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Zusammenfassung. Es wird die Arbeitsweise der klinischen Ethik-Konsultation am Klinikum der Philipps-Universit?t Marburg anhand eines konkreten
Falles dargestellt. Grundlegend für diese Vorgehensweise ist die Theorie und Praxis eines Ethik-Konsildienstes, wie sie am
Medical Center der University of Virginia von J.C. Fletcher, F.G. Miller und J.J. Fins entwickelt wurde.
相似文献
43.
Selecting Al Alloys for Light Weight Heat Exchanger Fins Aluminium usage for heat exchangers for the motor car industry has increased significantly in recent years. The intrinsic advantage of aluminium alloys has enabled the replacement of traditional heat exchanger materials such as brass and copper. Alloy development has enabled the aluminium industry to prepare a range of alloys in different conditions and gauges that can meet the requirements of heat exchanger designers. This paper refers to the background for choice of available alloys and to development trends on a fitness for purpose basis. 相似文献
44.
We present an algorithm for computing generators for the ideal of algebraic relations among sequences which are given by homogeneous linear recurrence equations with constant coefficients. Knowing these generators makes it possible to use Gröbner basis methods for carrying out certain basic operations in the ring of such sequences effectively. In particular, one can answer the question whether a given sequence can be represented in terms of other given sequences. 相似文献
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Quantification is a major task in proteomics. Among the different analytical strategies to enable peptide and protein quantification, tagging with isotopic labels has emerged as a practical, versatile, and efficient alternative. In particular, isobaric labels, such as TMT or iTRAQ, are now widely employed to make relative comparison of the protein amounts in separate biological samples with tandem mass spectrometry (MS/MS). We used herein a shotgun proteomic approach based on labelling with tandem mass tags (TMTs) for the relative quantification of proteins, and the absolute quantification of their tryptic peptides in human cerebrospinal fluid (CSF). First, the comparison of ante- and post-mortem CSF samples was carried out for the discovery of protein marker candidates of brain-damage disorders. Second, tryptic peptides representative of these candidates were measured in CSF using reporter-ion calibration curves. These works highlighted the advantages and limitations of such strategies for quantification purposes in proteomics. 相似文献
48.
Hans‐Jörg Breyholz Dr. Stefan Wagner Dr. Andreas Faust Dr. Burkhard Riemann Prof. Dr. Carsten Höltke Dr. Sven Hermann Dr. Otmar Schober Prof. Dr. Michael Schäfers Prof. Dr. Klaus Kopka Priv.‐Doz. Dr. 《ChemMedChem》2010,5(5):777-789
Matrix metalloproteinases (MMPs) are zinc‐ and calcium‐dependent endopeptidases. Representing a subfamily of the metzincin superfamily, MMPs are involved in the proteolytic degradation of components of the extracellular matrix. Unregulated MMP expression, MMP dysregulation and locally increased MMP activity are common features of various diseases, such as cancer, atherosclerosis, stroke, arthritis, and others. Therefore, activated MMPs are suitable biological targets for the specific visualization of such pathologies, in particular by using radiolabeled MMP inhibitors (MMPIs). The aim of this work was to develop a radiofluorinated molecular probe for noninvasive in vivo imaging for the detection of up‐regulated levels of activated MMPs in the living organism. Fluorinated MMPIs ( 26 , 31 and 38 ) based on the pyrimidine‐2,4,6‐trione lead structure RO 28‐2653 ( 1 ) were synthesized, and their MMP inhibition potency was evaluated in vitro. The radiosynthesis and the in vivo biodistribution of the first 18F‐labeled prototype, MMP‐targeted tracer [18F] 26 , suitable for molecular imaging by means of positron emission tomography (PET) were realized. 相似文献
49.
Martin Gairing Thomas Lücking Marios Mavronicolas Burkhard Monien 《Theory of Computing Systems》2010,47(2):405-432
We consider the problem of routing n
users on m parallel links under the restriction that each user may only be routed on a link from a certain set of allowed links for the user. So, this problem is equivalent to the correspondingly restricted scheduling problem of assigning n
jobs to m parallel machines. In a Nash equilibrium, no user may improve its own Individual Cost (latency) by unilaterally switching to another link from its set of allowed links. 相似文献
50.
Dissolution of Alumina, Sintering, and Crystallization in Glass Ceramic Composites for LTCC 总被引:2,自引:0,他引:2
Ralf Müller Robert Meszaros Burkhard Peplinski Stefan Reinsch Markus Eberstein Wolfgang A. Schiller Joachim Deubener 《Journal of the American Ceramic Society》2009,92(8):1703-1708
Sintering and microstructure evolution of alkali-free calcium–alumo–borosilicate glass/α-Al2 O3 composites (mean particle size ca. 2 μm) for low-temperature cofired ceramics were studied during heating at 5 K/min by heating microscopy, thermal analysis (DTA), X-ray diffraction (XRD), and electron microscopy (SEM). Composites fully densify at ≈830°C, not essentially influenced by the dissolution of alumina and glass crystallization. Thus wollastonite, as first crystalline phase, was detectable at 840°C. Above 900°C, a pronounced crystallization of anorthite is evident, reaching 60 wt% at 1050°C. Rietveld analyses of XRD data revealed that anorthite precipitates at the expenses of alumina, which declines from ≈33 to <10 wt%, and wollastonite, which fully declines from its maximum of ≈19 wt%. Based on XRD, we discuss the evolution of crystal mass fractions, the residual glass composition, the glass viscosity, and the effective shear viscosity of the composites under study during heating. 相似文献