towards more interoperability between design expertises

Product development involves many experts collaborating to the same design goal. Every expert has his own formalisms and tools leading to a high heterogeneity of information systems supporting design activities. Interoperability became a major challenge to avoid information incompatibility along the product life cycle. To synchronise heterogeneous representations of product will be a major step to integrate expert activities. In this paper, the authors propose a meta-model framework to connect together heterogeneous design models. This meta-model framework is used to formalise possible interactions between heterogeneous representations. Interaction formalisation is considered as a key point to synchronise heterogeneous models and to provide more interoperability between various computer assisted systems. The synchronisation loop is also presented as a major sequence of activities to manage collaborative design. Tools to support synchronisation are proposed. However, through a basic case study, authors highlight what can be automated and where human intervention is still expected.     

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