Estimation of reliability of stress-strength model with non-identical component strengths

An attempt has been made in this paper to estimate the reliability of an s-out-of-k system with non-identical component strengths when component strengths follow an exponential distribution. A further assumption is made that all the components are subjected to a common random stress which also follow an exponential distribution. Bayes and maximum likelihood estimators of such system reliability are considered. A Bayes estimate is obtained by using Lindley's approximation. Comparisons are made on the basis of efficiency and Pitman nearness probability through a Monte-Carlo study.     

Exergy analysis of the active solar distillation systems integrated with solar ponds

Active solar distillation system integrated with solar pond is the green energy system for desalination without negative environmental impact. This clean technology has potential to contribute a lot to water security, sustainable development, and world stability. In this article, results of the energy as well as exergy analysis performed on this novel system integrated with solar pond are presented. This theoretical analysis is carried out in the climatic conditions of New Delhi (India) during a typical summer day. The model and procedures can be helpful in the design, and performance investigation of the actual system anywhere in the world. The daily productivity, energy, and exergy efficiency of the passive solar still are found to be 5 L/m², 38.63 %, and 2.71 %, respectively, corresponding to a sum total of 24.436 MJ/m² day solar energy input in passive mode. With the integration of solar pond in the active solar still, the daily productivity, energy, and exergy efficiency rises to about 9.5 L/m², 46 %, and 14.81 % respectively, for thermal energy input from 100 to 500 W/m² during off-sunshine hours. The further improvement in the performance of the same system is observed if the thermal energy is supplied continuously (24 h) to the solar still in addition to incident solar radiation. The proposed system will meet the demand of freshwater in both rural and urban areas and help in reducing the load of CO₂ emission on the environment, saving high grade energy consumed for desalination through conventional devices and technologies.     

Surface functionalization of PLGA nanoparticles by non-covalent insertion of a homo-bifunctional spacer for active targeting in cancer therapy

This work reports the surface functionalization of polymeric PLGA nanoparticles by non-covalent insertion of a homo-bifunctional chemical crosslinker, bis(sulfosuccinimidyl) suberate (BS3) for targeted cancer therapy. We dissolved BS3 in aqueous solution of PVA during formulation of nanoparticles by a modified solid/oil/water emulsion solvent evaporation method. The non-covalent insertion of BS3 was confirmed by Fourier transform infrared (FTIR) spectroscopy. Curcumin and annexin A2 were used as a model drug and a cell specific target, respectively. Nanoparticles were characterized for particle size, zeta potential and surface morphology. The qualitative assessment of antibody attachment was performed by transmission electron microscopy (TEM) as well as confocal microscopy. The optimized formulation showed antibody attachment of 86%. However, antibody attachment was abolished upon blocking the functional groups of BS3. The availability of functional antibodies was evaluated by the presence of a light chain fraction after gel electrophoresis. We further evaluated the in vitro release kinetics of curcumin from antibody coated and uncoated nanoparticles. The release of curcumin is enhanced upon antibody attachment and followed an anomalous release pattern. We also observed that the cellular uptake of nanoparticles was significantly higher in annexin A2 positive cells than in negative cells. Therefore, these results demonstrate the potential use of this method for functionalization as well as to deliver chemotherapeutic agents for treating cancer.     

Microstructures and mechanical properties of boride-dispersed precipitation-hardening stainless steels produced by RST

Two commercial precipitation-hardening (PH) stainless steels were modified with 2.64 to 2.86 wt% Ti and 1.2 to 1.3 wt% B via rapid solidification technology (RST) and powder metallurgy (PM). The resulting alloys exhibited improved tensile and yield strengths over their commercial PH stainless steel counterparts at room and elevated temperatures. Ductility improvements at elevated temperatures were also observed. The improved mechanical properties were due to extremely fine microstructures stabilized by a fine dispersion of boride phases.     

