Reducing the overhead of dynamic compilation

The execution model for mobile, dynamically‐linked, object‐oriented programs has evolved from fast interpretation to a mix of interpreted and dynamically compiled execution. The primary motivation for dynamic compilation is that compiled code executes significantly faster than interpreted code. However, dynamic compilation, which is performed while the application is running, introduces execution delay. In this paper we present two dynamic compilation techniques that enable high performance execution while reducing the effect of this compilation overhead. These techniques can be classified as (1) decreasing the amount of compilation performed, and (2) overlapping compilation with execution. We first present and evaluate lazy compilation, an approach used in most dynamic compilation systems in which individual methods are compiled on‐demand upon their first invocation. This is in contrast to eager compilation, in which all methods in a class are compiled when a new class is loaded. In this work, we describe our experience with eager compilation, as well as the implementation and transition to lazy compilation. We empirically detail the effectiveness of this decision. Our experimental results using the SpecJVM Java benchmarks and the Jalapeño JVM show that, compared to eager compilation, lazy compilation results in 57% fewer methods being compiled and reductions in total time of 14 to 26%. Total time in this context is compilation plus execution time. Next, we present profile‐driven, background compilation, a technique that augments lazy compilation by using idle cycles in multiprocessor systems to overlap compilation with application execution. With this approach, compilation occurs on a thread separate from that of application threads so as to reduce intermittent, and possibly substantial, delay in execution. Profile information is used to prioritize methods as candidates for background compilation. Methods are compiled according to this priority scheme so that performance‐critical methods are invoked using optimized code as soon as possible. Our results indicate that background compilation can achieve the performance of off‐line compiled applications and masks almost all compilation overhead. We show significant reductions in total time of 14 to 71% over lazy compilation. Copyright © 2001 John Wiley & Sons, Ltd.     

Asplenia syndrome in conjoined twins: a case report

Incomplete fission of the primordial cell mass is generally believed to be the cause of conjoined twinning. It may also explain the tendency towards increased symmetry in these twins. We report a case of the rostral duplication type of conjoined twins with an absence of symmetry; one twin had the asplenia syndrome, whereas the other twin was normal. Local environmental factors acting upon the organ anlage may explain the asymmetric development in these conjoined twins.     

Path Analysis and Renaming for Predicated Instruction Scheduling

Increases in instruction level parallelism are needed to exploit the potential parallelism available in future wide issue architectures. Predicated execution is an architectural mechanism that increases instruction level parallelism by removing branches and allowing simultaneous execution of multiple paths of control, only committing instructions from the correct path. In order for the compiler to expose and use such parallelism, traditional compiler data-flow and path analysis needs to be extended to predicated code. In this paper, we motivate the need for renaming and for predicates that reflect path information. We present Predicated Static Single Assignment (PSSA) which uses renaming and introduces Full -Path Predicates to remove false dependences and enable aggressive predicated optimization and instruction scheduling. We demonstrate the usefulness of PSSA for Predicated Speculation and Control Height Reduction. These two predicated code optimizations used during instruction scheduling reduce the dependence length of the critical paths through a predicated region. Our results show that using PSSA to enable speculation and control height reduction reduces execution time from 12 to 68%.     

Android手机打造Web服务器

正随着IT技术的不断进步,智能手机的更新换代也正在逐渐加快,但替换下来的旧手机仍旧有很强的性能,如果就此放置一旁无疑是一种极大的浪费。除了将手机作为二手产品低价出售,还有什么办法能够让手机物尽其用呢?Android手机如今已经成为人们生活、工作必备的设备。相信如果你某天找不到手机,那么你一天的生活节奏一定会被弄的混乱不堪。随着IT技术的不断进步,智能手机的更新换代也正在逐渐加快,但替换下来的旧手机仍旧有很强的性能,如果就此放置一旁无疑是一种极大的浪费。     

Toward a user-guided manipulation framework for high-DOF robots with limited communication

This paper presents our progress toward a user-guided manipulation framework for high degree-of-freedom robots operating in environments with limited communication. The system we propose consists of three components: (1) a user-guided perception interface that assists the user in providing task-level commands to the robot, (2) planning algorithms that autonomously generate robot motion while obeying relevant constraints, and (3) a trajectory execution and monitoring system which detects errors in execution. We report quantitative experiments performed on these three components and qualitative experiments of the entire pipeline with the PR2 robot turning a valve for the DARPA robotics challenge. We also describe how the framework was ported to the Hubo2+ robot with minimal changes which demonstrates its applicability to different types of robots.     

