Eumelanin for nature‐inspired UV‐absorption enhancement of plastics

In the human body, the black‐brown biopigment eumelanin blocks harmful ultraviolet (UV) radiation. In the plastics industry, additives are often added to polymers to increase their UV‐absorption properties. We herein report an assessment of the biopigment eumelanin as a nature‐inspired additive for plastics to enhance their UV absorption. Since eumelanin is produced by natural sources and is nontoxic, it is an interesting candidate in the field of sustainable plastic additives. In this work, the eumelanin‐containing films of commercial ethylene–vinyl acetate copolymer, a plastic used for packaging applications, were obtained by melt compounding and compression molding. The biopigment dispersion in the films was improved by means of the melanin free acid treatment. It was observed that eumelanin amounts as low as 0.8 wt% caused an increase of the UV absorption, up to one order of magnitude in the UVA range. We also evaluated the effect of eumelanin on the thermal stability and photostability of the films: the biopigment proved to be double‐edged, working both as UV‐absorption enhancer and photo‐prooxidant, as thermogravimetric analysis and infrared spectroscopy revealed. © 2019 Society of Chemical Industry     

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single‐Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, the first single‐digit nanomolar SV2A ligands with suitable properties for development as PET tracers.     

Pregnancy outcomes are not improved by administering gonadotropin-releasing hormone at initiation of a 5-day CIDR-Cosynch resynchronization protocol for lactating dairy cows

Using a 5-d controlled internal drug-release (CIDR)-Cosynch resynchronization protocol, the objective of this study was to determine the effect of the initial GnRH injection on pregnancy per artificial insemination (P/AI) to the second artificial insemination in lactating Holstein dairy cows. On 37 ± 3 d (mean ± standard deviation) after the first artificial insemination, and upon nonpregnancy diagnosis (d 0 of the experiment), lactating cows eligible for a second artificial insemination (n = 429) were enrolled in a 5-d CIDR-Cosynch protocol. On d 0, all cows received a CIDR insert and were assigned randomly to receive the initial GnRH injection (GnRH; n = 226) of the protocol or no-GnRH (n = 203). Blood samples were collected from a sub-group of cows (n = 184) on d 0 and analyzed for progesterone (P4) concentration. On d 5, CIDR inserts were removed, and all cows received 1 injection of PGF_2α. On d 6 and 7, cows were observed once daily by employees for tail-chalk removal, and cows detected in estrus on d 6 or 7 received artificial insemination that day (EDAI), and did not receive the final GnRH injection. The remaining cows not detected in estrus by d 8 received GnRH and timed artificial insemination (TAI). Pregnancy status was confirmed by transrectal palpation of uterine contents at 37 ± 3 d (mean ± standard deviation) after the second artificial insemination. Eliminating the initial GnRH injection had no effect on P/AI compared with cows receiving GnRH (27 vs. 21%), respectively. Similarly, method of insemination (EDAI vs. TAI) and its interaction with treatment had no effect on P/AI. Primiparous cows had greater P/AI than multiparous cows (31 vs. 21%). Mean P4 concentrations (n = 184) at the initiation of the protocol did not differ between treatments (4.51 ± 0.35 ng/mL no-GnRH vs. 3.96 ± 0.34 ng/mL of GnRH). When P4 concentrations were categorized as high (≥1 ng/mL) or low (<1 ng/mL), P/AI tended to be greater for high P4 concentrations (n = 136) compared with low (n = 48) P4 concentrations (26 vs. 16%, respectively). No differences were observed in the proportion of cows with high or low P4 between treatments. Collectively, these results provide evidence that eliminating the initial GnRH in a 5-d CIDR-Cosynch resynchronization protocol for lactating dairy cows did not reduce P/AI in this study.     

Analysis of sustainable materials used in ecovillages: Review of progress in BedZED and Masdar city

This paper explores reclaimed and recycled material used in ecovillages. The models discussed in this paper include BedZED in the United Kingdom and Masdar City in the Middle East. These two communities contain features characterized by the sustainable principles of the ecovillage concept by using non-traditional building materials. The creations of more ecovillages, along with the growth of current ecovillages, play an important role in positively solvening environmental and social problems. The sustainable materials used in the ecovillages also act as a model for communities wishing to implement sustainable development.     