The effect of curcumin on human B-cell immortalization by Epstein-Barr virus

Cyclosporine is a commonly used immunosuppressant in solid-organ transplantation. It is, however, associated with an increased incidence of Epstein-Barr virus (EBV)induced post-transplant lymphoproliferative disorder (PTLD). In this study, human B lymphocytes isolated from healthy volunteers were immortalized in vitro with EBV. The effect of oxidative stress mediated by cyclosporine A or hydrogen peroxide on in vitro B cell immortalization was studied by coculturing immortalized B cells with cyclosporine A and hydrogen peroxide. Curcumin, a phenolic extract of the spice turmeric, was then used to observe its effect on this process. We found that in vitro B-cell immortalization with EBV was promoted by the oxidative stress induced by cyclosporine A and hydrogen peroxide, with the maximum effect seen at concentrations of 500 ng/ml and 100 microM, respectively. Curcumin blocked the B-cell immortalization in a dose-dependent fashion with nearly complete inhibition at 20 microM. We conclude that, because both hydrogen peroxide and cyclosporine A strongly promote in vitro B-cell immortalization with EBV (the putative process responsible for PTLD) and curcumin, an extract of a common spice is an effective inhibitor of this process; curcumin may be an effective adjunct in the prevention of PTLD in the patients undergoing therapy with cyclosporine A.     

Matching and Interpolation of Shapes using Unions of Circles

While the notion of shape of an object is very intuitive, its precise definition is very elusive, and defining a useful metric for the shape distance between objects is a difficult endeavor. At the same time many successful techniques have been developed which interpolate between two objects, so in essence interpolate between shapes. W e present here work which uses a representation of objects as union of circles to define a distance between two objects and to base a method to interpolate between the two. This method can be used in a totally automatic fashion (that is, without any user intervention), or users can guide a pre-registration phase as well as a segmentation phase, after which the matched segments are interpolated pair-wise. The union of circles representation of the two objects is obtained from the Delaunay triangulation of their boundary points. The circles can be simplified to obtain smaller data sets. The circles are then optimally matched according to a distance metric between circles which is a function of their position, size, and feature, that is, a local configuration of circles. The interpolation between the two objects is then obtained by interpolating between the matched pairs of circles (the interpolations can be affine or non -affine). Examples with simple and more complex objects show how the technique can give results which correspond closely to the human notion of shape interpolation. The interpolations shown include some between a calf and a cow and between a cow and a giraffe. The examples given are in two dimensions, but all the steps except the segmentation have been implemented as well for three dimensional objects. W e also show the results of computation of distances between the objects used in our examples.     

Nonlinear instabilities in TCP-RED

This work develops a discrete-time dynamical feedback system model for a simplified TCP network with RED control and provides a nonlinear analysis that can help in understanding observed parametric sensitivities. The model describes network dynamics over large parameter variations. The dynamical model is used to analyze the TCP-RED operating point and its stability with respect to various RED controller and system parameters. Bifurcations are shown to occur as system parameters are varied. These bifurcations, which involve the emergence of oscillatory and/or chaotic behavior, shed light on the parametric sensitivity observed in practice. The bifurcations arise due to the presence of a nonlinearity in the TCP throughput characteristic as a function of drop probability at the gateway. Among the bifurcations observed in the system are period doubling and border collision bifurcations. The bifurcations are studied analytically, numerically, and experimentally.     

Liver transplantation for hepatocellular carcinoma

Liver transplantation (LT) for hepatocellular carcinoma (HCC) has been controversial, however, with increasing experience the results of the procedure in these patients have improved. Earlier reports of poor result may have been secondary to advanced tumor and poor patient selection. Careful patient selection and preoperative assessment of tumor characteristic is essential before offering LT to these patients. Results of LT in carefully selected cases may be similar to patients receiving LT for other reasons. In cirrhotic patients LT may offer a better long-term survival than liver resection.     

Studies on the reduction of nitrobenzene to aniline catalysed by pd(acac)2-pyridine system

The complex, bis(acetylacetonato)palladium(II) in pyridine, is used as a homogeneous catalyst for the conversion of nitrobenzene to aniline. From a study of various operational parameters the optimum reduction was found to occur at 1 atm pressure and at room temperature in petroleum ether (b.p. 100–120°C) solvent, yielding 90% of aniline on input nitrobenzene basis. The complex [Pd¹¹(acac)H(C₆H₅NO₂)Py] was isolated under similar experimental conditions and was characterised by elemental analysis, magnetic, thermal and spectral studies. Formation of a phenylnitrene metal complex has been suggested as a hypothetical intermediate in the reduction process.