全文获取类型
收费全文 | 360篇 |
免费 | 52篇 |
专业分类
化学工业 | 124篇 |
金属工艺 | 8篇 |
机械仪表 | 17篇 |
建筑科学 | 7篇 |
能源动力 | 10篇 |
轻工业 | 140篇 |
水利工程 | 4篇 |
石油天然气 | 1篇 |
无线电 | 9篇 |
一般工业技术 | 47篇 |
冶金工业 | 11篇 |
原子能技术 | 3篇 |
自动化技术 | 31篇 |
出版年
2024年 | 4篇 |
2023年 | 5篇 |
2022年 | 20篇 |
2021年 | 41篇 |
2020年 | 24篇 |
2019年 | 25篇 |
2018年 | 25篇 |
2017年 | 44篇 |
2016年 | 24篇 |
2015年 | 11篇 |
2014年 | 15篇 |
2013年 | 36篇 |
2012年 | 24篇 |
2011年 | 25篇 |
2010年 | 8篇 |
2009年 | 10篇 |
2008年 | 14篇 |
2007年 | 10篇 |
2006年 | 8篇 |
2005年 | 8篇 |
2004年 | 5篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 1篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 5篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有412条查询结果,搜索用时 390 毫秒
61.
Bianca Cristina Nogueira Fernandes Bruna Barbon Paulo Maria Clara Guimarães Claire Isabel Grigoli de Luca Sarantopoulos Nathália Ramos de Melo Ana Silvia Prata 《Comprehensive Reviews in Food Science and Food Safety》2022,21(3):2309-2334
Food safety and extended shelf life linked to convenience were the major reasons for the development of the packaging field. However, advances in material science and the widespread encapsulation technologies are allowing the establishment of new concepts for packages, such as intelligent and active packages. Particulate systems have been developed in recent years for the most diverse area with several purposes that can be employed to improve packaging performance mainly focusing on the modification of barrier properties. This review analyzes the recent developments using encapsulation in food packaging and the main concepts about mass transfer evolved in the functionality of these packages, as well as discusses the research challenges faced by the food packaging sector. 相似文献
62.
Leda Cristina Muzzi Cunha Maria Lúcia Guerra Monteiro Bruno Reis Carneiro da Costa-Lima Juliana Maria Guedes-Oliveira Bruna Leal Rodrigues Alice Raquel Fortunato Jéssica Diogo Baltar Renata Valeriano Tonon Tatiana Koutchma Carlos Adam Conte-Junior 《Journal of Food Processing and Preservation》2021,45(3):e15272
63.
Bruna Panizzutti Chiara C. Bortolasci Briana Spolding Srisaiyini Kidnapillai Timothy Connor Mark F. Richardson Trang T. T. Truong Zoe S. J. Liu Gerwyn Morris Laura Gray Jee Hyun Kim Olivia M. Dean Michael Berk Ken Walder 《International journal of molecular sciences》2021,22(13)
Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar disorder (BD), and the Hippo pathway is known to interact with multiple other signaling pathways previously associated with BD and other psychiatric disorders. In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h. Genome-wide mRNA expression was quantified and analyzed using gene set enrichment analysis (GSEA), with genes belonging to Hippo, Wnt, Notch, TGF- β, and Hedgehog retrieved from the KEGG database. Five of the eight drugs downregulated the genes of the Hippo pathway and modulated several genes involved in the interacting pathways. We speculate that the regulation of these genes, especially by aripiprazole, clozapine, and quetiapine, results in a reduction of MAPK and NFκB pro-inflammatory signaling through modulation of Hippo, Wnt, and TGF-β pathways. We also employed connectivity map analysis to identify compounds that act on these pathways in a similar manner to the known psychiatric drugs. Thirty-six compounds were identified. The presence of antidepressants and antipsychotics validates our approach and reveals possible new targets for drug repurposing. 相似文献
64.
The relationships between changes in energy metabolism and the antioxidant defense system in the weed species Ipomoea triloba L. during seed germination and early seedling growth were investigated. The effects of some common allelochemicals on these
parameters also were studied. Respiratory activity and the activities of alcohol dehydrogenase, superoxide dismutase, catalase,
guaicol peroxidase, ascorbate peroxidase, glutathione reductase, and lipoxygenase were measured. Mitochondrial oxidative phosphorylation
resumed shortly after the seed imbibition period, as indicated by considerable KCN-sensitive respiratory activity in embryos
of I. triloba. The occurrence of superoxide dismutase, catalase, guaicol peroxidase, and lipoxygenase activities in the embryos, along
with significant KCN-insensitive respiration, suggest that production of reactive oxygen species (ROS) is initiated as soon
as mitochondrial respiration is resumed. All assayed antioxidant enzymes were present in the embryos except ascorbate peroxidase,
which appeared only in primary roots. The activities of antioxidant enzymes increased after completion of germination, especially
in primary roots. Superoxide dismutase, catalase, and guaicol peroxidase probably were the crucial enzymes involved in the
neutralization of ROS, since they had higher levels of activity compared with other enzymes, such as ascorbate peroxidase
and glutathione reductase. When seeds were grown in the presence of α-pinene, coumarin, quercetin, and ferulic acid, there
was an additional increase in activities of antioxidant enzymes, as well as increases in lipoxygenase activity and KCN-insensitive
respiration, suggesting a further increase in ROS generation. The antioxidant defense system of I. triloba was not effective in preventing lipid peroxidation caused by α-pinene. The data indicate that during seed germination and
initial growth of I. triloba, a period when antioxidant enzyme activity increases to counteract the harmful ROS effects produced during mitochondrial
metabolism resumption, the presence of allelochemicals, which cause further oxidative stress, may leave the seeds/seedlings
more vulnerable to cellular dysfunction and cell death. 相似文献
65.
