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71.
H. M. Manukumar J. Shiva Kumar B. Chandrasekhar Sri Raghava 《Critical reviews in food science and nutrition》2017,57(12):2712-2729
Diabetes mellitus (DM) is a considerable systemic metabolic disorder to exhibit various metabolic and cardiovascular disorders, mainly hyperglycemia. The global projected estimate of diabetes in 2030 will be about 439 million adults, out of which 300 million expected are of type-2 diabetes mellitus (T2DM). The present knowledge revealed responsible factors, occurrence and mechanism of these factors involved in the DM diseases. Hence, the aim of this review is to address and summarize the causes, plant resources, importance, present status and future programmes for diabetes control. The present review answers the contemporary present questions raised in the scientific field on DM. Two major problems are explained in detail about the autoimmune attack or dysfunction of β-cell and insulin resistance involved for Type 1 and Type 2 DM, respectively. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications, many preferred herbal formulations due to lesser side effects and low cost. For this reason still it is getting increased attention in searching antidiabetic medicinal plants for hot research and to develop targeted medicine. Recurrence of islet autoimmunity lesson from pancreatic islet cell transplantation to cure T1D was outlined. With these highlights, the review summarizes the current knowledge on diabetes occurrence, factors (environmental and genetics), and types (I, II, gestation, and secondary DM), antidiabetic plants, sources for insulin mimetic plant principle compounds and their target mechanism with current and future trusted research areas for controlling of DM. 相似文献
72.
Yellela S. R. Krishnaiah Saleh M. Al-Saidan Dantam V. Chandrasekhar Bukka Rama 《Drug development and industrial pharmacy》2013,39(4):423-435
ABSTRACTThe objective of the study was to investigate the effect of nerodilol and carvone on the in vitro transdermal delivery of nicorandil so as to fabricate a membrane-moderated transdermal therapeutic system. The in vitro permeation studies were carried across the rat epidermal membrane from the hydroxypropyl methylcellulose (HPMC) gels (prepared with 70:30 v/v ethanol–water) containing selected concentrations of a terpene such as nerodilol (0% w/w, 4% w/w, 8% w/w, 10% w/w, or 12% w/w) or carvone (0% w/w, 4% w/w, 8% w/w, 12% w/w, or 16% w/w). The amount of nicorandil permeated (Q24) from HPMC gel drug reservoir without a terpene was 3424.6 ± 51.4 μg/cm2, and the corresponding flux of the drug was 145.5 ± 2.2 μg/cm2· h. The flux of nicorandil increased with an increase in terpene concentration in HPMC gel. It was increased ranging from 254.9 ± 3.1 to 375.7 ± 3.2 μg/cm2·h or 207.6 ± 4.7 to 356.7 ± 15.3 μg/cm2· h from HPMC gels containing nerodilol (4% w/w to 12% w/w) or carvone (4% w/w to 16% w/w), respectively. Nerodilol increased the flux of nicorandil by about 2.62-folds whereas carvone increased the flux of the drug by about 2.49-folds across the rat epidermal membrane. The results of the Fourier Transform Infrared (FT-IR) study indicated that the enhanced in vitro transdermal delivery of nicorandil might be due to the partial extraction of stratum corneum lipids by nerodilol or carvone. It was concluded that the terpenes, nerodilol and carvone, produced a marked penetration enhancing effect on the transdermal delivery of nicorandil that could be used in the fabrication of membrane-moderated transdermal therapeutic systems. 相似文献
73.
Polymer electrolyte membranes were prepared via the grafting of styrene and acrylic acid onto fluorinated ethylene propylene copolymer with a preirradiation technique and subsequent sulfonation. The thermal and mechanical properties of the grafted membranes and their sulfonated derivatives were dependent on the degree of grafting. The grafted membranes showed a two‐step degradation pattern, whereas their sulfonated derivatives showed a three‐step degradation pattern. The glass‐transition temperature and crystallinity percentage of the membranes were determined with differential scanning calorimetry. With an increase in the degree of grafting and sulfonation, the glass‐transition temperature increased, whereas the crystallinity percentage decreased. The tensile strength and elongation decreased with the degree of grafting and sulfonation. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 1418–1425, 2005 相似文献
74.
Piezo‐Phototronic Effect: Regulation of Charge Carrier Dynamics in ZnO Microarchitecture‐Based UV/Visible Photodetector via Photonic‐Strain Induced Effects (Small 11/2018)
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75.
