Fabrication of a Continuously Oriented Porous Al2O3 Body and Its In Vitro Study

Continuously oriented porous Al₂O₃ bodies were fabricated by a multi-pass extrusion process using C powders and ethylene vinyl acetate as an agent for pore forming and as a binder, respectively. The main pore size can be easily controlled by increasing the number of extrusion passes. The edges of the pore frame showed a rough surface having many fine pores about 0.2–1 μm in size. In the continuously porous Al₂O₃ bodies having 150 μm pore size, the values of the relative density and bending strength were about 63% and 90 MPa, respectively. These values were higher than those of an Al₂O₃ porous body made by a common process. From the in vitro study using human osteoblast-like MG-63 cells, it was confirmed that the cells grew well and adhered to the top surface and inside pores, as well as the outside wall of the continuously porous Al₂O₃ body. Without the directionality, the cells showed some spindle-shaped, three-dimensional, and network-type structures.     

Spectral analysis of malfunction mode in endmilling

For the investigation of the chatter modes, the power spectrum of the parametric time series model was adopted and analyzed at several mixed conditions of different revolution. This paper describes a methodology for an application of several time series such asAR (forward-backward, burg, least square, Yule Walker, geometric lattice, instrumental variable),ARX (least square, instrumental variable),ARMAX, ARMA, Box Jenkins, Output Error. To estimate the chatter mode using their spectral analysis their results were compared with one another. As a result, it was proven that several time series methods can be used for chatter mode estimation. Among them, theARX, ARMAX and instrumental variable methods (iv4) are more desirable and reliable than the other algorithm for the exact calculation of the chatter mode in endmilling. Among three cutting forces, the z direction cutting force,Fz, has more powerful characteristics of chatter occurring than the cutting forces,Fx andFy, in the sense that weak mode is calculated exactly and there is no shifted or pseudo mode in the estimated power spectra of endmilling forces.     

Can an immunologically, nonreactive potential allograft recipient undergo transplantation without a donor-specific crossmatch?

Performance of the pretransplant crossmatch requires 4 or more hours . Delays in the crossmatch might alter operating room availability and thereby increase donor organ cold ischemia time that might then result in increased risk of delayed graft function. To avoid these problems, recipients could be identified who would be expected to display negative donor crossmatches and who could be transplanted with a concurrent or retrospective rather than a pretransplant crossmatch. We, therefore, evaluated the percent reactive antibodies and donor IgG-antihuman globulin (AHG) crossmatch results of 1165 sera from 220 potential allograft recipients. Twenty-five (11%) of 220 recipients consistently displayed a 0% PRA and, with only one exception, their sera (n= 156) tested IgG-AHG crossmatch-negative against potential cadaveric donors (a 0.6% IgG-AHG positive crossmatch risk). These data suggest that the timing of the pretransplant serum crossmatch could be altered for a highly selected group of immunologically nonreactive recipients.     

The transepicondylar axis approximates the optimal flexion axis of the knee

The traditional understanding of knee kinematics holds that no single fixed axis of rotation exists in the knee. In contrast, a recent hypothesis suggests that knee kinematics are better described simply as two simultaneous rotations occurring about fixed axes. Knee flexion and extension occurs about an optimal flexion axis fixed in the femur, whereas tibial internal and external rotations occur about a longitudinal rotation axis fixed in the tibia. No other translations or rotations exist. This hypothesis has been tested. Tibiofemoral kinematics were measured for 15 cadaveric knees undergoing a realistic loadbearing activity (simulated squatting). An optimization technique was used to identify the locations of the optimal flexion and longitudinal rotation axes such that simultaneous rotations about them could best represent the measured kinematics. The optimal flexion axis was compared with the transepicondylar axis defined by bony landmarks. The longitudinal rotation axis was found to pass through the medial joint compartment. The optimal flexion axis passed through the centers of the posterior femoral condyles. No significant difference was found between the optimal flexion and transepicondylar axes. To an average accuracy of better than 3.4 mm in translation, and 2.9 degrees in orientation, knee kinematics were represented successfully by simple rotations about the optimal flexion and longitudinal rotation axes. The optimal flexion axis is fixed in the femur and can be considered the true flexion axis of the knee. The transepicondylar axis axis, which is identified easily by palpation, closely approximates the optimal flexion axis.     

