Psychological effects of liver disease and transplantation

Psychological adjustment in children with liver disease was investigated. Three groups of children 6-15 years old participated: ten had undergone a liver transplant (Gp1), 15 had ongoing chronic liver disease (Gp2) and 15 were healthy controls (Gp3). Children who had had a transplant appeared well adjusted and thought of themselves as healthy rather than ill, although areas of vulnerability were present, for example increased anxiety. No differences emerged in terms of coping with common or illness-related problems or understanding of the causes of illness and use of medication. Gps 1 and 2 showed higher levels of understanding of the functions of the liver but less understanding of illness prevention when compared to their healthy peers. Gp2 experienced less control over their health when compared to the other two groups. Gp1 rated themselves as more "healthy" than Gp2 but less so than Gp3. CONCLUSION: Children with chronic liver disease are able to communicate how they deal with the stresses of the condition. Though well adjusted in many ways, those who have had a transplant still show areas of psychological vulnerability which need to be addressed in clinical practice.     

Universal Approximation Theorem for Interval Neural Networks

One of the main computer-learning tools is an (artificial) neural network (NN); based on the values y ^(p) of a certain physical quantity y at several points x ^(p) =(x ₁ ^(p) ,...,x _n ^(p) ), the NN finds a dependence y = f(x₁,...,x _n ) that explains all known observations and predicts the value of y for other x = (x1,...,xn). The ability to describe an arbitrary dependence follows from the universal approximation theorem, according to which an arbitrary continuous function of a bounded set can be, within a given accuracy, approximated by an appropriate NN.The measured values of y are often only known with interval uncertainty. To describe such situations, we can allow interval parameters in a NN and thus, consider an interval NN. In this paper, we prove the universal approximation theorem for such interval NN's.     

An analysis of global edf schedulability for arbitrary-deadline sporadic task systems

Recent results on the global multiprocessor edf scheduling of sporadic task systems are, for the most part, applicable only to task systems in which each task’s relative deadline parameter is constrained to be no larger than its minimum inter-arrival separation. This paper introduces new analysis techniques that allow for similar results to be derived for task systems in which individual tasks are not constrained in this manner. For tasks with deadlines greater than their minimum inter-arrival separation, two models are considered, with and without an implicit intra-task job precedence constraint. The new analyses yield schedulability conditions that strictly dominate some previously proposed tests that are generally accepted to represent the current state of the art in multiprocessor edf schedulability analysis, and permits the derivation of an improved speed-up bound.

Robust Software for Computing Camera Motion Parameters

We revisit the method of Tsai, Huang, and Zhu for the computation of camera motion parameters in computer vision. We elucidate some spectral properties of the homography matrices that arise, which are rank-one perturbations of rotation matrices. We show how to correct for noise by finding the rank-one perturbation of a rotation closest to a given matrix. We illustrate some of the inaccuracies and computational failures that can arise when using the formulas given by Tsai, and we propose new formulas that avoid these pitfalls. A computational experiment shows that the new methods are indeed quite robust.

Predicting adolescents’ use of social networking sites from an extended theory of planned behaviour perspective

The popularity of social networking sites (SNSs) among adolescents has grown exponentially, with little accompanying research to understand the influences on adolescent engagement with this technology. The current study tested the validity of an extended theory of planned behaviour model (TPB), incorporating the additions of group norm and self-esteem influences, to predict frequent SNS use. Adolescents (N = 160) completed measures assessing the standard TPB constructs of attitude, subjective norm, perceived behavioural control (PBC), and intention, as well as group norm and self-esteem. One week later, participants reported their SNS use during the previous week. Support was found for the standard TPB variables of attitude and PBC, as well as group norm, in predicting intentions to use SNS frequently, with intention, in turn, predicting behaviour. These findings provide an understanding of the factors influencing frequent engagement in what is emerging as a primary tool for adolescent socialisation.     

Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles)

Policies supporting the rapid and open sharing of proteomic data are being implemented by the leading journals in the field. The proteomics community is taking steps to ensure that data are made publicly accessible and are of high quality, a challenging task that requires the development and deployment of methods for measuring and documenting data quality metrics. On September 18, 2010, the U.S. National Cancer Institute (NCI) convened the "International Workshop on Proteomic Data Quality Metrics" in Sydney, Australia, to identify and address issues facing the development and use of such methods for open access proteomics data. The stakeholders at the workshop enumerated the key principles underlying a framework for data quality assessment in mass spectrometry data that will meet the needs of the research community, journals, funding agencies, and data repositories. Attendees discussed and agreed up on two primary needs for the wide use of quality metrics: (i) an evolving list of comprehensive quality metrics and (ii) standards accompanied by software analytics. Attendees stressed the importance of increased education and training programs to promote reliable protocols in proteomics. This workshop report explores the historic precedents, key discussions, and necessary next steps to enhance the quality of open access data. By agreement, this article is published simultaneously in Proteomics, Proteomics Clinical Applications, Journal of Proteome Research, and Molecular and Cellular Proteomics, as a public service to the research community. The peer review process was a coordinated effort conducted by a panel of referees selected by the journals.     

Tycho: a wide-area messaging framework with an integrated virtual registry

In a distributed environment remote entities, usually the producers or consumers of services, need a means to publish their existence so that clients, needing their services, can search and find the appropriate ones that they can then interact with directly. The publication of information is via a registry service, and the interaction is via a high-level messaging service. Typically, separate libraries provide these two services. Tycho is an implementation of a wide-area asynchronous messaging framework with an integrated distributed registry. This will free developers from the need to assemble their applications from a range of potentially diverse middleware offerings, which should simplify and speed application development and more importantly allow developers to concentrate on their own domain of expertise. In the first part of the paper we outline our motivation for producing Tycho and then review a number of registry and messaging systems popular with the Grid community. In the second part of the paper we describe the architecture and implementation of Tycho. In the third part of the paper we present and discuss various performance tests that were undertaken to compare Tycho with alternative similar systems. Finally, we summarise and conclude the paper and outline future work.

Curriculum revision: reaching faculty consensus through the Nominal Group Technique

A fundamental concept to initiate change in the curriculum revision process is to overcome resistance to change and the boundaries of self-interest. Curriculum change cannot occur without an "unfreezing" of faculty values and interests. The Nominal Group Technique (NGT) was used to facilitate faculty identification of areas needing change in the undergraduate nursing curriculum. The process led to the generation of numerous independent ideas in which all faculty participated. The revised curriculum which resulted from the NGT process has had full and enthusiastic support of the faculty.     

Physical activity and minority women: a qualitative study

Few physical activity research studies have been conducted with minority women. The purpose of this study was to explore patterns of physical activity among minority women. Focus groups were conducted with volunteers older than age 40. Each group was led by a trained moderator familiar with the ethnic community targeted. The sessions were audiotaped and professionally transcribed. Constructs were researched and codes were developed. Data were analyzed using NUD*IST qualitative analysis program. While participants did not identify themselves as "exercisers," they indicated they got enough physical activity from caregiving, housekeeping, and workday activities. The most common environmental barriers to becoming more physically active included safety, availability, and cost. Personal barriers included lack of time, health concerns, and lack of motivation. Results indicate the importance of terminology and assessment when conducting physical activity research in these populations. Also, results suggest many barriers are changeable with policies and interventions.