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排序方式: 共有187条查询结果,搜索用时 15 毫秒
181.
Monari?EmanuelaEmail author Cuoghi?Aurora Bellei?Elisa Bergamini?Stefania Caiazzo?Marialuisa Aucella?Filippo Loschiavo?Carmelo Corazza?Luca Palladino?Giuseppe Sereni?Luisa Atti?Mauro Tomasi?Aldo 《Journal of materials science. Materials in medicine》2014,25(12):5290
In end-stage renal disease patients, extracorporeal dialytic therapy is not able to prevent the accumulation of toxins related to the uremic syndrome, a severe complication that increases morbidity and mortality rate. In this paper, hemoFiltration with on-line Reinfusion (HFR) architecture is used to evaluate the effect of a more permeable membrane on the extraction of medium–high molecular weight molecules. The aim of this study was to compare two polysulphone membranes for convective chamber: polyphenylene High Flux (pHF) and polyphenylene Super High-Flux (pSHF). Fourteen patients were subjected to HFR with pHF and pSHF membranes and ultra filtrate (UF) samples were collected to evaluate molecular weight cut-off (MWCO) and to identify extracted proteins. Furthermore, image analysis software was used in order to evaluate change in protein extraction during the dialysis. The quantification of four proteins by immunoassay demonstrates a higher permeability of pSHF membrane. Two-dimensional electrophoresis (2-DE) gels showed, for both membranes, the greater number of protein spots at 235 min. Some of the identified proteins, involved in nephropathic disease complications, were compared to assess differences in extraction during dialytic treatment by PDQuest analysis. UF proteomic analysis demonstrated a different behavior for the two membranes; pHF membrane was more permeable at the beginning of HFR treatment (15 min), while pSHF membrane at the end of treatment (235 min). Proteomic analysis is a suitable approach to investigate the behavior of different membranes during dialysis. Results indicated that pSHF membrane offers the higher permeability, and showed higher efficiency in removal of middle molecules related to uremic syndrome. 相似文献
182.
Carmelo García Barroso Rafael Cela Torrijos Juan Antonio Pérez-Bustamante 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1987,185(4):307-314
Summary The different groups and/or classes among phenolic acids and aldehydes identified during the elaboration process of fino sherry wine have been studied. The study was carried out using different processes during the elaboration of the wine and we have attempted to establish whether the different treatments of the grape affect these groupings. The study was undertaken by means of cluster and multifactorial analysis on the data obtained by the quantitative determination of phenolic acids and aldehydes during viniffcation and in experiments carried out on the grape under different mechanical treatments. The analysis of phenolic acids and aldehydes was done with HPLC, using a C-18-Bondapak and a stepwise composite gradient. The samples were previously extracted with ethylic ether.
Eine Studie über das Verhalten von Polyphenolen in Fino Sherry Wein. Entwicklung wahrend der Weinherstellung und mechanischen Behandlun der Traube
Zusammenfassung Die verschiedenen Gruppen und/oder Klassen unter den phenolischen Säuren und Aldehyden wurden während der Weinherstellung identifziert. Diese Studie wurde während der verschiedenen Prozesse der Bearbeitung des Weines ausgeführt und wir haben versucht, festzustellen, ob die verschiedenen Behandlungen der Trauben these Gruppierungen beeinflussen. Die Studie wurde mit Hilfe von Cluster-und Multifactorial-Analysen mit den erhaltenen quantitativen Bestimmungen der phenolischen Säuren und Aldehyden durchgeführt. Die Analysen der phenolischen Säuren und Aldehyden wurden mit der HPLC unter Anwendung von C-18-Bondapak durchgeführt. Die Proben wurden vorher mit Ethylether extrahiert.相似文献
183.
