Hepatic damage produced by long-term alcohol consumption in well-nourished rats

A study of the effect of long-term alcohol consumption on the liver of well-nourished rats is described. Rats fed for 16 weeks on a semipurified diet supplemented with high levels of vitamins and lipotropic factors and alcohol corresponding to 35% of the total caloric intake developed marked fatty changes of the liver. Mild fatty changes were observed in pair-fed controls receiving as isoenergetic equivalent of sucrose instead of alcohol. Intracellular hyaline bodies, corresponding ultrastructurally to giant mitochondria were abundantly found in the hepatocytes of alcoholic rats, while in the controls they were not seen. Te findings in this investigation are postulated to provide further evidence that the long-term intake of alcohol exerts a direct causative role in the pathogenesis of liver damage.     

Bücherschau

Ohne Zusammenfassung VDI     

Modeling of Filtration Combustion of Carbon

The kinetics of the overall reactions of carbon gasification at temperatures up to 1600 K is studied. The kinetic characteristics of the reactions are taken into account in a distributed mathematical model of filtration combustion of carbon. By computational experiment at different values of process control parameters (the gas flow rate, the fraction of the oxidant in the gas, and the mass ratio of carbon to the inert material in the combustible mixture), it is found that, in the wave of filtration combustion of carbon under superadiabatic conditions, carbon gasification can predominately yield either CO₂ or CO.     

The challenge of conceptual modeling for product–service systems: status-quo and perspectives for reference models and modeling languages

Confronted with decreasing margins and a rising customer demand for integrated solutions, manufacturing companies integrate complementary services into their portfolio. Offering value bundles (consisting of services and physical goods) takes place in integrated product–service systems, spanning the coordinated design and delivery of services and physical goods for customers. Conceptual Modeling is an established approach to support and guide such efforts. Using a framework for the design and delivery of value bundles as an analytical lens, this study evaluates the current support of reference models and modeling languages for setting up conceptual models for an integrated design and delivery of value bundles. Consecutively, designing modeling languages and reference models to fit the requirements of conceptual models in product–service systems are presented as upcoming challenges in Service Research. To guide further research, first steps are proposed by exemplarily integrating reference models and modeling languages stemming from the service and manufacturing domains.     

Effective stiffness and microscopic deformation of an orthotropic plate containing arbitrary holes

Many engineering materials and structures, such as cellular structures, sandwich core structures and laminated plates with holes, can be modeled by an inclusion problem with anisotropic matrix. The paper studies the effective properties and the microscopic deformation of anisotropic plates with periodic holes by using direct and mathematical homogenization. The effective stiffnesses are calculated by different homogenization methods and the microscopic deformation of a RVE is modeled by the finite element method for the plate with arbitrarily shaped holes. All of the effective stiffness coefficients, especially stretching-shear coupling coefficients are evaluated.     

NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme

In glioblastoma, non-classical human leucocyte antigen E (HLA-E) and HLA-G are frequently overexpressed. HLA-E loaded with peptides derived from HLA class I and from HLA-G contributes to inhibition of natural killer (NK) cells with expression of the inhibitory receptor CD94/NKG2A. We investigated whether NK cells expressing the activating CD94/NKG2C receptor counterpart were able to exert anti-glioma effects. NKG2C+ subsets were preferentially expanded by a feeder cell line engineered to express an artificial disulfide-stabilized trimeric HLA-E ligand (HLA-E*spG). NK cells expanded by a feeder cell line, which facilitates outgrowth of conventional NKG2A+, and fresh NK cells, were included for comparison. Expansion via the HLA-E*spG feeder cells selectively increased the fraction of NKG2C+ NK cells, which displayed a higher frequency of KIR2DL2/L3/S2 and CD16 when compared to expanded NKG2A+ NK cells. NKG2C+ NK cells exhibited increased cytotoxicity against K562 and KIR:HLA-matched and -mismatched primary glioblastoma multiforme (GBM) cells when compared to NKG2A+ NK cells and corresponding fresh NK cells. Cytotoxic responses of NKG2C+ NK cells were even more pronounced when utilizing target cells engineered with HLA-E*spG. These findings support the notion that NKG2C+ NK cells have potential therapeutic value for treating gliomas.