合肥电视塔TMD风振控制的响应分析

本文进行了合肥电视塔风振响应分析,探讨了电视塔人体舒适度设计准则。计算表明,电视塔上塔楼的加速度响应大大超出了容许的最大加速度限值。因此,利用塔上60t重的生活、消防用水箱作为调频质量阻尼器(TMD)。通过在频域内大量的TMD参数研究,确定TMD的优化参数。研究结果表明,具有最优参数TMD可以显著提高电视塔的人体舒适度性能,上塔楼的加速度响应下降了49%。在此基础上,本文提出了TMD优化参数的选择路线,结合受控和未控结构的响应比与频率比和TMD阻尼比的关系曲线,采用图解法确定了满足减振要求的TMD优化参数。     

The fracture behaviour of structural adhesives under high rates of testing

Structural adhesive joints were subjected to high loading rates in mode I and their resulting fracture behaviour was studied in detail. Joints were formed between unidirectional carbon-fibre epoxy composites and between aluminium alloy substrates bonded with a tough, single-part automotive adhesive (XD4600) from Dow Automotive. Double cantilever beam (DCB) and tapered double cantilever beam (TDCB) tests were performed, from quasi-static loading rates up to 15 m/s, and a test rig was developed incorporating high-speed video acquisition for the high-speed tests. A detailed data reduction strategy was developed to account for (i) the types of different fracture behaviour regimes encountered, (ii) the dynamic effects in the test data, and (iii) the contribution of kinetic energy in the specimen arms to the energy balance. Using the above data reduction strategy, increasing the test rate over six decades (from 10⁻⁵ to 10¹ m/s) was found to lead to a reduction in the value of the adhesive fracture energy, G_Ic, by about 40% of its quasi-static value, i.e. from 3.5 to about 2.2 kJ/m². Further, at quasi-static loading rates, the measured adhesive fracture energies were independent of substrate material and test geometry (i.e. DCB or TDCB). However, at faster loading rates, the TDCB tests induced higher crack velocities for a given loading rate compared with the DCB test geometry, and neither the test rate nor the crack velocity were found to be the parameter controlling the variation in G_Ic with increased test rate. Thus, an isothermal–adiabatic model was developed and it was demonstrated that such a model could unify the DCB and TDCB test results. Indeed, when the G_Ic values were plotted as a function of 1/√time, where the time was defined to be from the onset of loading the material to that required for the initiation of crack growth, the results collapsed onto a single master curve, in agreement with the isothermal–adiabatic model.     

Single‐Step Deposition of Au‐ and Pt‐Nanoparticle‐Functionalized Tungsten Oxide Nanoneedles Synthesized Via Aerosol‐Assisted CVD,and Used for Fabrication of Selective Gas Microsensor Arrays

Tungsten oxide nanostructures functionalized with gold or platinum NPs are synthesized and integrated, using a single‐step method via aerosol‐assisted chemical vapour deposition, onto micro‐electromechanical system (MEMS)‐based gas‐sensor platforms. This co‐deposition method is demonstrated to be an effective route to incorporate metal nanoparticles (NP) or combinations of metal NPs into nanostructured materials, resulting in an attractive way of tuning functionality in metal oxides (MOX). The results show variations in electronic and sensing properties of tungsten oxide according to the metal NPs introduced, which are used to discriminate effectively analytes (C₂H₅OH, H₂, and CO) that are present in proton‐exchange fuel cells. Improved sensing characteristics, in particular to H₂, are observed at 250 °C with Pt‐functionalized tungsten oxide films, whereas non‐functionalized tungsten oxide films show responses to low concentrations of CO at low temperatures. Differences in the sensing characteristics of these films are attributed to the different reactivities of metal NPs (Au and Pt), and to the degree of electronic interaction at the MOX/metal NP interface. The method presented in this work has advantages over other methods of integrating nanomaterials and devices, of having fewer processing steps, relatively low processing temperature, and no requirement for substrate pre‐treatment.     

基于频域系统辨识和支持向量机的桥梁状态监测方法

随着大跨度悬索、斜拉桥的增加,保障桥梁安全、降低维护费用成为交通管理以及政府部门关注的问题。针对损伤样本难以获得的实际情况,将桥梁状态监测问题作为模式识别中的“一类学习”问题处理。桥梁模式特征获取过程是“只有输出响应”的系统辨识问题,考虑到监测系统需要在线工作的特点,提出运用概念直观、结果可靠且便于自动实现的CMIF系统辨识方法作为获取模式特征的工具。为了获得足够敏感的异常报警判别函数,采用了基于支持向量机的一类学习算法,这种方法在得到很高灵敏性的同时,可以方便地权衡敏感性和泛化性能之间的矛盾。用香港汀九桥794小时实测数据对所采用的算法进行验证,证明了算法的有效性和实用性,其结果可供设计类似监测系统时参考。     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.     

Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A

This study characterized the antinociceptive, respiratory and heart rate effects of the cannabinoid receptor agonists Delta-9-tetrahydrocannabinol (Delta-9-THC) and WIN 55212 ((R)-(+)-2, 3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol-[1,2,3-de]-1, 4-benzoxazin-6-yl)(1-naphtalenyl)methanone monomethanesulfonate), N-arachidonyl ethanolamide (anandamide) and the mu and kappa opioid receptor agonists heroin and U69593, alone and in conjunction with a cannabinoid receptor antagonist, SR 141716A [N-(piperidin-1-1-yl)-5-(4-chlorophenyl)-1(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride] and an opioid receptor antagonist, quadazocine, in rhesus monkeys (Macaca mulatta). Using 12 adult rhesus monkeys, latencies to remove the tail from a 50 degrees C water bath, respiration in 5% CO2 and heart rate were measured. When administered alone, SR 141716A (1.8, 5.6 mg/kg i.m.) did not alter nociception, respiration or heart rate. Delta-9-THC (0.1-10 mg/kg i.m.) and WIN 55212 (0.1-10 mg/kg i.m.) dose-dependently increased antinociception and dose-dependently decreased respiratory minute and tidal volumes and heart rate. These antinociceptive, respiratory and heart rate effects were reversed by SR 141716A but not by the opioid antagonist quadazocine (1 mg/kg i.m.). Anandamide (10 mg/kg i.m.) also produced antinociception. Heroin (0.01-10 mg/kg i.m.) and U69593 (0.01-3.2 mg/kg i.m.) also dose-dependently increased antinociception and decreased respiratory and heart rate measures; these effects were antagonized by quadazocine but not by SR 141716A. These results demonstrate selective and reversible antagonism of cannabinoid behavioral effects by SR 141716A in rhesus monkeys.