Robust hierarchical multiple hypothesis tracker for multiple-object tracking

Multiple object tracking is a fundamental subsystem of many higher level applications such as traffic monitoring, people counting, robotic vision and many more. This paper explains in details the methodology of building a robust hierarchical multiple hypothesis tracker for tracking multiple objects in the videos. The main novelties of our approach are anchor-based track initialization, prediction assistance for unconfirmed track and two virtual measurements for confirmed track. The system is built mainly to deal with the problems of merge, split, fragments and occlusion. The system is divided into two levels where the first level obtains the measurement input from foreground segmentation and clustered optical flow. Only K-best hypothesis and one-to-one association are considered. Two more virtual measurements are constructed to help track retention rate for the second level, which are based on predicted state and division of occluded foreground segments. Track based K-best hypothesis with multiple associations are considered for more comprehensive observation assignment. Histogram intersection testing is performed to limit the tracker bounding box expansion. Simulation results show that all our algorithms perform well in the surroundings mentioned above. Two performance metrics are used; multiple-object tracking accuracy (MOTA) and multiple-object tracking precision (MOTP). Our tracker have performed the best compared to the benchmark trackers in both performance evaluation metrics. The main weakness of our algorithms is the heavy processing requirement.     

Experimentation and the evaluation of energy efficiency programs

The use of experiments— particularly randomized controlled trials (RCTs) where subjects are randomly assigned to treatment and control conditions—has rarely been applied to the process of improving the design of energy efficiency programs and, more fundamentally, to determining the net savings from energy efficiency programs. This paper discusses the use of experimentation in the energy efficiency program field with the hope of explaining how these experiments can be used, and identifying the barriers to their use will cause more experimentation to occur. First, a brief overview of experimental methods is presented. This discussion describes the advantages and disadvantages of conducting experiments in the context of the development and evaluation of energy efficiency programs. It then discusses barriers to the use of experimental methods (including cost and equity issues) and suggests some ways of overcoming these barriers. Finally, recommendations are made for implementing key social experiments, discussing the types of energy efficiency programs and issues that can make use of experimentation and variables that one might use for selecting treatments.     

Megasonic agitation for enhanced electrodeposition of copper

In this paper we propose an agitation method based on megasonic acoustic streaming to overcome the limitations in plating rate and uniformity of the metal deposits during the electroplating process. Megasonic agitation at a frequency of 1 MHz allows the reduction of the thickness of the Nernst diffusion layer to less than 600 nm. Two applications that demonstrate the benefits of megasonic acoustic streaming are presented: the formation of uniform ultra-fine pitch flip-chip bumps and the metallisation of high aspect ratio microvias. For the latter application, a multi-physics based numerical simulation is implemented to describe the hydrodynamics introduced by the acoustic waves as they travel inside the deep microvias.     

Some microwave applications of BaSrTiO3 and high temperature superconductors

Abstract

The group at the University of Colorado has been working on the applications of BaSrTiO₃ and high temperature superconductors to microwave circuits and systems with support from Superconducting Core Technologies, NASA and ONR. This work has included the development of a voltage tunable oscillator, a phase shifter, and a voltage tunable phased array antenna system. An important aspect of this program is the lattice match between the high temperature superconductor and the ferroelectric materials which enables us to grow thin films of either material on each other. By choosing the appropriate barium stronium ratio we are able to obtain changes in the dielectric constant of 5 to 1 in bulk capacitors at 77 K, the liquid nitrogen boiling temperature. Phase shifts of a little less than 126° at 10 Ghz have been obtained by applying 5 volts on a one centimeter coplanar line. The proposed phased array systems should enable us to point the beam radiated from the antenna in an arbitrary direction using two control voltages of less than 50 volts. We believe this approach leads to the possibility of inexpensive electronically scannable antenna systems which could be used for mobile communications with satellites and cellular systems.