全文获取类型
收费全文 | 19765篇 |
免费 | 1443篇 |
国内免费 | 58篇 |
专业分类
电工技术 | 323篇 |
综合类 | 82篇 |
化学工业 | 5266篇 |
金属工艺 | 376篇 |
机械仪表 | 577篇 |
建筑科学 | 709篇 |
矿业工程 | 62篇 |
能源动力 | 838篇 |
轻工业 | 3651篇 |
水利工程 | 167篇 |
石油天然气 | 117篇 |
无线电 | 1307篇 |
一般工业技术 | 3124篇 |
冶金工业 | 1237篇 |
原子能技术 | 152篇 |
自动化技术 | 3278篇 |
出版年
2024年 | 50篇 |
2023年 | 216篇 |
2022年 | 687篇 |
2021年 | 914篇 |
2020年 | 633篇 |
2019年 | 699篇 |
2018年 | 794篇 |
2017年 | 816篇 |
2016年 | 866篇 |
2015年 | 613篇 |
2014年 | 908篇 |
2013年 | 1549篇 |
2012年 | 1278篇 |
2011年 | 1476篇 |
2010年 | 1093篇 |
2009年 | 1153篇 |
2008年 | 1015篇 |
2007年 | 872篇 |
2006年 | 717篇 |
2005年 | 530篇 |
2004年 | 501篇 |
2003年 | 485篇 |
2002年 | 510篇 |
2001年 | 348篇 |
2000年 | 253篇 |
1999年 | 232篇 |
1998年 | 387篇 |
1997年 | 288篇 |
1996年 | 227篇 |
1995年 | 176篇 |
1994年 | 114篇 |
1993年 | 125篇 |
1992年 | 83篇 |
1991年 | 58篇 |
1990年 | 66篇 |
1989年 | 55篇 |
1988年 | 55篇 |
1987年 | 31篇 |
1986年 | 45篇 |
1985年 | 47篇 |
1984年 | 34篇 |
1983年 | 20篇 |
1982年 | 33篇 |
1981年 | 28篇 |
1980年 | 26篇 |
1979年 | 20篇 |
1978年 | 18篇 |
1977年 | 27篇 |
1976年 | 33篇 |
1975年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
da Silva Breno Augusto Tabosa Thome Pascoalino Liege Aguiar de Souza Ricardo Luiz Muniz Edvani Curti Curti Priscila Schroeder 《Polymer Bulletin》2020,77(3):1157-1176
Polymer Bulletin - In this work, electrospun fibers of poly(butylene adipate-co-terephthalate) (PBAT) and poly(N-isopropylacrylamide) (PNIPAAm) blends, PBAT/PNIPAAm, with different mass ratios,... 相似文献
992.
Lysophosphatidic acid (lysoPtdOH) levels have previously been reported to decrease in rodents with short-term fasting. We investigated whether a 16 h fast would change expression of autotaxin, the predominant phospholipase D responsible for adipose-derived lysoPtdOH synthesis, or any of the lysophosphatidic acid receptors (1–6) in four white adipose tissue (WAT) depots and interscapular brown adipose tissue (BAT) in male C57Bl/6J mice fed ad libitum, or fasted for 16 h. Aside from small inductions of Lpar1 in epididymal WAT and Lpar2 in epididymal and inguinal WAT, no significant changes were observed in expression of the Lpar family members, or autotaxin in perirenal, retroperitoneal, epididymal, or inguinal WAT or BAT with fasting. Comparison of the relative expression of Lpar1-6 in various depots showed that Lpar6 was the predominant Lpar in both WAT and BAT, and suggests that further work on the adipose-specific role of Lpar6 is warranted. 相似文献
993.
de Oliveira Amanda Gerhardt Moreno Janaina Fernandes de Sousa Ana Maria Furtado Esccio Viviane Alves de Oliveira Cavalcanti Guimares Maria Jos da Silva Ana Lucia Nazareth 《Polymer Bulletin》2020,77(6):2889-2904
Polymer Bulletin - Investigating the compatibility mechanism of hybrid composites based on two polymers and one mineral nanofiller is a challenge that needs to be better understood. This study... 相似文献
994.
Raffaele Raimondi Piero Zollet Francesco Paolo De Rosa Panagiotis Tsoutsanis Matteo Stravalaci Marianna Paulis Antonio Inforzato Mario R. Romano 《International journal of molecular sciences》2022,23(2)
The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future. 相似文献
995.
国内某炼钢厂为保证浇注周期较短的2号连铸机连浇,多座转炉需同时向该连铸机供应钢水,导致炉 机对应关系不明确,生产组织难度较大。通过对该厂炼钢 连铸过程的工序作业周期与生产运行模式进行解析,在保证连铸机连浇的基础上,探究合理的炉 机对应关系,改善该厂的生产顺行。结果表明,在“一一对应”运行模式下,2号连铸机最大连浇炉数仅为6炉;而在“定炉对定机”运行模式下,若适时接受3号转炉冶炼的钢水,2号连铸机最大连浇炉数可延长至19炉。在此基础上,通过对连铸机“柔性”的优化和钢水供应的合理调配,2号连铸机可满足实际生产的连浇要求。此外,运用“炉→机”匹配度进行评价,计算结果表明优化后的炉 机对应关系得到显著改善。 相似文献
996.
997.
