Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age

The temporal trends and influence of age and gender on levels of selected brominated flame retardants (BFRs) in human serum have been assessed by analyzing archived samples from Norway. Serum from 40 to 50 year old men collected at six time periods during 1977 to 1999 and from eight groups of differing age and gender sampled in 1998 were pooled into six and eight samples, respectively. The BFRs were isolated using solid-phase extraction (SPE) and the serum lipids decomposed bytreatmentwith concentrated sulfuric acid directly on the polystyrene-divinylbenzene SPE column, prior to elution of the BFRs. Following diazomethane derivatization, the samples were analyzed by gas chromatography-electron capture mass spectrometry. Eight BFRs were quantified in the serum samples: 2,4,4'-tribromodiphenyl ether (BDE-28), 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), 2,2',4,4',6-pentabromodiphenyl ether (BDE-100), 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153), 2,2',4,4',5,6'-hexabromodiphenyl ether (BDE-154), 2,4,6-tribromophenol (TriBP), and tetrabromobisphenol A (TBBP-A). The serum concentrations of all the BFRs, increased during the entire period with the exception of TriBP, and the sum of the six polybrominated diphenyl ethers increased from 0.44 ng/g lipids in 1977 to 3.3 ng/g lipids in 1999. The BFR concentrations in the serum from the different age groups were relatively similar, except for the age group 0-4 years, which had 1.6-3.5 times higher serum concentrations. Women older than 25 years had lower serum concentrations of BFRs compared to the corresponding group of men. No trend related to age or gender, nor time during the period 1977 to 1999 was observed for TriBP. The present study indicates an ongoing increase in human exposure to BFRs, and the current body burden appears to be independent of age, except for infants (0-4 years old), who seem to experience elevated exposure.     

Household and workplace chemicals as retrospective luminescence dosemeters

In the development of techniques for the retrospective assessment of the dose absorbed by communities living and working adjacent to the site of a nuclear accident, attention has concentrated on the use of natural minerals such as quartz and feldspar as dosemeters. These minerals are widely found in household earthenware and almost all types of bricks and concrete. Their main disadvantages are variable and often low sensitivity, and the possibility of a comparatively large natural dose prior to the accident, depending on the age of the building and the type or building material. However, there are other potential unheated crystalline materials found in the domestic and industrial environment which may also act as retrospective dosemeters, and may be considerably more sensitive. We have surveyed the thermoluminescent and optically stimulated luminescent (OSL) characteristics of several such chemicals and this paper reports on the OSL sensitivity, the size of the residual dose immediately after manufacture, stability and derived minimum detection limits.     

Control volume based modelling in one space dimension of oscillating, compressible flow in reciprocating machines

We present an approach for modelling unsteady, primarily one-dimensional, compressible flow. The conservation laws for mass, energy, and momentum are applied to a staggered mesh of control volumes and loss mechanisms are included directly as extra terms. Heat transfer, flow friction, and multidimensional effects are calculated using empirical correlations. Transformations of the conservation equations into new variables, artificial dissipation for dissipating acoustic phenomena, and an asymmetric interpolation method for minimising numerical diffusion and non physical temperature oscillations are presented. The capabilities of the approach are illustrated with an example solution and an experimental validation of a Stirling engine model.     

Meniere's disease. A neuropsychological study

A neuro-psychological study is described comprising 19 patients with Meniere's Disease who were participating in an experimental lithium therapy programme. The patients evidenced an organic dysfunction which is not entirely periphearl. The interpretation of the results are not incompatible with an attempt to reconcile neuro-psychological and psycho-somatic viewpoints regarding etiological aspects of Meniere's Disease. An evaluation of the lithium effect was performed.     

In vivo/ex vivo cellular interactions with titanium and copper

Machined, commercially pure titanium (Ti) disks were coated with approximately 400 nm copper (Cu) by physical vapor deposition or left uncoated. The kinetics of inflammatory cell recruitment, distribution and viability was evaluated around Ti, Cu, and in sham sites after 1, 3, 12, 18, 24, and 48 h in a rat subcutaneous (s.c.) model. Further analysis of the cells on implant surfaces was performed by ex vivo incubation of the disks. Ti and Cu stimulated an increased recruitment of inflammatory cells in comparison with sham sites. A markedly higher amount of cells, predominantly polymorpho-nuclear granulocytes (PMN), was detected around Cu after 18 h and onwards. More cells were found at the implant surfaces than in the surrounding exudates after 18 h. The total amount of lactate dehydrogenase (LDH), an indicator of plasma membrane injury, was higher in Cu exudates after 18 h in comparison with Ti and sham. In contrast, no differences in the proportion of dead cells (trypan blue dye uptake) were detected in the exudates. Further, LDH levels were higher around Ti than Cu during the initial 18 h of ex vivo incubation. The results of this study indicate that the early inflammatory process associated with a cytotoxic material in soft tissues is largely attributed to the induction of a markedly strong and prolonged chemotactic response. In contrast, this process is characterized by a higher amount of inflammatory cells around a biocompatible material than in sham sites, but with a transient course and total LDH similar to sham sites.     

New peel stopper concept for sandwich structures

The paper addresses the damage tolerance of sandwich structures, where the prevention and limitation of delamination failure are highly important design issues. Due to the layered composition of sandwich structures, face–core interface delamination is a commonly observed failure mode, often referred to as peeling failure. Peeling between the sandwich face sheets and the core material drastically diminishes the structural integrity of the structure. This paper presents a new peel stopper concept for sandwich structures. Its purpose is to effectively stop the development of debonding/delamination by rerouting the delamination, and to confine it to a predefined zone in the sandwich structure. The suggested design was experimentally tested for different material compositions of sandwich beams subjected to three-point bending loading. For all the tested sandwich configurations the suggested peel stopper was able to stop face–core delamination and to limit the delamination damage to restricted zones.     

An examination of nonresponse in a work environment questionnaire mailed to psychiatric health care personnel.

Nonresponse to surveys, which seems to plague work environment studies and studies of health care personnel in particular, may pose problems of generalizability and validity. The aim of this study was to provide an estimate of nonresponse error in a self-administered survey concerning the work environment of psychiatric health care personnel. A random sample of 10% of the original survey population (N?=?693) was selected to participate in a telephone follow-up of a postal survey that had a response rate of 51%. There were no differences between the responders and nonresponders to the postal survey on the exposure or outcome variables. There was no evidence of nonresponse bias in this study, although recall bias may have been a problem. In those cases in which generalizability is deemed important, it is recommended that nonresponse studies be regularly carried out when response rates are less than 100%. (PsycINFO Database Record (c) 2010 APA, all rights reserved)