Tirella A Vozzi F De Maria C Vozzi G Sandri T Sassano D Cognolato L Ahluwalia A 《Journal of Bioscience and Bioengineering》2011,112(1):79-85
The adaptation of inkjet printing technology for the realisation of controlled micro- and nano-scaled biological structures is of great potential in tissue and biomaterial engineering. In this paper we present the Olivetti BioJet system and its applications in tissue engineering and cell printing. BioJet, which employs a thermal inkjet cartridge, was used to print biomolecules and living cells. It is well known that high stresses and forces are developed during the inkjet printing process. When printing living particles (i.e., cell suspensions) the mechanical loading profile can dramatically damage the processed cells. Therefore computational models were developed to predict the velocity profile and the mechanical load acting on a droplet during the printing process. The model was used to investigate the role of the stiffness of the deposition substrate during droplet impact and compared with experimental investigations on cell viability after printing on different materials. The computational model and the experimental results confirm that impact forces are highly dependent on the deposition substrate and that soft and viscous surfaces can reduce the forces acting on the droplet, preventing cell damage. These results have high relevance for cell bioprinting; substrates should be designed to have a good compromise between substrate stiffness to conserve spatial patterning without droplet coalescence but soft enough to absorb the kinetic energy of droplets in order to maintain cell viability. 相似文献
184.
185.
Roberta Pecoraro Antonio Salvaggio Elena M. Scalisi Carmelo Iaria Giovanni Lanteri Chiara Copat Margherita Ferrante Giuseppe Fragal Massimo Zimbone Giuliana Impellizzeri Maria V. Brundo 《Microscopy research and technique》2019,82(8):1297-1301
Although in recent years there has been intensification in the use of nanoparticles (NPs) for the production of many commercial products, few studies have been carried out to assess the risks associated with its use. Among the most used NPs, silver nanoparticles (AgNPs) have a preponderant position as they have various applications. In this study, 40 adult zebrafish were exposed to increasing concentrations of AgNPs (8, 45, and 70 μg/L) for 30 days to evaluate the effects on eyes after chronic exposure to AgNPs with an average diameter of 50 nm. From the morphological and ultrastructural analysis performed, no alteration or lesions of the corneal epithelium were detected. 相似文献
186.
Carmelo De Maria Irene Chiesa Davide Morselli Maria Rachele Ceccarini Silvia Bittolo Bon Micaela Degli Esposti Paola Fabbri Antonino Morabito Tommaso Beccari Luca Valentini 《Advanced functional materials》2021,31(52):2105665
Taking inspiration from plant tendril geometry, in this study, 4D bimorph coiled structures with an internal core of graphene nanoplatelets-modified regenerated silk and an external shell of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) are fabricated by 4D printing. Finite element simulations and experimental tests demonstrate that integrating these biomaterials with different coefficients of thermal expansion results in the temperature induced self-compression and torsion of the structure. The bimorph spring also exhibits reversible contractive actuation after exposure to water environment that paves its exploitation in regenerative medicine, since core materials also have been proven to be biocompatible. Finally, the authors validate their findings with experimental measurements using such springs for temperature-mediated lengthening of an artificial intestine. 相似文献
187.
Michela Campolo Alessia Filippone Carmelo Biondo Giuseppe Mancuso Giovanna Casili Marika Lanza Salvatore Cuzzocrea Emanuela Esposito Irene Paterniti 《International journal of molecular sciences》2020,21(24)
Neuroinflammation and autoimmune mechanisms have a key part in the pathogenesis of Parkinson’s disease (PD). Therefore, we evaluated the role of Toll-like receptors (TLRs) as a link between inflammation and autoimmunity in PD. An in vivo model of PD was performed by administration of 1-metil 4-fenil 1,2,3,6-tetraidro-piridina (MPTP) at the dose of 20 mg/kg every 2 h for a total administration of 80/kg, both in single Knock Out (KO) mice for TLR7, TLR 8, and TLR9 and in double KO mice for TLR 7/8-/-. All animals were compared with WT animals used as a control group. All animals were sacrificed after 7 days form the first administration of MPTP. The genetic absence of TLR 7 and 8 modified the PD pathway, increasing the immunoreactivity for TH and DAT compared to PD groups and decreasing microglia and astrocytes activation. Moreover, the deletion of TLR7 and TLR8 significantly reduced T-cell infiltration in the substantia nigra and lymph nodes, suggesting a reduction of T-cell activation. Therefore, our result highlights a possibility that an immunotherapy approach, by using a dual antagonist of TLR 7 and 8, could be considered as a possible target to develop new therapies for Parkinson diseases. 相似文献