The role of dispositional and situational antecedents in prosocial organizational behavior: An examination of the intended beneficiaries of prosocial behavior.

Research has not adequately separated the factors responsible for prosocial behaviors intended to benefit specific individuals from those intended to benefit an organization. Antecedents of the behavior of 100 secretaries were examined as a function of the beneficiary of the behavior. The value of concern for others and empathy explained significant variance in prosocial behaviors directed only at specific individuals (prosocial individual behavior). Perceptions of reward equity and recognition explained significant variance in behaviors directed only at the organization (prosocial organizational behavior). With these effects removed, the relationship between job satisfaction and prosocial organizational behavior was no longer significant, whereas the relationship between job satisfaction and prosocial individual behavior remained significant. Results suggest that the psychological processes that underlie prosocial behavior are different depending on the beneficiary of the behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Antidepressant pharmacotherapy helps some cigarette smokers more than others.

Adult smokers (N?=?253) without clinically significant depression were randomized on a double-blind basis to receive fluoxetine (30 or 60 mg daily) or a placebo for 10 weeks in combination with cognitive-behavioral therapy (CBT). It was predicted that fluoxetine would selectively benefit smokers with higher baseline depression, nicotine dependence, and weight concern and lower self-efficacy about quitting smoking. Among those who completed the prescribed treatment regimen, baseline depression scores moderated the treatment response. Logistic regression analyses showed that 1 and 3 months after the quit date, fluoxetine increased the likelihood of abstinence, as compared with placebo, among smokers with minor depression but not among those with little or no depression. Results suggest that, as an adjunct to CBT, fluoxetine enhances cessation by selectively benefiting medication-compliant smokers who display even subclinical levels of depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview,Technical Development,and Measures of Peripheral Activation in Adolescent Patients

The NOD-, LRR-, and pyrin-domain-containing protein 3 (NLRP3) inflammasome is a node of intracellular stress pathways and a druggable target which integrates mitochondrial stress and inflammatory cascades. While a body of evidence suggests the involvement of the NLRP3 inflammasome in numerous diseases, a lack of reliable measurement techniques highlights the need for a robust assay using small quantities of biological samples. We present a literature overview on peripheral activation of the NLRP3 inflammasome in mood disorders, then outline a process to develop and validate a robust assay to measure baseline and activated intracellular levels of “apoptosis-associated speck-like protein containing a CARD” (ASC) as a key component of an inflammatory profile in peripheral blood mononuclear cells (PBMC). A consistent association between high NLRP3 mRNA levels and relevant cytokines was seen in the literature. Using our method to measure ASC, stimulation of PBMC with lipopolysaccharide and nigericin or adenosine triphosphate resulted in microscopic identification of intracellular ASC specks, as well as interleukin 1 (IL-1) beta and caspase-1 p10 in the periphery. This was abolished by dose-dependent pre-treatment with 100 nM MCC950. We also report the use of this technique in a small pilot sample from patients with bipolar disorder and depressive disorders. The results show that levels of intracellular ASC and IL-1 beta are sensitive to change upon activation and maintained over time, which may be used to improve the detection of NLRP3 activation and guide personalized therapeutic strategy in the treatment of patients.     

The effects of a group decision support system on culturally diverse and culturally homogeneous group decision making

Considerable research has been conducted over the last decade on the effects of using Group Decision Support Systems (GDSS) in group decision making. Studies have examined the influence of GDSS on such variables as group task, size, quality of decision, and satisfaction with the process. However, only a few studies have focused on the use of GDSS and its interaction with group composition. This study compared the effects of group decision making, both with and without GDSS technology, on culturally diverse and homogeneous groups. Group performance was measured by the number of non-redundant, realistic ideas and the quality of solution produced in response to posed problems. The GDSS used in the study was Vision Quest. Groups using it, regardless of cultural make up, developed a significantly higher number of non-redundant, realistic ideas than groups that did not. Furthermore, among groups using the GDSS, culturally diverse groups produced a significantly higher number of non-redundant, realistic ideas than homogeneous groups that used the GDSS. Implications for diversity management and group support research are suggested.     

