Closed-Form Solutions for the Transient and Steady-State Temperature of a Lumped Mass Coupled to Linear and Radiant Boundaries

Exact closed-form solutions describing the transient and steady-state temperature of a lumped mass, linearly coupled to a fixed-temperature boundary and radiatively coupled to a second fixed-temperature boundary, with a constant impressed heat load, are derived. The results are verified by evaluation of limiting cases and comparison with commercial finite-difference heat transfer software.     

Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding

Herpes simplex virus (HSV)-2 is periodically shed in the human genital tract, most often asymptomatically, and most sexual transmissions occur during asymptomatic shedding. It would be helpful to identify a genital viral load threshold necessary for transmission, as clinical interventions that maintain viral quantity below this level would be of high utility. However, because viral expansion, decay and re-expansion kinetics are extremely rapid during shedding episodes, it is impossible to directly measure genital viral load at the time of sexual activity. We developed a mathematical model based on reproducing shedding patterns in transmitting partners, and median number of sex acts prior to transmission in discordant couples, to estimate infectivity of single viral particles in the negative partner''s genital tract. We then inferred probability estimates for transmission at different levels of genital tract viral load in the transmitting partner. We predict that transmission is unlikely at viral loads less than 10⁴ HSV DNA copies. Moreover, most transmissions occur during prolonged episodes with high viral copy numbers. Many shedding episodes that result in transmission do not reach the threshold of clinical detection, because the ulcer remains very small, highlighting one reason why HSV-2 spreads so effectively within populations.     

Drawing in Time: Processes of Design and Fabrication

Drawing embeds time within itself, notating changes in space and duration. For Babak Bryan and Henry Grosman , founding partners of BanG studio in Long Island City, New York: ‘The drawing is a result of process, but it also describes process.’ It is only through this temporal practice that an essential connection is developed between drawing and building. With the widespread adoption of building information modelling (BIM), linear graphic representation finds itself in crisis, challenged by the static inertia of the model. As Bryan and Grosman describe, the well-crafted drawing remains essential to their studio's approach informing the method of ‘making and remaking’.     

Cities under Siege: Urban Planning and the Threat of Infectious Disease

Many analysts argue that the potential for a natural, accidental, or nefarious infectious disease event to have a dramatic impact on urban areas in the United States and abroad is growing. After reviewing the justification for this position, this article considers what cities should do to prepare for a major disease event. Recognizing that prevention and preparation receive insufficient attention, we recommend that planners seek out and work with both public and private sector groups with roles in disaster planning; design land and transportation planning information systems to aid and support decision makers during crises; encourage greater self-sufficiency in food production and consumption; assist in the design of humane, realistic evacuation strategies and routes; and consider the effects of their day-to-day recommendations on disease risk and response.     

Acute β-Hydroxy-β-Methyl Butyrate Suppresses Regulators of Mitochondrial Biogenesis and Lipid Oxidation While Increasing Lipid Content in Myotubes

Leucine modulates synthetic and degradative pathways in muscle, possibly providing metabolic benefits for both athletes and diseased populations. Leucine has become popular among athletes for improving performance and body composition, however little is known about the metabolic effects of the commonly consumed leucine‐derived metabolite β‐hydroxy‐β‐methyl butyrate (HMB). Our work measured the effects of HMB on metabolic protein expression, mitochondrial content and metabolism, as well as lipid content in skeletal muscle cells. Specifically, cultured C2C12 myotubes were treated with either a control or HMB ranging from 6.25 to 25 μM for 24 h and mRNA and/or protein expression, oxygen consumption, glucose uptake, and lipid content were measured. Contrary to leucine's stimulatory effect on metabolism, HMB‐treated cells exhibited significantly reduced regulators of lipid oxidation including peroxisome proliferator‐activated receptor alpha (PPARα) and PPARβ/δ, as well as downstream target carnitine palmitoyl transferase, without alterations in glucose or palmitate oxidation. Furthermore, HMB significantly inhibited activation of the master regulator of energetics, AMP‐activated protein kinase. As a result, HMB‐treated cells also displayed reduced total mitochondrial content compared with true control or cells equivocally treated with leucine. Additionally, HMB treatment amplified markers of lipid biosynthesis (PPARγ and fatty acid synthase) as well as consistently promoted elevated total lipid content versus control cells. Collectively, our results demonstrate that HMB did not improve mitochondrial metabolism or content, and may promote elevated cellular lipid content possibly through heightened PPARγ expression. These observations suggest that HMB may be most beneficial for populations interested in stimulating anabolic cellular processes.     

Role of salt on adhesion of an epoxy/aluminum (oxide) interface in aqueous environments

Joints held by polymeric adhesives are commonplace in many engineered products, but normal service can require exposure to environmental conditions that present a significant challenge for maintaining the structural integrity of the interface. In particular, aqueous environments can wreak havoc on the joint strength. Here, a mechanistic approach is used to understand the difference in the debonding behavior of an epoxy/aluminum (oxide) interface when exposed to deionized (DI) water and aqueous sodium chloride by correlating macroscopic failure with the sorption of salt and water into the adhesive and its nanoscale distribution. For the epoxy‐aluminum system examined here, the presence of sodium chloride increases the resistance to crack growth in comparison to DI water. The debonding appears to be controlled by water near the buried interface. Salt water decreases the solubility of water in the epoxy and decreases the concentration of water near the buried interface, but the concentration of salt that enters the epoxy is below the detection limit. Thus, even if ions cannot penetrate or sorb into the adhesive, the presence of salt can significantly alter the water distribution within the adhesive and ultimately the strength of the joint. POLYM. ENG. SCI., 56:18–26, 2016. © 2015 Society of Plastics Engineers     

The Columnar-to-Equiaxed Transition in Melt Pools During Laser Powder Bed Fusion of M2 Steel

Metallurgical and Materials Transactions A - This work integrates experimental and numerical methods to determine the process conditions under which the columnar-to-equiaxed transition (CET)...