Recently distributed real-time database systems are intended to manage large volumes of dispersed data. To develop distributed real-time data processing, a reality and stay competitive well defined protocols and algorithms must be required to access and manipulate the data. An admission control policy is a major task to access real-time data which has become a challenging task due to random arrival of user requests and transaction timing constraints. This paper proposes an optimal admission control policy based on deep reinforcement algorithm and memetic algorithm which can efficiently handle the load balancing problem without affecting the Quality of Service (QoS) parameters. A Markov decision process (MDP) is formulated for admission control problem, which provides an optimized solution for dynamic resource sharing. The possible solutions for MDP problem are obtained by using reinforcement learning and linear programming with an average reward. The deep reinforcement learning algorithm reformulates the arrived requests from different users and admits only the needed request, which improves the number of sessions of the system. Then we frame the load balancing problem as a dynamic and stochastic assignment problem and obtain optimal control policies using memetic algorithm. Therefore proposed admission control problem is changed to memetic logic in such a way that session corresponds to individual elements of the initial chromosome. The performance of proposed optimal admission control policy is compared with other approaches through simulation and it depicts that the proposed system outperforms the other techniques in terms of throughput, execution time and miss ratio which leads to better QoS.
In order to identify risk of inadequate intake of calories and nutrients during pregnancy, 75 pregnant adolescents (14 to 18 years old) apparently healthy, from low socioeconomic level, in their first prenatal control (12 weeks) were studied by two 24 hour recalls and a food frequency questionnaire at each trimester. Nutritional status was assessed by body mass index (pregestation weight/height) and classified according to American Medicine Institute reference. Paired t-test, frequency distribution and ANOVA were used for statistical analysis. Low weight was found in 34.6% of adolescent at the first visit and 5.3% were overweight. Even though, caloric intake was below recommendation, significant increases were observed between first and second trimester for energy, carbohydrates, niacin and zinc (p < 0.001) and for fat, proteins, riboflavin, thiamin, vitamin C, calcium and iron (p < 0.05). From second to third trimester, differences (p < 0.05) were significant only for vitamin A. Between first and third trimester, differences were significant (p < 0.05) for energy, proteins, carbohydrates, niacin, riboflavin, zinc and for thiamin, vitamin A and calcium (p < 0.05). A high proportion of pregnant adolescent did not reach recommendations for energy, folate, calcium and zinc. Food intake pattern did not change significantly among trimesters. Mean total weight gain was 9.2 kg and 0.412 +/- 0.4 g/week. Newborn's mean weight was 3.221 +/- 418 grams. It is concluded that adolescents are at high nutritional risk and deficiency of dietary intake should be followed. Attention should be addressed from the preconceptional period to postpartum in order to improve maternal and fetal conditions. 相似文献
We describe a proof method that characterises a family of proofs corresponding to the synthesis of recursive functional programs. This method provides a significant degree of automation in the construction of recursive programs from specifications, together with correctness proofs. This method makes use of meta-variables to allow successive refinement of the identity of unknowns, and so allows the program and the proof to be developed hand in hand. We illustrate it with parts of a substantial example—the synthesis of a unification algorithm. 相似文献
Fritillaria bulbs are used in Traditional Chinese Medicine to treat several illnesses. Peimine (Pm), an anti-inflammatory compound from Fritillaria, is known to inhibit some voltage-dependent ion channels and muscarinic receptors, but its interaction with ligand-gated ion channels remains unexplored. We have studied if Pm affects nicotinic acetylcholine receptors (nAChRs), since they play broad functional roles, both in the nervous system and non-neuronal tissues. Muscle-type nAChRs were incorporated to Xenopus oocytes and the action of Pm on the membrane currents elicited by ACh (IAChs) was assessed. Functional studies were combined with virtual docking and molecular dynamics assays. Co-application of ACh and Pm reversibly blocked IACh, with an IC50 in the low micromolar range. Pm inhibited nAChR by: (i) open-channel blockade, evidenced by the voltage-dependent inhibition of IAch, (ii) enhancement of nAChR desensitization, revealed by both an accelerated IACh decay and a decelerated IACh deactivation, and (iii) resting-nAChR blockade, deduced from the IACh inhibition elicited by Pm when applied before ACh superfusion. In good concordance, virtual docking and molecular dynamics assays demonstrated that Pm binds to different sites at the nAChR, mostly at the transmembrane domain. Thus, Pm from Fritillaria bulbs, considered therapeutic herbs, targets nAChRs with high affinity, which might account for its anti-inflammatory actions. 相似文献
There is recognition that both stress and immune responses are important factors in a variety of neurological disorders. Moreover, there is an important role of several neurotransmitters that connect these factors to several neurological diseases, with a special focus in this paper on serotonin. Accordingly, it is known that imbalances in stressors can promote a variety of neuropsychiatric or neurodegenerative pathologies. Here, we discuss some facts that link major depressive disorder, Alzheimer’s, and Parkinson’s to the stress and immune responses, as well as the connection between these responses and serotonergic signaling. These are important topics of investigation which may lead to new or better treatments, improving the life quality of patients that suffer from these conditions. 相似文献