Multicriteria decisions on interdependent infrastructure transportation projects using an evolutionary-based framework

When evaluating transportation infrastructure projects and determining which of them will be carried out from a set of projects and given a budget constraint, several criteria need to be considered in the decision. Standard evaluation practices imply the aggregation of impacts into one utility function which is later optimized. Nevertheless these techniques used for translation of different measuring units into monetary terms are highly controversial. Multicriteria techniques can explicitly deal with different measuring units, however, they are not suitable to model interdependence relationships of projects that share a common characteristic (same route, location or target population, for instance). In this research we model this transportation planning problem, the multi-objective transportation infrastructure project selection problem (MTIPSP), as a constrained multi-objective optimization problem with quadratic objective functions, using a variation of the multi-objective 0–1 knapsack problem plus some additional constraints. Given the combinatorial nature of the problem, an evolutionary-based framework is used for the identification of Pareto solutions, and later, those with non-attractive properties are filtered using a Knee Identification Procedure. The final selection of the projects portfolio is made using a well known multicriteria decision aid method and including the decision makers’ preferences based on the existing context.     

Efficient simulation of tissue-like P systems by transition cell-like P systems

In the framework of P systems, it is known that the construction of exponential number of objects in polynomial time is not enough to efficiently solve NP-complete problems. Nonetheless, it could be sufficient to create an exponential number of membranes in polynomial time. Working with P systems whose membrane structure does not increase in size, it is known that it is not possible to solve computationally hard problems (unless P = NP), basically due to the impossibility of constructing exponential number of membranes, in polynomial time, using only evolution, communication and dissolution rules. In this paper we show how a family of recognizer tissue P systems with symport/antiport rules which solves a decision problem can be efficiently simulated by a family of basic recognizer P systems solving the same problem. This simulation allows us to transfer the result about the limitations in computational power, from the model of basic cell-like P systems to this kind of tissue-like P systems.     

An Interoperable Grid Information System for Integrated Resource Monitoring Based on Virtual Organizations

In many Grid infrastructures different kinds of information services are in use, which utilize different incompatible data structures and interfaces to encode and provide their data. Homogeneous monitoring of these infrastructures with the monitoring data being accessible everywhere independently of the middleware which provided it, is the basis for a consistent status reporting on the Grids’ resources and services. Thus, interoperability or interoperation between the different information services in a heterogeneous Grid infrastructure is required. Monitoring data must contain the identity of the affected Virtual Organization (VO) so that it can be related to the resources and services the VO has allocated to enable VO-specific information provision. This paper describes a distributed architecture for an interoperable information service, which combines data unification and categorization with policies for VO membership, VO resource management and data transformations. This service builds the basis for an integrated and interoperating monitoring of Grids, which provide their data to more than one VO and utilize heterogeneous information services.     

Acclimatization model of an aerobic bioreactor for the treatment of toxic wastewater

This work proposes a mathematical model for the acclimatization process of a bioreactor treating toxic wastewater. Experimental data was used to identify the changing kinetic parameters of the model as acclimatization progresses. It was found that only one key parameter, the specific biomass growth rate function, changed during the acclimatization process. Therefore, an acclimatization model was proposed to explain the changes of this parameter.     

AC electrokinetic pumping on symmetric electrode arrays

AC electro-osmotic (ACEO) pumping is experimentally demonstrated on a symmetric gold electrode array. Using asymmetric connection of electrodes to the applied AC voltage, spatial asymmetry along the array is created, which produces unidirectional flow of electrolyte. An aqueous solution of 100 μM KCl is selected as the pumping fluid. The liquid velocity obtained as a function of voltage and frequency is compared to that generated using travelling-wave electroosmosis (TWEO) with the same electrode array. The expected velocities from the linear electrokinetic models of ACEO and TWEO are computed numerically. The comparison shows that TWEO generates greater velocity amplitudes and the streamlines are smoother than those generated by ACEO.     

Understanding users and their needs

Gaze-control enables people to control a computer by using eye-gaze to select items on screen. Gaze-control is a necessity for people who have lost all motor control of their body and only have control over eye movements. In addition, gaze-control can be the quickest and least tiring option for a far broader group of people with varying disabilities. This paper reports findings from gaze-control user trials involving users from both groups: people who are totally paralyzed, as well as people with a wide range of complex disabilities. The trials conducted involved four different centres supporting people with disabilities in three different European countries. Several gaze-control systems were trialled by a large number of users with varying needs and abilities. The perceived benefits of gaze-control are described, and recommendations for successful assessment and implementation of gaze-control are provided.     

Metamodeling live sequence charts for code generation

This article presents a metamodeling study for Live Sequence Charts (LSCs) and Message Sequence Charts (MSCs) with an emphasis on code generation. The article discusses specifically the following points: the approach to building a metamodel for MSCs and LSCs, a metamodel extension from MSC to LSC, support for model-based code generation, and finally action model and domain-specific data model integration. The metamodel is formulated in metaGME, the metamodel language for the Generic Modeling Environment.

Charting online OMICS resources: A navigational chart for clinical researchers

The life sciences have sprouted several popular and successful OMICS technologies that span all levels of biological information transfer. Ever since the start of the Human Genome Project, the then revolutionary idea to make all resulting data publicly available has been central to all of the efforts across OMICS technologies. As a result, a great variety of publicly available data repositories and resources is currently available to the research community. This widespread availability of data does come at the price of increased confusion on the part of the users, especially for those that see the OMICS technologies as tools to help unravel a larger biological or clinical question. We therefore provide a comprehensive overview of the available resources across OMICS fields, with a special emphasis on those databases that are relevant to the study of proteins. Additionally, we also describe various integrative systems that have been established, and highlight new developments in the field that can revolutionize the way in which live data integration is achieved over the internet.     

Proteomics identification of differentially expressed proteins in the muscle of dysferlin myopathy patients

The muscular dystrophies are a large and heterogeneous group of neuromuscular disorders that can be classified according to the mode of inheritance, the clinical phenotype and the molecular defect. To better understand the pathological mechanisms of dysferlin myopathy we compared the protein-expression pattern in the muscle biopsies of six patients with this disease with six patients with limb girdle muscular dystrophy 2A, five with facioscapulohumeral dystrophy and six normal control subjects. To investigate differences in the expression levels of skeletal muscle proteins we used 2-DE and MS. Western blot or immunohistochemistry confirmed relevant results. The study showed specific increase expression of proteins involved in fast-to-slow fiber type conversion (ankyrin repeat protein 2), type I predominance (phosphorylated forms of slow troponin T), sarcomere stabilization (actinin-associated LIM protein), protein ubiquitination (TRIM 72) and skeletal muscle differentiation (Rho-GDP-dissociation inhibitor ly-GDI) in dysferlin myopathy. As anticipated, we also found differential expression of proteins common to all the muscular dystrophies studied. This comparative proteomic analysis suggests that in dysferlin myopathy (i) the type I fiber predominance is an active process of fiber type conversion rather than a selective loss of type II fibers and (ii) the dysregulation of proteins involved in muscle differentiation further confirms the role of dysferlin in this process.