Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 under the dose of 100 mg/kg increased the signal intensity of NOFe2+(DETC)2 complex, while EGb 761 at 200 mg/kg showed an effect of decreasing the signal intensity of NOFe2+(DETC)2 complex. EGb 761 inhibited the formation of TBARS, the release of CK, and mitigated the incidence of ventricular arrhythmias in a dose dependent way. Both l-arginine and SOD increased the signal intensity of NOFe2+(DETC)2 complex and inhibited the formation of TBARS, the leakage of CK and the incidence of ventricular arrhythmia. NNA not only had no protective effects on myocardial injury, but also increased the incidence of reperfusion-induced arrhythmia. In conclusion, EGb 761 has cardiovascular protective effects by means of adjusting the level of NO and inhibiting oxygen free radicals induced lipid peroxidation in myocardial ischemia-reperfusion injury in vivo.     

As,Sb,Sn对30CrMnSiA钢力学性能的影响

在３０ＣｒＭｎＳｉＡ钢中加入不同量的Ａｓ，Ｓｂ，Ｓｎ元素，研究了这些元素单独存在及复合存在时对钢的强度，塑性，冲击韧度及韧脆转变温度的影响规律，并用扫描电镜及俄歇能谱分析了Ａｓ，Ｓｂ，Ｓｎ导致晶界脆化的机理。     

Granular multiple kernel learning for identifying RNA-binding protein residues via integrating sequence and structure information

Neural Computing and Applications - RNA-binding proteins play an important role in the biological process. However, the traditional experiment technology to predict RNA-binding residues is...     

一种新的无线电高度表原位检测的高度模拟方法

针对目前对高度表进行原位检测的需求,设计了一种新的高度模拟方法;该方法的实现以ARM为核心,通过高度模拟电路产生各种需要的高度电压信号,从而达到高度模拟的目的,并且无需对机载高度表进行拆装,操作简单、快捷、可靠性较高;实验结果表明,这种方法的高度模拟精度较高,具有一定的实用价值和经济效益.     

RFID技术在智能交通管理中应用

本文主要介绍RFDI技术定义及系统工作原理,并重点关注RFID技术在智能交通领域的实际应用方式。同时RFID技术也成功解决了车辆自动识别和信息采集问题,为智能交通管理和服务系统的建立提供了强大的信息支撑和保障。     

火力发电厂自动加氧处理系统的研究与应用

针对超(超)临界机组不采用加氧处理,给水系统容易发生流动加速腐蚀(影响安全)、水冷壁结垢速率高(降低锅炉效率)、锅炉酸洗周期短(影响效益)、水冷壁节流孔堵塞(影响安全)、凝结水精处理运行周期短(影响节能减排)等实际问题,通过融合预测控制技术及自适应控制技术,提出了符合现代火电机组加氧工况要求的先进解决方案自动加氧装置.该技术通过研制加氧流量传感器,产生与氧气流量对应的电子信号,将与流量相关的电子信号送到PLC,与流量设定值进行比对,再调节氧气流量调节门,实现加氧量的精准控制,最终实现闭环控制,并能有效减少在稳定工况及升、降负荷过程中凝结水、给水氧量关键参数的波动,控制参数十分平稳,确保了大型火电机组的安全、稳定及高效运行.     

Characterization of ultrafine La x Sr1−x MnO3 powder prepared by spray pyrolysis

The characterization of La _x Sr_1−x MnO₃ powders produced by spray pyrolysis using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observation, specific surface area (Brunauer-Emett-Teller), and particle size distribution measurements shows that the resultant large particles are loose agglomerates consisting of many small particles. However, the sintered tiny particles can form hard agglomerates, and the particle size increases remarkably. The structures of the powders before and after sintering were identified by x-ray diffraction (XRD). The study of the electrical property of the powder shows that the powder is a metallic conductor. In a reducing atmosphere, the powder can be decomposed. When the powder is cofired with yttria-stabilized zirconia 5% (YSZ) powder at 1200 °C for 5 h, no new phase is produced, and the powder remains a single provskite hexagonal-rhombohedral structure.     

Effect of surface free energy on the adhesion of biofouling and crystalline fouling

Pipelines and heat exchangers using seawater as coolant suffer from biofouling. Biofouling not only reduces heat transfer performance significantly, but also causes considerable pressure drop, calling for higher pumping requirements. It would be much more desirable if surfaces with an inherently lower stickability for biofouling could be developed. In this paper, a cost-effective autocatalytic graded Ni-Cu-P-PTFE composite coating with corrosion-resistant properties was applied to reduce biofouling formation. The experimental results showed that the surface free energy of the Ni-Cu-P-PTFE coatings, which were altered by changing the PTFE content in the coatings, had a significant influence on the adhesion of microbial and mineral deposits. The Ni-Cu-P-PTFE coatings with defined surface free energy reduced the adhesion of these deposits significantly. The anti-bacterial mechanism of the composite coatings was explained with the extended DLVO theory.     

无芯胶管的研制、工艺现状和发展建议

20世纪60年代初,我国胶管领域自主开发创新研制了无芯胶管制造技术,并且形成定型技术,一直沿用至今,笔者参与、见证了该产品从试验到投产的全过程。本文对该产品的工艺进行了新旧对比,提出了今后发展的建议。