A turbulent environment characterized by unsteady economic cycles, customized products, a growing bandwidth of products, an exploding number of variants and shorter product life cycles force manufacturers to permanent adaptation of their factories. Flexible and changeable structures will be required to enable factories dealing with the technological challenges and economic pressure of the future competitively. In order to achieve changeability objectives in manufacturing, a detailed analysis of existing structures and its representative attributes is essential. It is the basis for systematic structure planning of factories. In this paper a method for analyzing the capacitive and technological structure of a factory embedded in a network of manufacturing and its network of suppliers is presented. The synchronization of product and production development under the influence of change is intended. Therefore, the structural views of product and production are specifically in focus of the method. Based on the results of the analysis models an approach of a tool for giving product and production structure dynamism is suggested to investigate the effects and dependencies of change drivers in manufacturing. 相似文献
Musculoskeletal disorders are more common among women than among men. When comparing the difference between men and women in the prevalence of musculoskeletal disorders, methodological problems arise as men and women seldom perform the same type of activities, neither at work nor at home.
The main objective of this cross-sectional case study was to compare work technique and self-reported musculoskeletal symptoms between men and women performing the same type of work tasks within a metal industry. Other factors, such as leisure activities, were also taken into consideration. Three data collection methods were used; questionnaire, interviews and systematic observations. The results from the observations revealed that women worked more frequently and during longer times with their hands above shoulder height than men. Working with hands above shoulder height is considered a risk factor for neck and shoulder disorders according to previous studies. Workplace design factors were probably a reason for differences in working technique between men and women. A higher proportion of women than men reported shoulder symptoms. Women spent more time on household activities than men, which indicates a higher total workload in paid and unpaid work. 相似文献
The influence of high-pressure homogenisation (HPH) at 100 MPa on Lacticaseibacillus paracasei 90 (L90) was studied in vitro and in situ (fermented milk and cheese). Lysis and injury signs were observed in cells treated with HPH, which were linked to the release of intracellular enzymes and changes in the metabolic activity of L90. HPH treatment led to a higher lactic acid content and lower pH and pyruvic acid levels in fermented milk. The microbiological and peptide profiles of cheeses were modified by using cells or cell-free extracts of L90. Finally, this study suggests that L90 could release bioactive peptides. 相似文献
Obesity and its associated metabolic disorders, such as T2DM and MeS, are a growing public health problem worldwide. Our goal was the identification of protein patterns that are uniquely characteristic of higher BMI, MeS, and T2DM in a Brazilian population. 相似文献
We introduce a robust estimator of the location parameter for the change‐point in the mean based on Wilcoxon statistic and establish its consistency for L1 near‐epoch dependent processes. It is shown that the consistency rate depends on the magnitude of the change. A simulation study is performed to evaluate the finite sample properties of the Wilcoxon‐type estimator under Gaussianity as well as under heavy‐tailed distributions and disturbances by outliers, and to compare it with a CUSUM‐type estimator. It shows that the Wilcoxon‐type estimator is equivalent to the CUSUM‐type estimator under Gaussianity but outperforms it in the presence of heavy tails or outliers in the data. 相似文献
Digital Twins are new solution elements to enable ongoing digital monitoring and active functional improvement of interconnected products, devices and machines. In addition, benefits of horizontal and vertical integration in manufacturing are targeted by the introduction of Digital Twins. Using the test environment of smart factory cells, this paper investigates methodological, technological, operative, and business aspects of developing and operating Digital Twins. The following Digital Twin dimensions are considered in scientific and application oriented analysis: (1) integration breadth, (2) connectivity modes, (3) update frequency, (4) CPS intelligence, (5) simulation capabilities, (6) digital model richness, (7) human interaction, and (8) product lifecycle. From this, design elements for the development of Digital Twins are derived and presented. 相似文献
Reinforced Concrete Beams With Openings – A Simplified Design Concept – A comprehensive design concept for reinforced concrete beams with large openings was presented in Beton‐ und Stahlbetonbau 97, booklet 3, 2002. In recent years six laboratory tests were carried out to verify the design concept. Additionally extensive Finite Element computations with physically nonlinear material models were conducted to analyse the structural behaviour of reinforced concrete beams with opening groups. In this paper a simplified design concept for reinforced concrete beams with large openings and opening groups is presented which is based on the results of the test series and the FE‐computations. 相似文献