Experimental Electrohydrodynamic Nanospray Production Using Drawn Glass Capillaries

This article describes a simple and low-cost method of fabricating glass capillary nanospray emitter sources, and, if required, inserting a charging electrode. Initial experimental work employing such a source is described, whose results suggest that whilst the positioning of the charging electrode relative to the orifice influences the charging current and spray considerably, this position may not correspond with that previously reported as being ideal for electrospray systems one or two orders of magnitude greater.     

Defective repair of oxidative damage in mitochondrial DNA in Down''s syndrome

BACKGROUND: Synthetic homopyrimidine peptide nucleic acids (PNAs) can bind complementary targets in double-stranded DNA, generating strand-displacement complexes, and so offering an opportunity to modulate specific gene expression. Several issues remain to be addressed before these attributes can be exploited in vivo, however. RESULTS: The kinetics of the interaction between a homopyrimidine PNA and a complementary homopurine target on double-stranded DNA were analyzed in the presence or absence of a preformed strand-displacement complex proximal to the target. The complex was established under low salt conditions by the binding of a different homopyrimidine PNA to a target situated adjacent to the first PNA target. These two targets were placed next to each other on opposite strands at distances of 0, 2, 4 and 8 base pairs apart. The presence of a preformed strand-displacement complex near the target accelerates the binding of PNA to double-stranded DNA in a salt-dependent manner. The influence of salt on the binding rates was also examined. The binding rate is increased by a factor of 1 x exp(70[NaCl]), that is, 16-fold at 40 mM NaCl and more than 10(4)-fold if extrapolated to 140 mM NaCl. This effect is significantly reduced if the two targets are 2 base pairs apart and completely absent if the distance is 4 base pairs or more. CONCLUSIONS: The perturbation of the DNA helix imposed by a PNA strand-displacement complex only propagates a few base pairs. It is therefore possible to target sites in the immediate vicinity of strand invasion complexes specifically. The results presented have implications for the mechanism of strand displacement and for the application of PNA in a genomic context.     

Fabrication and Electromechanical Characterization of Silver-Clad BSCCO Tapes

The powder-in-tube technique consisting of industrial processes such as wire drawing and rolling has been widely used to fabricate superconducting tapes. In the present investigation a novel technique was adopted to fabricate BSCCO 2223 tapes. Instead of wire drawing, the silver billet was reduced in size by groove rolling. Stress conditions during groove rolling were analyzed and appropriate changes were incorporated to optimize the deformation process. Subsequent thermomechanical treatment resulted in tapes with average critical current densities of 18,000 A/cm². Phase development and microstructural evolution during the thermomechanical treatment were studied using XRD, SEM, and TEM. The electromechanical properties of monofilament and composite BSCCO tapes were evaluated by subjecting them to in situ tensile tests. The strain tolerance of the composite was found to be better than that of the monofilament BSCCO tape.     

Flow properties of thermally depolymerized liquid natural rubber

The flow behavior of liquid natural rubber (LNR) with reference to the effect of molecular weight, shear rate, and temperature has been studied. LNR samples were prepared by thermal depolymerization of rubber (NR) through the combined effect of mechanical, chemical, and thermal energies. High molecular weight samples, especially at lower temperatures, showed pseudoplastic behavior, whereas the low molecular weight samples were Newtonian at all temperatures. The viscosity of LNR considerably decreases with increase in temperature. The activation energy of flow was also calculated. © 1995 John Wiley & Sons, Inc.     

Ba2HoNbO6: A new perovskite ceramic substrate for superconducting YBa2Cu3O7−δ thick film (T c (0) = 92 K)

A complex perovskite oxide Ba₂HoNbO₆ has been developed as a non-reacting substrate for YBa₂Cu₃O_7– superconducting film with lattice constant a = 8.3905 Å. The dielectric constant (30) and loss factor value (5 × 10^–3) of the material are in the range suitable for its use as substrate for microwave applications. A YBa₂Cu₃O_7–delta; superconducting thick film dip coated on Ba₂HoNbO₆ substrate gave a T _c(0) of 92 K and current density of 1.2 × 10⁴ A cm^–2.     

