Effect of intrathecal nimodipine on spinal cord blood flow and evoked potentials in the normal or injured cord

A method was developed for administering intrathecal pharmacotherapy in a rat model of spinal cord injury. The effects of intrathecal administration of nimodipine on spinal cord blood flow (SCBF) and evoked potentials (EPs) were measured in the normal and injured spinal cord. It had previously been shown that systemic nimodipine caused severe hypotension after spinal cord injury. After baseline SCBF and EPs, 15 uninjured rats were blindly allocated to one of three groups: one placebo group (n = 5); and two groups with intrathecal nimodipine, 0.05 mg/kg (n = 5), or 0.2 mg/kg (n = 5). Ten other rats received a 35 g acute clip compression injury of the spinal cord for 1 minute and, were allocated to one of two groups: placebo (n = 5); and intrathecal nimodipine 0.05 mg/kg (n = 5) given 60 min after injury. In the uninjured groups, neither 0.05 nor 0.2 mg/kg of nimodipine increased SCBF during, or 30 min after, intrathecal infusion. However, the mean arterial blood pressure (MABP) decreased significantly to 69.73.1% after the infusion of 0.2 mg/kg nimodipine and did not recover by 98 min. In all three groups of uninjured rats, the amplitude of the cerebellar EP was decreased 30 min after infusion. After spinal cord injury, there were significant decreases in MABP, SCBF and EP amplitude in both placebo and treatment groups, but there was no therapeutic benefit from nimodipine. Thus, intrathecal infusion of nimodipine did not prevent the hypotension encountered with systemic administration and exerted no beneficial effect on SCBF or EPs after acute spinal cord injury.     

An anthropocentric approach to knowledge-based preventive maintenance

It is common knowledge today that application of sound manufacturing concepts and techniques will only provide cost-effective, long-term return when manufacturing functions are totally integrated with the operators, maintenance engineers and other associated personnel. This paper presents a human-centred methodology and its associated knowledge-based tool, to utilize equipment failure information for the purpose of machine down-time minimization. Based upon a structured and rigorous assessment of each breakdown, and combined with total employee participation, continuous improvement of maintenance function and operational effectiveness of equipment can be made a reality.     

实施六大工程打造民生水利

我省针对十年九旱、水资源短缺、生态与环境脆弱的特点，确定了今冬明春农田水利基本建设的目标任务，明确以实施兴水战略为主线，以改善民生为目标，以创新机制为保障，全面掀起冬春农田水利基本建设新高潮。     

紧急停车系统在鼓风机自保逻辑上的应用

介绍了西门子 PLC逻辑控制程序在主风机自保上的应用,以及在两段提升管催化裂化装置上所用紧急停车系统(ESD)的软硬件配置.     

宣钢1260 m3高炉扩容大修改造设计

宣钢l260m^3高炉大修改造时将炉容扩大到l350m^3，对高炉本体系统设备及冷却系统、自动控制及检测系统进行了全面的改造更新，在炉腹、炉腰及炉身下部高热负荷区域采用铜冷却壁，取消炉身中上部铸铁冷却壁凸台，并采用薄内衬等先进、适用、可靠、成熟的技术。     

易逝品联合采购订货决策分析

采购联盟成员间的信息不完全,彼此均以对方的期望需求作为对方实际需求的估计.针对易逝品的特点,提出了调剂价格的特殊约束条件并建立了联盟期望利润模型,最后进行了数值仿真.研究表明:联合采购使联盟总体利润得到改善,但不能使联盟成员的利润都得到改善.     

屏蔽电泵运行中存在问题的分析与改进

对屏蔽电泵在非设计流量下工作存在较大的轴向力不平衡，造成前端轴承磨损严重进行了分析。在不降低效率的情况下，在屏蔽电泵的泵头加入平衡盘使轴向力得到平衡，并取得了满意的效果。     

坨五站中间乳化层快速增长原因及治理方案

胜利采油厂坨五站高含水(95％)原油化学预脱水中，二级沉降罐内油水相之间的中间乳化层增长迅速，引起了一系列问题。现场调查和大量室内测试结果表明，产生这一现象的原因有：油溶性破乳剂WD-1加入点不合理。有2／3的含水原油在通过油水分离器之后才与破乳剂混合；二级沉降罐进油口伸入油相内，油流的冲击达不到中间层；WD-1对坨五站混合原油中的稠油破乳脱水性能欠佳，不能适应坨五站混合原油组成和含水的变化。针对上述各种原因筛选出了性能更好的一种破乳剂1916。根据确定的几种原因采取了相应的措施：将破乳剂加入点改在3个并联油水分离器之前；将二级沉降罐的进油口移到水相内；改用筛选出的破乳剂1916，结果使中间乳化层的增长受到了抑制。图2表4参2。     

Study on Adsorption Behavior of Rare Earth Complexes on Nanometer-Size Titanium Dioxide with ICP-AES

Inrecentyears ,rareearthelements (REEs)havebeenwidelyusedinfunctionalmaterials ,cata lystsandotherproductsinindustry ,diagnosisreagentsofmagneticresonanceimaging (MRI)inmedicineandsomefertilizersinagricultureespeciallyinChina .However,asaresultoftheirusage ,moreandmoreREEsaregettingintotheenvironment,andalsointohumanbodyviafoodchain[1,2 ] .Itisnotclearwhetherrareearthelementsareessentialforman ,soitisveryurgenttostudythebiologicaleffectofrareearthelementsinhumanhealthandenvironment .Inthes…