Fast Distributed Network Decompositions and Covers

This paper presents deterministic sublinear-time distributed algorithms for network decomposition and for constructing a sparse neighborhood cover of a network. The latter construction leads to improved distributed preprocessing time for a number of distributed algorithms, including all-pairs shortest paths computation, load balancing, broadcast, and bandwidth management.     

A GC–MSD method for analysis of dimethyl sulfate in palm oil-based esterquat

Dimethyl sulfate (DMS) is a quarternizing agent for esteramine used for the synthesis of esterquat. To date there is no reliable published method for quantification of DMS in palm-based esterquat. Esterquat is used in the formulation of personal care and textile cleaning. The process of quaternization is usually incomplete and there will be unreacted DMS. This work presents a new simple method involving solvent extraction of DMS followed by analysis with gas chromatography–mass spectrometry detector to quantify the unreacted DMS. This method was validated as per International Council for Harmonization requirements. This novel method showed good repeatability (relative standard deviation [RSD] < 5%) and inter-day with different analyst reproducibility (RSD < 5%). The limits of detection and quantification were 5 and 10 μg mL⁻¹, respectively. The accuracy of the method was evaluated by the analysis of spiked samples and it was found that good recovery was found at spiking levels of 20, 30, and 50 μg mL⁻¹ with % recovery falling within the 80%–120% acceptable limit. However, at 10 μg mL⁻¹, the percentage recovery was slightly below the recommended limit.     

Embracing brain and behaviour: Designing programs of complementary neurophysiological and behavioural studies

NeuroIS—the methods and knowledge of neuroscience applied to the information systems (IS) domain—has become an established research field within the IS discipline. A key advantage of NeuroIS is its ability to provide insights into human cognition beyond those obtained using behavioural techniques alone. Nevertheless, in neuroscience, there is renewed interest in examining behaviour together with neurophysiological methods to better inform our understanding of neural processes. In this research opinion article, we argue that in the field of NeuroIS, there is an opportunity for hybrid programs of study that combine neurophysiological and behavioural methods in a complementary manner. We outline four strategies for designing complementary neurophysiological and behavioural experiments in a research program: (1) observe the relationship between neural processes and behavioural change; (2) combine neurophysiological and behavioural methods to enhance internal, external, and ecological validity; (3) extend, rather than replicate, experiments based on theory; and (4) use neurophysiological and behavioural experiments together to evaluate IT artefact design. By applying these strategies, researchers can more effectively design programs using complementary neurophysiological and behavioural methods, which, in turn, can help to provide richer insights into the phenomena under study as well as accelerate the advancement of IS knowledge.     

Transesterification of Palm-based Methyl Palmitate into Esteramine Catalyzed by Calcium Oxide Catalyst

The technology for transesterification reactions between methyl esters and alcohols is well established by using classical homogeneous alkaline catalysts, which provide high conversion of methyl esters to specialty or nonindigenous esters. However, in certain products where the purity of the esters is of concern, the removal of homogeneous catalysts after the completion of the reaction is a challenge in terms of production cost and water footprint. Therefore, a study to investigate the potential of heterogeneous catalysts was conducted on reactions between methyl palmitate and triethanolamine. The degree of basicity and active surface area of calcium oxide (CaO), zinc oxide (ZnO), and magnesium oxide (MgO) were first characterized by using temperature-programmed desorption (TPD-CO₂) and Brunauere–Emmett–Teller (BET), respectively. Among the metal oxides investigated, the CaO catalyst showed the best catalytic activity toward the transesterification process as it gave the highest conversion of methyl palmitate and yielded fatty esteramine compositions similar to the conventional homogeneous catalyst. The optimum transesterification condition by using the CaO catalyst utilized a lower vacuum system of approximately 200 mbar, which could minimize a considerable amount of energy consumption. Furthermore, low CaO dosage of 0.1% was able to give a conversion of 94.5% methyl ester and formed esteramine at 170 °C for 2 h. Therefore, the production of esterquats from esteramine may become more economically feasible through the methyl ester route by using the CaO catalyst, which can be recycled three times.