Validation of biokinetic models of Cs and I using their daily dietary intakes and organ contents in an adult Indian population

The daily dietary intakes and total contents of Cs and I in skeletal muscle and thyroid, respectively, for an average Indian adult were estimated by determining their concentrations in the total cooked diet and tissue samples using instrumental neutron activation analysis. These data were then used to predict the biological half-lives of Cs and I and their radioactive counterparts for the Reference Indian Man. The predicted biological half-lives of Cs and I for Reference Indian Man were found to be comparable with the reported values for the ICRP Reference Man.     

Effect of low-density filler on mechanical properties of syntactic foams of cyanate ester

Syntactic foam composites of cyanate ester with varying volume fractions of resin and glass microballoon were processed and evaluated for tensile, flexural and compressive properties. The effect of nature and volume fraction of microballoon on the mechanical properties was studied. The mechanical properties showed a gradual decrease in strength with increase in volume fraction of microballoon. The specific strength values also manifested a similar order. A similar behaviour was observed for syntactic foams with microballoons of varying true density. The properties increased proportional to the strength of the microballoon in resin-rich systems implying a strong microballoon-resin interface, corroborated by Scanning Electron Microscopy studies. The compressive modulus showed a decreasing trend with enhanced microballoon loading.     

Compact Models of Spreading Resistances for Electrical/Thermal Design of Devices and ICs

Building upon our recent work (IEEE Electron Device Lett., vol. 26, pp. 909-912, Dec, 2005), we present simple and continuous closed-form models for several rectangular and circular spreading resistance geometries encountered in electrical/thermal design of devices and integrated circuits. The resistance geometries considered involve current/heat flow between parallel contacts of rectangular or circular shape and concentric or eccentric nature, between a horizontal and a vertical stripe, and between a horizontal circular contact and a surrounding vertical cylindrical contact. The modeling procedure involves normalization of the spreading resistance with respect to its value under 1D flow conditions, followed by a curve-fit of the variation of this normalized resistance with contact area in terms of physical parameters. The resistance models may also be used to estimate the reciprocal of capacitance of similar insulator-electrode geometries, by replacing the resistivity by the reciprocal of the insulator permittivity.     

Production inventory with service time and interruptions

This paper considers an (s,S) production inventory system with positive service time, with time for producing each item following Erlang distribution. Customers arrive according to a Poisson process. A customer who arrives when there is no inventory in the system is considered lost. On the other hand, a customer who finds a busy server with at least one inventory in the system joins a queue of infinite capacity. When the inventory level falls to s, production process is switched on, and it is switched off when the inventory level reaches back to S. Service time to each customer also follows an Erlang distribution. The service of a customer may be interrupted, where the time for such a phenomenon follows an exponential distribution, whenever it occurs. An interrupted service, after repair, resumes from where it was stopped. The correction/repair time follows an exponential distribution. We assume that the service of a single customer may encounter any number of interruptions and that the customer being served waits there until his service is completed. Moreover, at a time the server is subject to at most one interruption. We also assume that no inventory is lost due to a service interruption. Like the service process, the production process also is subject to interruptions, where the duration to an interruption follows an exponential distribution. However, in contrast to the service interruption, in the case of interruption to production process, we assume that the item being processed is lost because of interruption. That is, the production process, on being interrupted, restarts from the beginning, after repair. The repair time of an interrupted production process follows exponential distribution. Few of the last service phases are assumed to be protected in the sense that the service will not be interrupted while being in these phases. The same is assumed for the production process also.

The model is analysed as a level-independent quasi-birth–death process. We apply a novel method to obtain an explicit expression for the necessary and sufficient condition for the stability of the system under study. This method works even if we assume general phase-type distributions for the production as well as the service processes, and hence can be used to characterise the stability of inventory systems where the assumption of disallowing the customers to join the system, when there is a shortage of inventory has been made. Under stability, we apply matrix analytic methods to compute the system state distribution. In consequence to that, several system performance measures have been derived, and their dependence on the system parameters has been studied numerically.     

Controllability of stochastic integrodifferential systems

In this paper sufficient conditions for the complete controllability of a stochastic semilinear integrodifferential system in finite dimensional spaces are established using the resolvent matrix and the Banach fixed point theorem. An example is provided to illustrate the result.