Flvia Melo Cunha de Pinho Pessoa Caio Bezerra Machado Emerson Lucena da Silva Laudreísa da Costa Pantoja Rodrigo Monteiro Ribeiro Maria Elisabete Amaral de Moraes Manoel Odorico de Moraes Filho Raquel Carvalho Montenegro Andr Salim Khayat Caroline Aquino Moreira-Nunes 《International journal of molecular sciences》2022,23(7)
The increasing numbers of cancer cases worldwide and the exceedingly high mortality rates of some tumor subtypes raise the question about if the current protocols for cancer management are effective and what has been done to improve upon oncologic patients’ prognoses. The traditional chemo-immunotherapy options for cancer treatment focus on the use of cytotoxic agents that are able to overcome neoplastic clones’ survival mechanisms and induce apoptosis, as well as on the ability to capacitate the host’s immune system to hinder the continuous growth of malignant cells. The need to avert the highly toxic profiles of conventional chemo-immunotherapy and to overcome the emerging cases of tumor multidrug resistance has fueled a growing interest in the field of precision medicine and targeted molecular therapies in the last couple of decades, although relatively new alternatives in oncologic practices, the increased specificity, and the positive clinical outcomes achieved through targeted molecular therapies have already consolidated them as promising prospects for the future of cancer management. In recent years, the development and application of targeted drugs as tyrosine kinase inhibitors have enabled cancer treatment to enter the era of specificity. In addition, the combined use of targeted therapy, immunotherapy, and traditional chemotherapy has innovated the standard treatment for many malignancies, bringing new light to patients with recurrent tumors. This article comprises a series of clinical trials that, in the past 5 years, utilized kinase inhibitors (KIs) as a monotherapy or in combination with other cytotoxic agents to treat patients afflicted with solid tumors. The results, with varying degrees of efficacy, are reported. 相似文献
998.
Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo DAlterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto 《International journal of molecular sciences》2022,23(7)
Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains. 相似文献
999.
Diane Cleydes Baía da Silva Leonardo Oliveira Bittencourt Daiane Claydes Baia-da-Silva Victoria Santos Chemelo Luciana Eir-Quirino Priscila Cunha Nascimento Mrcia Cristina Freitas Silva Marco Aurelio M. Freire Walace Gomes-Leal Maria Elena Crespo-Lopez Rafael Rodrigues Lima 《International journal of molecular sciences》2022,23(7)
Methylmercury (MeHg) is one of the most dangerous toxic pollutants spread throughout the earth. Chronic MeHg intoxication by contaminated food ingestion is the most common threat to human health, including impairment to the developing fetus. The present study aims at investigating the effects of maternal exposure to MeHg during gestation and lactation on the spinal cord of offspring. Pregnant rats received oral doses of MeHg (40 μg/kg/day) over a period of 42 days (21 gestation and 21 lactation). Control animals received the vehicle only. Total mercury concentration was measured in blood samples from offspring collected at the 41st postnatal day. Counting of motor neurons and immunoreactivity for myelin basic protein (MBP) were assessed in the spinal cords in both control and MeHg-intoxicated animals. Our results showed that MeHg promoted an increase in blood Hg levels. In addition, it caused a reduction in the number of spinal cord motor neurons as well as decreased MBP immunoreactivity in the cervical, thoracic and lumbar segments. Our present findings suggest that MeHg intoxication during rat pregnancy and lactation is associated with a pattern of motor neuron degeneration and downregulation of myelin basic protein in different segments of a developing spinal cord. Further studies are needed to establish the effect of MeHg intoxication in both young and adult rats. 相似文献
1000.
Elena Bresciani Nicola Squillace Valentina Orsini Roberta Piolini Laura Rizzi Laura Molteni Ramona Meanti Alessandro Soria Giuseppe Lapadula Alessandra Bandera Andrea Gori Paolo Bonfanti Robert John Omeljaniuk Vittorio Locatelli Antonio Torsello 《International journal of molecular sciences》2022,23(7)
Combined AntiRetroviral Treatments (cARTs) used for HIV infection may result in varied metabolic complications, which in some cases, may be related to patient genetic factors, particularly microRNAs. The use of monozygotic twins, differing only for HIV infection, presents a unique and powerful model for the controlled analysis of potential alterations of miRNAs regulation consequent to cART treatment. Profiling of 2578 mature miRNA in the subcutaneous (SC) adipose tissue and plasma of monozygotic twins was investigated by the GeneChip® miRNA 4.1 array. Real-time PCR and ddPCR experiments were performed in order to validate differentially expressed miRNAs. Target genes of deregulated miRNAs were predicted by the miRDB database (prediction score > 70) and enrichment analysis was carried out with g:Profiler. Processes in SC adipose tissue most greatly affected by miRNA up-regulation included (i) macromolecular metabolic processes, (ii) regulation of neurogenesis, and (iii) protein phosphorylation. Furthermore, KEGG analysis revealed miRNA up-regulation involvement in (i) insulin signaling pathways, (ii) neurotrophin signaling pathways, and (iii) pancreatic cancer. By contrast, miRNA up-regulation in plasma was involved in (i) melanoma, (ii) p53 signaling pathways, and (iii) focal adhesion. Our findings suggest a mechanism that may increase the predisposition of HIV+ patients to insulin resistance and cancer. 相似文献