Kumari Sonal Choudhary Sanjarbek Hudaiberdiev Zsolt Gelencsér Bruna Gon?alves Coutinho Vittorio Venturi Sándor Pongor 《International journal of molecular sciences》2013,14(7):13727-13747
Members of the Burkholderia genus of Proteobacteria are capable of living freely in the environment and can also colonize human, animal and plant hosts. Certain members are considered to be clinically important from both medical and veterinary perspectives and furthermore may be important modulators of the rhizosphere. Quorum sensing via N-acyl homoserine lactone signals (AHL QS) is present in almost all Burkholderia species and is thought to play important roles in lifestyle changes such as colonization and niche invasion. Here we present a census of AHL QS genes retrieved from public databases and indicate that the local arrangement (topology) of QS genes, their location within chromosomes and their gene neighborhoods show characteristic patterns that differ between the known Burkholderia clades. In sequence phylogenies, AHL QS genes seem to cluster according to the local gene topology rather than according to the species, which suggests that the basic topology types were present prior to the appearance of current Burkholderia species. The data are available at http://net.icgeb.org/burkholderia/. 相似文献
66.
Taiana M. Deboni Maitê S. Cuevas Paulo Mielke Neto Rafael V. Mota Fabiolla S. Damasceno Luiza Helena Meller da Silva Christianne E. C. Rodrigues Antonio J. A. Meirelles 《Food and Bioprocess Technology》2013,6(12):3335-3344
This work investigated the deacidification of soybean oil by ion exchange using a fixed bed loaded with the strong anionic resin Amberlyst A26 OH. Degummed soybean oil was dissolved in isopropanol and the deacidification process was studied according to an experimental design based on two factors, the feed flow rate and its content of free fatty acids. The responses of interest were the solute recovery efficiency and the bed utilization efficiency, both calculated from breakthrough curves. Oil samples before and after deacidification by ion exchange, as well as samples deacidified in the industrial plant by the chemical method, were characterized according to the usual indexes for quality and identity. The results revealed that the flow rate was an important and statistically significant factor with 95 % of confidence. The deacidification by ion exchange decreased the oil acidity and also removed undesirable compounds, such as phospholipids and peroxides. However, a decrease in the concentration of tocopherol was also observed. 相似文献
67.
Bruna N. Teixeira Necla Ozdemir Laura E. Hill Carmen L. Gomes 《Journal of food science》2013,78(12):N1913-N1920
Previous studies have reported antimicrobial and antioxidant activity of black pepper oleoresin which is associated to its phenolic compounds and piperine. The ability of cyclodextrins to form an inclusion complex with a guest molecule could improve black pepper oleoresin application, bioavailability, and stability in foods. Hydroxypropyl beta‐cyclodextrin (HPBCD) inclusion complex with black pepper olereosin were synthesized using the kneading method and characterized for its physico‐chemical properties and its antioxidant and antimicrobial activities. Inclusion complex size was 103.9 ± 7.6 nm and indicated to be a polydisperse system. The entrapment efficiency was 78.3 ± 3.6%, which suggests that other constituents in black pepper oleoresin have higher affinities for HPBCD than piperine (major compound in black pepper oleoresin). Thermograms showed the disappearance of oxidation peaks of black pepper oleoresin, proving complex formation with HPBCD. Phase solubility results indicated 1:1 stoichiometric inclusion complex formation and an increase of black pepper oleoresin aqueous solubility with HPBCD concentration. Nano‐encapsulation with HPBCD did not affect (P > 0.05) total phenolic content; however, it enhanced (P < 0.05) black pepper oleoresin antioxidant activity. Black pepper oleoresin and its inclusion complex were analyzed for their antimicrobial activity against Escherichia coli K12 and Salmonella enterica serovar Typhimurium LT2. Both free and encapsulated black pepper oleoresin effectively inhibited bacterial growth within the concentration range tested. Black pepper oleoresin encapsulated in HPBCD was able to inhibit Salmonella at lower (P < 0.05) concentrations than its corresponding free extract. Therefore, black pepper oleoresin‐HPBCD nanocapsules could have important applications in the food industry as antimicrobial and antioxidant system. 相似文献
68.
