A fuzzy reasoning and fuzzy-analytical hierarchy process based approach to the process of railway risk information: A railway risk management system

Risk management is becoming increasingly important for railway companies in order to safeguard their passengers and employees while improving safety and reducing maintenance costs. However, in many circumstances, the application of probabilistic risk analysis tools may not give satisfactory results because the risk data are incomplete or there is a high level of uncertainty involved in the risk data. This article presents the development of a risk management system for railway risk analysis using fuzzy reasoning approach and fuzzy analytical hierarchy decision making process. In the system, fuzzy reasoning approach (FRA) is employed to estimate the risk level of each hazardous event in terms of failure frequency, consequence severity and consequence probability. This allows imprecision or approximate information in the risk analysis process. Fuzzy analytical hierarchy process (fuzzy-AHP) technique is then incorporated into the risk model to use its advantage in determining the relative importance of the risk contributions so that the risk assessment can be progressed from hazardous event level to hazard group level and finally to railway system level. This risk assessment system can evaluate both qualitative and quantitative risk data and information associated with a railway system effectively and efficiently, which will provide railway risk analysts, managers and engineers with a method and tool to improve their safety management of railway systems and set safety standards. A case study on risk assessment of shunting at Hammersmith depot is used to illustrate the application of the proposed risk assessment system.     

The development of multiple reaction monitoring assays for liver-derived plasma proteins

There is wide interpatient variability in toxicity to chemotherapeutic drugs and a lack of routine clinical tests for prospectively identifying patients at risk of developing toxicity from chemotherapy. An empirically driven MS strategy has been developed to monitor liver-derived plasma proteins as potential biomarkers of early toxicity. Multiple reaction monitoring (MRM) has been used to assess 46 candidate peptides from 18 liver-derived proteins. Following an iterative process of assay design, optimisation and assessment we selected 29 MRM assays (median CV 4.6%, range 1.2-11.6%) and monitored changes in levels of plasma proteins from a small number of colorectal cancer (CRC) patients undergoing chemotherapy. We demonstrated MRM assay robustness, and show that patients undergo minor elevation in plasma proteins when profiled on Day 3 of the chemotherapeutic regime. The MRM assays were in general agreement with 2-D DIGE-based quantitation from the same patient samples. The data supports the application of MRM-based methods as facile, highly reproducible, medium-throughput techniques that warrant expanded investigation for clinical utility in identifying patients at risk of developing chemotoxicity.     

Texture study of two molybdenum shaped charge liners by neutron diffraction

The textures of two different conical shaped liners, fabricated by the same forging processes from arc-cast and powder-sintered ingots, were investigated by using neutron-diffraction measurements and three-dimensional orientation-distribution-function (ODF) analysis. The major textures of both liners could be described by the (1 1 1) uv w and (1 0 0) u v w type. The two liners had essentially identical texture at the 8 cm position (measured from the base of the cone) with strong sheet-type texture components, i.e. (1 1 1) ¯1 0 1, (1 1 1) ¯1 1 0 and (1 0 0) 0 1 1. However, the dominant textures at the 3 cm positions were 1 1 1 and 1 0 0 fibre textures with the fibre axes oriented parallel to the normal direction in both liners. A strong cube texture was observed at the 3 cm position of the arc-cast liner but it was not observed for the powder-sintered liner. The arc-cast liner had a generally higher degree of texture than the powder-sintered liner.     

Conductivity measurements on liquid sulphur

The electrical conductivity of liquid sulphur has been measured from the melting point to 900° C, evaporation of the sulphur being prevented by use of an atmosphere of argon at elevated pressure. With rise in temperature, the conductivity increases except at the polymerization maximum near 170° C where a minimum in the conductivity is confirmed. Above 400° C the plot of log versus 1/T is linear, and on the assumption that the conductivity at these temperatures is intrinsic, a value of 3.1 eV is obtained for the energy gap. Although the rise in conductivity above 400° C is accompanied by a decrease in mean chain length in the liquid, there is no simple relationship between the two properties. The behaviour of sulphur is compared with that of liquid selenium.     

Synthetic pyrethroid insecticides as replacements for chlorinated hydrocarbons for the control of wood-boring insects

The need for effective contact insecticides to replace γ-HCH and dieldrin is discussed. Four synthetic pyrethroids, permethrin, cypermethrin, decamethrin and fenvalerate were evaluated for control of the house longhorn beetle,Hylotrupes bajulus and the common furniture beetleAnobium punctatum. Permethrin was also tested againssLyctus brunneus and the termiteReticulitermes santonensis. Initial toxic effectiveness of all 4 pyrethroids was similar to or in the case of decamethrin, markedly better than γ-HCH and with the exception of fenvalerate their persistence in wood was superior to γ-HCH. They offer hopeful potential replacements for chlorinated hydrocarbons but further evaluation is necessary.     

A Digitally Controlled Stimulator for Neurophysiological Applications

A stimulator circuit is presented which is capable of generating pulse train waveforms suitable for neurophysiological experiments are available, as well as special test conditions such as dishabituation. Digital and linear integrated circuits are used to provide precise control over the stimulus parameters.     

Precise lattice parameter determination of dislocation-free gallium arsenide—II: Chemical and electrical measurements

Precise lattice parameter measurements on dislocation-free gallium arsenide were described in Part I (preceding paper).² Detailed chemical and electrical analyses of the same samples are described here. The predictions of simple chemical models are developed in the light of the analytical results. The significant observed increase in lattice parameter due to silicon doping, in contrast to the predicted decrease, is discussed.     

Professional drivers: protection needed for a high-risk occupation

"On the job" motor vehicle deaths number more than 4,000 annually in the U.S. and comprise nearly one-third of all work-related deaths. Yet the Department of Labor has set no standards relating to on-the-road safety of the millions of workers whose jobs entail large amounts of driving, and Department of Transportation standards affecting occupational safety cover only drivers in interstate commerce. Drivers of some commercial vehicles, such as heavy trucks, are at special risk of injury because trucks have usually been exempted for many years from federal motor vehicle safety standards--such as standards for brakes and seatbelts--designed to prevent crashes or protect occupants in crashes. Observations based on a series of 150 fatal crashes involving tractor trailers illustrate the need for better protection of this large population of high-risk workers. Clarification of responsibility within the various federal agencies and application of available knowledge and technology are essential.