User interface modeling in UMLi

Although user interfaces represent an essential part of software systems, the Unified Modeling Language )UML) seems to have been developed with little specific attention given to user interface issues. Several researchers have investigated integrating interface modeling techniques with UML. In UML, one models tasks using extended activity diagrams rather than by incorporating a completely new notation into UML. UMLi also addresses the relationships between use cases, tasks, and views, and thoroughly addresses the relationship between tasks and the data on which they act. UMLi is probably the most technically mature proposal for interface development in UML.     

Parallel processing applied to the planning of hydrothermal systems

The objective of the long-term operating planning problem is to determine the optimum strategy for the generation of electricity, aiming toward the minimization of total operating cost over the planning period. In a competitive electricity market, with the participation of a significant number of hydroplants, such as in Brazil, precision modelling for operating planning is required so that a better use of hydraulic resources can be obtained. We present a long-term operating planning model based on an individual power plant representation. In order to support the high computational burden, a suitable parallel processing algorithm is proposed.     

基于SDL/MSC的实时嵌入式系统概念级设计

概念级设计是实时嵌入式系统设计自动化的第一步 ,由于它的性能直接关系到整个系统的设计质量 ,所以也是非常重要的一步 .除了对所设计系统的功能进行描述、验证之外 ,概念级设计还应该对所设计系统的性能进行分析 .否则 ,如果将错误带到下一阶段 ,将会使整个设计付出沉重的代价 .在简单介绍了实时嵌入式系统的自动化设计原理 ,并分析了目前人们采用的三种概念级设计方法缺点之后 ,文章提出了基于 SDL / MSC描述与验证的 ,适用于单 FPGA或多 FPGA系统的概念级设计方法 .这种方法包括系统的 SDL/ MSC描述与验证、有向无环图 (DAG)的产生、DAG子图划分等几部分 .在文章的最后 ,还指出了这种设计方法存在的不足     

Dynamic multi-commodity capacitated facility location: a mathematical modeling framework for strategic supply chain planning

In this paper, we focus on the strategic design of supply chain networks. We propose a mathematical modeling framework that captures many practical aspects of network design problems simultaneously but which have not received adequate attention in the literature. The aspects considered include: dynamic planning horizon, generic supply chain network structure, external supply of materials, inventory opportunities for goods, distribution of commodities, facility configuration, availability of capital for investments, and storage limitations. Moreover, network configuration decisions concerning the gradual relocation of facilities over the planning horizon are considered. To cope with fluctuating demands, capacity expansion and reduction scenarios are also analyzed as well as modular capacity shifts. The relation of the proposed modeling framework with existing models is discussed. For problems of reasonable size, we report on our computational experience with standard mathematical programming software. In particular, useful insights on the impact of various factors on network design decisions are provided.     

From a Conceptual Framework for Agents and Objects to a Multi-Agent System Modeling Language

In this paper we propose a multi-agent system modeling language (MAS-ML) that extends UML (Unified Modeling Language) based on structural and dynamic properties presented in a conceptual framework (metamodel) called Taming Agents and Objects (TAO). Our focus is the adaptation according to TAO concepts of the static Class diagram and the interaction Sequence diagram proposed by UML. These two diagrams have been chosen because they are the most commonly used and because it is possible to use them to illustrate both the structural and dynamic aspects of TAO metamodel. We propose a conservative extension of the UML metamodel, which includes agent-related notions that are part of the TAO conceptual framework while preserving all object-related concepts, which constitute the UML metamodel. The main difference between our approach and the others presented in the literature is the clear definition and representation of the elements that compose MASs and their corresponding behavior. In order to extend UML with TAO non-object concepts, it is not possible to use only the three basic extensions mechanisms provided by UML and new metaclasses and stereotypes have been created and associated with the UML metamodel.     

国产材料阻性板室特性研究

介绍了国产酚醛层压板制成的阻性板室在宇宙线测试条件下的特性,效率达到95％左右,时间分辨的半高宽为2．25ns。     

Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes

Curcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or curcuminoid (52.4 mg/kg/day). Fasting glycaemia, insulin tolerance, plasma insulin, insulin signalling, serum FFA, endothelial function and several markers of oxidative stress were evaluated. Both compounds presented a significant anti-inflammatory effect. Moreover, the curcuminoid had a marked hypoglycaemic effect, accompanied by higher GLUT4 levels in adipose tissue. Both compounds increased NO-dependent vasorelaxation, but only the curcuminoid exacerbated the response to ascorbic acid, consistent with a higher decrease in vascular oxidative and nitrosative stress. SOD1 and GLO1 levels were increased in EAT and heart, respectively. Altogether, these data suggest that the curcuminoid developed here has more pronounced effects than curcumin in low doses, improving the oxidative stress, endothelial function and glycaemic profile in type 2 diabetes.     

Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach

Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients’ samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs’ roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia.     

Electromagnetic Devices Applications of EBG for Systems Communications

This paper presents the study and applications of EBG (Electromagnetic Band Gap)/PBG (Photonic Band Gap) substrates, of planar microstrip structures, including quadrature directional couplers, rat-race (ring coupler) and impedance transformers. Through specific programs developed in FORTRAN PowerStation, the frequencies and couplings for each structure are obtained. Also are used the PACMO—Computer Aided Design in Microwave program developed by H.C.C. Fernandes. Results of the dimensions and coupling of these devices, varying the frequency band (cellular communication and Wimax systems) and permittivity of the substrate, are obtained, comparing the results of conventional materials with EBG/PBG materials in the s and p polarizations.     

Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?

The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic.