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121.
R Bookstein W Demers R Gregory D Maneval J Park K Wills 《Canadian Metallurgical Quarterly》1996,23(1):66-77
Tumor suppressor genes such as p53 contribute to the oncogenic process via loss-of-function mechanisms such as genetic mutation or complex formation with other cellular or viral proteins. p53 is mutated in approximately 50% of human tumors and has an important role in the genesis or progression of both colorectal and hepatocellular cancers. Colorectal cancer is leading cause of cancer mortality in the United States, whereas hepatocellular cancer is the leading worldwide cause of cancer death; the liver is a primary site of morbidity in both diseases. Because systemic tumor suppressor gene therapy is currently not feasible, we have chosen to develop a regional form of such therapy directed at primary or metastatic liver neoplasms. Gene replacement therapy with p53 is a promising new strategy to treat advanced human cancers. 相似文献
122.
14 medicated hypertensive, 15 nonmedicated mild hypertensive, 39 normotensive, and 13 hypotensive adults participated in a 1–2 hr laboratory experiment that assessed each S's symptoms, moods, and estimates of systolic blood pressure (SBP) relative to actual SBP levels. Several self-reports and autonomic measures were collected during and after each of 22 tasks. Within-S correlations indicated that all Ss could estimate SBP at levels greater than chance. Further, 68% of the Ss evidenced at least 1 significant symptom–SBP correlation. Although medicated hypertensives believed they could estimate their BP more accurately than other groups, they were actually no more accurate than the other Ss. They also evidenced far fewer empirically derived symptom–SBP and emotion–SBP correlations than any other group. Overall, blood pressure (BP) beliefs were largely inaccurate. If these erroneous beliefs can be eliminated, Ss may be able to estimate BP fluctuations more accurately. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
123.
124.
Croon J.A. Rosmeulen M. Decoutere S. Sansen W. Maes H.E. 《Solid-State Circuits, IEEE Journal of》2002,37(8):1056-1064
In this paper, a physics-based mismatch model is presented. It is demonstrated on a 0.18-/spl mu/m technology that a simple mismatch model can still be used to characterize deep-submicron technologies. The accuracy of the model is examined and found to be within 20% in the strong inversion region. Bulk bias dependence is modeled in a physical way. To extract the mismatch parameters, a weighted fit is introduced. It is shown that the width and length dependence of the mismatch parameters is given by the Pelgrom model. 相似文献
125.
Steinwandt R. Geiselmann W. 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2002,48(11):2990-2991
An attack on the public key cryptosystem Polly Cracker is described, that reveals the complete secret key σ ∈ Fq n by means of n (nonadaptively) chosen "fake" ciphertexts 相似文献
126.
Using AuGeNiCr multilayered metals as the wafer bonding medium, long-wavelength GaInAsP/InP vertical cavity surface emitting lasers employing Al-oxide/Si as the upper and lower distributed Bragg reflectors were fabricated on Si substrate with the bonding interface formed outside the vertical cavity surface emitting laser cavity. Laser emission at 1.545 μm was measured under pulsed operations near room temperature. The low-temperature metallic bonding process demonstrates a great potential in device fabrication 相似文献
127.
Wang J.R. Racette P. Tiesky M.E. Manning W. 《Geoscience and Remote Sensing, IEEE Transactions on》2002,40(6):1220-1229
The airborne Millimeter-wave Imaging Radiometer (MIR) measurements conducted over the Midwest region of the continental United States during January/February 1997 and over the Alaska-Arctic region during May 1998 are used to estimate column water vapor W<0.8 g/cm/sup 2/ under a clear sky. On board the same aircraft are two other instruments, the Cloud Lidar System (CLS) and MODerate-resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS), which provide cloud cover information and independent measurements of W, respectively. The MIR-estimated W values are compared and found to be in very good agreement with those measured by rawinsondes at near concurrence. A close correlation is found between the MIR-estimated W and that estimated from the MAS near-IR reflectance ratios. Water surface emissivities at several MIR frequencies are obtained in the process of the W retrieval from several flights over the Midwest lakes. These estimated emissivities compared favorably with values calculated for a calm water surface, which are based on a di-electric permittivity model and MAS-measured surface temperatures. The results from all comparisons strongly demonstrate the soundness of the technique for estimating W. 相似文献
128.
Development of a recurrent Sigma-Pi neural network rainfall forecasting system in Hong Kong 总被引:1,自引:1,他引:0
At the moment, weather forecasting is still an art — the experience and intuition of forecasters play a significant role in determining the quality of forecasting. This paper describes the development of a new approach to rainfall forecasting using neural networks. It deals with the extraction of information from radar images and an evaluation of past rain gauge records to provide shortterm rainfall forecasting. All of the meteorological data were provided by the Royal Observatory of Hong Kong (ROHK). Preprocessing procedures were essential for this neural network rainfall forecasting. The forecast of the rainfall was performed every half an hour so that a storm warning signal can be delivered to the public in advance. The network architecture is based on a recurrent Sigma-Pi network. The results are very promising, and this neural-based rainfall forecasting system is capable of providing a rain storm warning signal to the Hong Kong public one hour ahead. 相似文献
129.
130.
Recent observations at operating plants and subsequent US NRC requirements have identified flow stratification in surge lines as a phenomenon that must be considered in the design basis of surge lines. To address these concerns, the stratified loading conditions were included in the design of YGN 3 and 4 surge line as a design basis transient and pipe temperature and displacement measurement were taken during YGN 3 pre-core hot functional testing to determine the degree of surge line flow stratification. The measured displacements and temperatures were extensively reviewed and evaluated in detail: (1) to verify the validity of the thermal hydraulic model used to predict the pipe top-to-bottom temperature differentials; (2) to analytically correlate measured surge line temperatures and displacements; and (3) to confirm the validity of the stratified flow analysis procedure. This paper shows that the stratified flow phenomenon is generic and therefore generic loadings can be developed and evaluated for the surge line analyses. 相似文献