J.M. Bruna M. Fernández E.M. Hierro J.A. Ordóntez L. de la Hoz 《Journal of food science》2000,65(4):731-738
ABSTRACT: The effect of inoculation of the "salchichón" (dry fermented sausage) surface with an atoxigenic, proteolytic, and lipolytic strain of Mucor racemosus and/or the addition of a intracellular extract of the same mold on the ripening process was studied. Four batches of salchichón were manufactured: control, superficially inoculated, added with intracellular extract, and a combination of both treatments. Superficial mold modified the amino and free fatty acid contents, volatile compounds, and sensory properties. Intracellular extract degraded free amino acids, producing a rise in ammonia and volatile compounds. Both treatments combined improved significantly the sensory properties, which were given scores higher than control sausages at the end of ripening. 相似文献
69.
Jordão CP Fernandes RB de Lima Ribeiro K de Souza Nascimento B de Barros PM 《Journal of hazardous materials》2009,162(2-3):804-811
The adsorption of Zn(II) from both synthetic solution and kaolin industry wastewater by cattle manure vermicompost was studied. The adsorption process was dependent on the various operating variables, viz., solution pH, particle size of the vermicompost, mass of vermicompost/volume of the Zn(II) solution ratio, contact time and temperature. The optimum conditions for Zn adsorption were pH 6.0, particle size of < or = 250 microm, 1 g per 10 mL adsorbent dose, contact time of 4h and temperature of 25 degrees C. Langmuir and Freundlich adsorption isotherms fit well in the experimental data and their constants were evaluated, with R(2) values from 0.95 to 0.99. In synthetic solution, the maximum adsorption capacity of the vermicompost for Zn(2+) ions was 20.48 mg g(-1) at 25 degrees C when the vermicompost dose was 1 g 10 mL(-1) and the initial adjusted pH was 2. The batch adsorption studies of Zn(II) on vermicompost using kaolin wastewater have shown the maximum adsorption capacity was 2.49 mg g(-1) at pH 2 (natural pH of the wastewater). The small values of the constant related to the energy of adsorption (from 0.07 to 0.163 L mg(-1)) indicated that Zn(2+) ions were binded strongly to vermicompost. The values of the separation factor, R(L), which has been used to predict affinity between adsorbate and adsorbent were between 0 and 1, indicating that sorption was very favorable for Zn(II) in synthetic solution and kaolin wastewater. The thermodynamic parameter, the Gibbs free energy, was calculated for each system and the negative values obtained confirm that the adsorption processes are spontaneous. The DeltaG degrees values were -19.656 kJ mol(-1) and -16.849 kJ mol(-1) for Zn(II) adsorption on vermicompost in synthetic solution at pH 6 and 2, respectively, and -13.275 kJ mol(-1) in kaolin wastewater at pH 2. 相似文献
70.
Leonardo Oliveira Bittencourt Victria Santos Chemelo Walessa Alana Bragana Arago Bruna Puty Aline Dionizio Francisco Bruno Teixeira Mileni Silva Fernandes Mrcia Cristina Freitas Silva Luanna Melo Pereira Fernandes Edivaldo Herculano Corrêa de Oliveira Marilia Afonso Rabelo Buzalaf Maria Elena Crespo-Lopez Cristiane do Socorro Ferraz Maia Rafael Rodrigues Lima 《International journal of molecular sciences》2022,23(1)
Mercury is a severe environmental pollutant with neurotoxic effects, especially when exposed for long periods. Although there are several evidences regarding mercury toxicity, little is known about inorganic mercury (IHg) species and cerebellum, one of the main targets of mercury associated with the neurological symptomatology of mercurial poisoning. Besides that, the global proteomic profile assessment is a valuable tool to screen possible biomarkers and elucidate molecular targets of mercury neurotoxicity; however, the literature is still scarce. Thus, this study aimed to investigate the effects of long-term exposure to IHg in adult rats’ cerebellum and explore the modulation of the cerebellar proteome associated with biochemical and functional outcomes, providing evidence, in a translational perspective, of new mercury toxicity targets and possible biomarkers. Fifty-four adult rats were exposed to 0.375 mg/kg of HgCl2 or distilled water for 45 days using intragastric gavage. Then, the motor functions were evaluated by rotarod and inclined plane. The cerebellum was collected to quantify mercury levels, to assess the antioxidant activity against peroxyl radicals (ACAPs), the lipid peroxidation (LPO), the proteomic profile, the cell death nature by cytotoxicity and apoptosis, and the Purkinje cells density. The IHg exposure increased mercury levels in the cerebellum, reducing ACAP and increasing LPO. The proteomic approach revealed a total 419 proteins with different statuses of regulation, associated with different biological processes, such as synaptic signaling, energy metabolism and nervous system development, e.g., all these molecular changes are associated with increased cytotoxicity and apoptosis, with a neurodegenerative pattern on Purkinje cells layer and poor motor coordination and balance. In conclusion, all these findings feature a neurodegenerative process triggered by IHg in the cerebellum that culminated into motor functions deficits, which are associated with several molecular features and may be related to the clinical outcomes of people exposed to the toxicant. 相似文献