An algorithm to estimate soil moisture over vegetated areas based on in situ and remote sensing information

An algorithm is proposed for estimating soil moisture over vegetated areas. The algorithm uses in situ and remote sensing information and statistical tools to estimate soil moisture at 1 km spatial resolution and at 20 cm depth over Puerto Rico. Soil moisture within the study region is characterized by spatial and temporal variability. The temporal variability for a given area exhibits long- and short-term variations that can be expressed by two empirical models. The average monthly soil moisture exhibits the long-term variability and is modelled by an artificial neural network (ANN), whereas the short-term variability is determined by hourly variation and is represented by a nonlinear stochastic transfer function model. Monthly vegetation index, land surface temperature, accumulated rainfall and soil texture are the major drivers of the ANN to estimate the monthly soil moisture. Radar, satellite and in situ observations are the major sources of information of the soil moisture empirical models. A self-organized ANN was also used to identify spatial variability to be able to determine a similar transfer function that best resembles the properties of a particular grid point and estimate the hourly soil moisture across the island. Validation techniques reveal an average absolute error of 3.34% of volumetric water content and this result shows that the proposed algorithm is a potential tool for estimating soil moisture over vegetated areas.     

Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro

Many enteroviruses, members of the family Picornaviridae, cause a rapid and drastic inhibition of host cell protein synthesis during infection, a process referred to as host cell shutoff. Poliovirus, one of the best-studied enteroviruses, causes marked inhibition of host cell translation while preferentially allowing translation of its own genomic mRNA. An abundance of experimental evidence has accumulated to indicate that cleavage of an essential translation initiation factor, eIF4G, during infection is responsible at least in part for this shutoff. However, evidence from inhibitors of viral replication suggests that an additional event is necessary for the complete translational shutoff observed during productive infection. This report examines the effect of poliovirus infection on a recently characterized 3' end translational stimulatory protein, poly(A)-binding protein (PABP). PABP is involved in stimulating translation initiation in lower eukaryotes by its interaction with the poly(A) tail on mRNAs and has been proposed to facilitate 5'-end-3'-end interactions in the context of the closed-loop translational model. Here, we show that PABP is specifically degraded during poliovirus infection and that it is cleaved in vitro by both poliovirus 2A and 3C proteases and coxsackievirus B3 2A protease. Further, PABP cleavage by 2A protease is accompanied by concurrent loss of translational activity in an in vitro-translation assay. Similar loss of translational activity also occurs simultaneously with partial 3C protease-mediated cleavage of PABP in translation assays. Further, PABP is not degraded during infections in the presence of guanidine-HCl, which blocks the complete development of host translation shutoff. These results provide preliminary evidence that cleavage of PABP may contribute to inhibition of host translation in infected HeLa cells, and they are consistent with the hypothesis that PABP plays a role in facilitating translation initiation in higher eukaryotes.     

One protein, two enzymes

Two enzymes, designated, E-2 and E-2', catalyze different oxidation reactions of an aci-reductone intermediate in the methionine salvage pathway. E-2 and E-2', overproduced in Escherichia coli from the same gene, have the same protein component. E-2 and E-2' are separable on an anion exchange column or a hydrophobic column. Their distinct catalytic and chromatographic properties result from binding different metals. The apo-enzyme, obtained after metal is removed from either enzyme, is catalytically inactive. Addition of Ni2+ or Co2+ to the apo-protein yields E-2 activity. E-2' activity is obtained when Fe2+ is added. Production in intact E. coli of E-2 and E-2' depends on the availability of the corresponding metals. These observations suggest that the metal component dictates reaction specificity.     

Superconducting gap function and upper critical field in the presence of inhomogeneous magnetic order

Rare earth ternary superconductors are known to exhibit oscillatory magnetic orders below their superconducting transition temperatures. The study of behaviour of superconducting electrons in an inhomogeneous magnetic field is therefore important for such systems. We report here the results of our theoretical study of superconducting gap function Δ(T) and upper critical fieldH _c2 (T). The results are applied to analyse and explain the variation of Δ(T) andH _c2 (T) in case of NdRh₄B₄.