Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Decomposed-distance weighted optimal transport for unsupervised domain adaptation

Applied Intelligence - Unsupervised Domain Adaptation (UDA) aims to transfer knowledge from a label-rich source domain to an unlabeled target domain with a different but related distribution....     

基于CORBA和TLl的STP网元集中管理系统实现

设计了STP网元集中管理系统,阐述了该系统的体系结构和各模块的功能以及各模块间的通信方式.通过使用CORBA构建技术、IDL接口描述语言以及文本描述语言TLl,使得系统具有灵活性、可维护性和可扩展性的特点.该系统的实现,使得对信令网中的STP设备进行集中管理和统一维护成为可能,为进一步对信令网的检测和历史数据的采集分析提供了基础.     

A hybrid data-fusion system using modal data and probabilistic neural network for damage detection

This paper addresses a novel hybrid data-fusion system for damage detection by integrating the data fusion technique, probabilistic neural network (PNN) models and measured modal data. The hybrid system proposed consists of three models, i.e. a feature-level fusion model, a decision-level fusion model and a single PNN classifier model without data fusion. Underlying this system is the idea that we can choose any of these models for damage detection under different circumstances, i.e. the feature-level model is preferable to other models when enormous data are made available through multi-sensors, whereas the confidence level for each of multi-sensors must be determined (as a prerequisite) before the adoption of the decision-level model, and lastly, the single model is applicable only when data collected is somehow limited as in the cases when few sensors have been installed or are known to be functioning properly. The hybrid system is suitable for damage detection and identification of a complex structure, especially when a huge volume of measured data, often with uncertainties, are involved, such as the data available from a large-scale structural health monitoring system. The numerical simulations conducted by applying the proposed system to detect both single- and multi-damage patterns of a 7-storey steel frame show that the hybrid data-fusion system cannot only reliably identify damage with different noise levels, but also have excellent anti-noise capability and robustness.     

Construction of 1-Resilient Boolean Functions with Optimal Algebraic Immunity and Good Nonlinearity

This paper presents a construction for a class of 1-resilient functions with optimal algebraic immunity on an even number of variables. The construction is based on the concatenation of two balanced functions in associative classes. For some n, a part of 1-resilient functions with maximum algebraic immunity constructed in the paper can achieve almost optimal nonlinearity. Apart from their high nonlinearity, the functions reach Siegenthaler's upper bound of algebraic degree. Also a class of 1-resilient functions on any number n > 2 of variables with at least sub-optimal algebraic immunity is provided.     

合成氨工艺参数优化技术开发及应用

以氨净值为响应值,影响响应值的17个过程参数为变量,经逐步回归选入触媒温度左3,触媒温度左4,循环CH_4%,H/N,NH_3%(进口)5个过程参数建立预测方程,并根据该方程对响应值的拟合结果和误差分布对样本进行分类。在此基础上,采取图形显示技术和统计分析的方法对分类样本集的过程参数进行比对分析,由此获取优类信息制订优化的工艺参数方案,经仿真验证后用于指导合成氨装置的生产试验。试验结果与试验前的对照期比较,氨净值均值由13.86提高到14.54,吨氨气耗减少15.9887m~3,吨氨电耗减少15.8kWh,节能效益十分明显     

一种中文文档的非受限无词典抽词方法

本文提出了一种非受限无词典抽词模型,该模型通过自增长算法获取中文文档中的汉字结合模式,并引入支持度、置信度等概念来筛选词条。实验表明:在无需词典支持和利用语料库学习的前提下,该算法能够快速、准确地抽取中文文档中的中、高频词条。适于对词条频度敏感,而又对计算速度要求很高的中文信息处理应用,例如实时文档自动分类系统。     

Visualizing multiwavelength astrophysical data

With recent advances in the measurement technology for allsky astrophysical imaging, our view of the sky is no longer limited to the tiny visible spectral range over the 2D Celestial sphere. We now can access a third dimension corresponding to a broad electromagnetic spectrum with a wide range of allsky surveys; these surveys span frequency bands including long wavelength radio, microwaves, very short X-rays, and gamma rays. These advances motivate us to study and examine multiwavelength visualization techniques to maximize our capabilities to visualize and exploit these informative image data sets. In this work, we begin with the processing of the data themselves, uniformizing the representations and units of raw data obtained from varied detector sources. Then we apply tools to map, convert, color-code, and format the multiwavelength data in forms useful for applications. We explore different visual representations for displaying the data, including such methods as textured image stacks, the horseshoe representation, and GPU-based volume visualization. A family of visual tools and analysis methods is introduced to explore the data, including interactive data mapping on the graphics processing unit (GPU), the mini-map explorer, and GPU-based interactive feature analysis.