A geometric approach to edge detection 总被引:2,自引:0,他引:2
This paper describes edge detection as a composition of four steps: conditioning, feature extraction, blending, and scaling. We examine the role of geometry in determining good features for edge detection and in setting parameters for functions to blend the features. We find that: (1) statistical features such as the range and standard deviation of window intensities can be as effective as more traditional features such as estimates of digital gradients; (2) blending functions that are roughly concave near the origin of feature space ran provide visually better edge images than traditional choices such as the city-block and Euclidean norms; (3) geometric considerations ran be used to specify the parameters of generalized logistic functions and Takagi-Sugeno input-output systems that yield a rich variety of edge images; and (4) understanding the geometry of the feature extraction and blending functions is the key to using models based on computational learning algorithms such as neural networks and fuzzy systems for edge detection. Edge images derived from a digitized mammogram are given to illustrate various facets of our approach 相似文献
76.
We report on our measurements of the transport properties of 0.75 m long insulating indium oxide wires and rings. These devices have no apparent tunnel barriers, yet they exhibit two properties at low temperatures which are characteristic of series arrays of small capacitance tunnel junctions: highly non-linear IV characteristics and a zero-bias conductance which is periodic in a voltage applied by means of a lateral gate. Two types of samples can be distinguished, based on the behaviour of the conductance oscillations at low temperatures. For the first type, the structure of the oscillations remains periodic down to our lowest temperatures, similar to the data from the tunnel junction arrays. For the second type, lowering the temperature results in a transition from periodic to quasi-periodic conductance peaks. A phenomelogical model based on the orthodox theory of the Coulomb blockade is able to account for most of our observations. The temperature and magnetic field dependence of these effects suggest that they are due to the influence of single electron charging on transport through the localized electron states in the indium oxide. 相似文献
77.
We investigate experimentally the performance of 42.7-Gb/s return-to-zero (RZ) differential quadrature phase-shift-keyed (DQPSK) channels in a dense wavelength-division-multiplexed transmission system having 10.7-Gb/s nonreturn-to-zero (NRZ) on-off keyed (OOK) channels. Cross-phase modulation (XPM) from the OOK channels is found to be a dominating nonlinear penalty source for copropagating DQPSK channels in a dispersion-managed transmission link with multiple standard single-mode fiber spans. It is also found that the XPM penalty strongly depends on channel occupancy and residual dispersion per span (RDPS). Large RDPS effectively mitigates XPM even for the worst-case occupancy where a 42.7-Gb/s RZ-DQPSK channel is amidst several 10.7-Gb/s NRZ-OOK channels on a 50-GHz channel grid. 相似文献
78.
Iykkiam Immanuel Selvaraj Sujatha Chaklanobis Vadapalli Chandrasekhar 《Polymer International》1998,46(2):111-116
The reaction of the sodium salt of the commercially available surfactant Igepal CA 210™ with hexachlorocyclotriphosphazene, N3P3Cl6 (1) and poly(dichlorophosphazene), [—P(Cl2)=N—]n (Publisher's note: for graphical representation please see printed journal or the Acrobat PDF version on this website.) affords lipophilic cyclo- and poly-phosphazenes SSCP (2) and SSPP (4), respectively. These materials, containing a short chain oligo etheroxy side group while being completely insoluble in water, are soluble in a wide range of solvents ranging from hexane to chloroform. The polymer, SSPP (4) forms polymer–metal salt complexes with lithium salts. DC conductivity measurements by a complex impedance method have been carried out. The maximum conductivity observed for SSPP–LiClO4 (O: Li ratio, 6:1) is 1·0×10-6Scm-1 at 348K. © 1998 SCI. 相似文献
79.
Design and implementation of wavelength-flexible network nodes 总被引:2,自引:0,他引:2
Nuzman C. Leuthold J. Ryf R. Chandrasekhar S. Giles C.R. Neilson D.T. 《Lightwave Technology, Journal of》2003,21(3):648-663
This paper analytically and experimentally examines node architectures for wavelength-routing networks, with emphasis on the degree of wavelength conversion provided. Wavelength flexibility simplifies network management and increases network capacity but requires large cross-connects and deployment of wavelength converters (WCs). A simple probabilistic model is used to upper-bound the number of WCs required at a network node, under dynamic traffic load. When provisioned in a shareable pool, with a fixed number of wavelength channels per fiber, the number of WCs required remains low as overall network capacity is scaled up. Motivated by this analysis, experiments demonstrate the feasibility of implementing wavelength-flexible network nodes using large microelectromechanical (MEMS)-based cross-connects and all-optical WCs. In one design, WCs were attached directly to cross-connect output ports, and in another, they were attached in a loop-back fashion to allow sharing. Error-free transmission at 10 Gb/s was demonstrated in both cases. 相似文献
80.
A 100% confidence interval for the steady-state availability of a system is derived, when the operating time distribution is a mixture of exponential and gamma and the repair time distribution is lognormal. It is assumed that one of the parameters of the operating time distribution and also one of the parameters of the repair time distribution are known. 相似文献