Zero-voltage and zero-current-switching full bridge PWM converterfor high-power applications

A novel zero-voltage and zero-current-switching (ZVZCS) full-bridge (FB) pulse-width modulated (PWM) converter is proposed. The new converter overcomes the limitations of the zero-voltage-switching (ZVS)-FB-PWM converter, such as high circulating energy, loss of duty cycle, and limited ZVS load range for the lagging-leg switches. By using the DC blocking capacitor and adding a saturable inductor, the primary current during the freewheeling period is reduced to zero, allowing the lagging-leg switches to be operated with zero-current-switching (ZCS). Meanwhile, the leading-leg switches are still operated with ZVS. The new converter is attractive for high-voltage (400-800 V), high-power (2-10 kW) applications where IGBTs are predominantly used as the power switches. The principle of operation, features, and design considerations of the new converter are described and verified on a 2-kW, 100-kHz, IGBT-based experimental circuit     

Kinetics of copper drift in PECVD dielectrics

We quantified the drift of Cu ions into various PECVD dielectrics by measuring shifts in capacitance-voltage behavior after subjecting Cu-gate MOS capacitors to bias-temperature stress. At a field of 1.0 MV/cm and temperature of 100°C, Cu ions drift readily into PECVD oxide with a projected accumulation of 2.7×10¹³ ions/cm ² after 10 years. However, in PECVD oxynitride, the projected accumulation under the same conditions is only 2.3×10¹⁰ ions/cm². These findings demonstrate the necessity of integrating drift barriers, such as PECVD oxynitride layers, in Cu interconnection systems to ensure threshold stability of parasitic field n-MOS devices     

Paths across generations: academic competence and aggressive behaviors in young mothers and their children

This research compared the social and cognitive development of young mothers when they were children with the social and cognitive development of their offspring. Intergenerational development was investigated over a 17-year period for 57 women who had been studied longitudinally from childhood to adulthood and who became young mothers (R. B. Cairns & B. D. Cairns, 1994). The children of these women, in turn, were followed prospectively from 1 to 2 years old through the early school years. The academic competence of mothers when they were children was significantly linked to the academic competence of their children at school age. In contrast, the across-generation correlations between measures of aggressive behavior of the mothers when they were children and measures of aggressive behavior of their children in early school grades were modest and unreliable. Certain within-generation continuities were observed in both cognitive and aggressive development.     

Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice

BACKGROUND: Receptor-mediated activation of myocardial Gq signaling is postulated as a biochemical mechanism transducing pressure-overload hypertrophy. The specific effects of Gq activation on the functional and morphological adaptations to pressure overload are not known. METHODS AND RESULTS: To determine the effects of intrinsic myocyte G alpha q signaling on the left ventricular hypertrophic response to experimental pressure overload, transgenic mice overexpressing G alpha q specifically in the heart (G alpha q-25) and nontransgenic siblings underwent microsurgical creation of transverse aortic coarctation and the morphometric, functional, and molecular characteristics of these pressure-overloaded hearts were compared at increasing times after surgery. Before aortic banding, isolated G alpha q-25 ventricular myocytes exhibited contractile depression (depressed +dl/dt and -dl/dt) and G alpha q-25 hearts showed a pattern of fetal gene expression similar to the known characteristics of nontransgenic pressure-overloaded mice. Three weeks after transverse aortic banding, G alpha q-25 left ventricles hypertrophied to a similar extent (approximately 30% increase) as nontransgenic mice. However, whereas nontransgenic mice exhibited concentric left ventricular remodeling with maintained ejection performance (compensated hypertrophy), G alpha q-25 left ventricles developed eccentric hypertrophy and ejection performance deteriorated, ultimately resulting in left heart failure (decompensated hypertrophy). The signature hypertrophy-associated progress of fetal cardiac gene expression observed at baseline in G alpha q-25 developed after aortic banding of nontransgenic mice but did not significantly change in aortic-banded G alpha q-25 mice. CONCLUSIONS: Intrinsic cardiac myocyte G alpha q activation stimulates fetal gene expression and depresses cardiac myocyte contractility. Superimposition of the hemodynamic stress of pressure overload on G alpha q overexpression stimulates a maladaptive form of eccentric hypertrophy that leads to rapid functional decompensation. Therefore G alpha q-stimulated cardiac hypertrophy is functionally deleterious and compromises the ability of the heart to adapt to increased mechanical load. This finding supports a reevaluation of accepted concepts regarding the mechanisms for compensation and decompensation in pressure-overload hypertrophy.     

Whole-body [18F]FDG PET in the management of metastatic brain tumours

BACKGROUND: To determine its roles in the diagnosis and the systemic evaluation of metastatic brain tumours, whole-body positron emission tomography (PET) using [18F]FDG was performed in 20 consecutive patients. METHODS: All patients were thought to be suffering or needing to be differentiated from metastatic brain tumours. Nine patients had multiple brain lesions; six were older and showed a rim-enhancing lesion with surrounding oedema; seven had homogeneously enhancing periventricular lesion(s) on computed tomography (CT) and/or magnetic resonance (MR) imaging, thought to be central nervous system lymphomas. Two patients had skull mass(es) and two patients had a solid mass suspected to be, respectively, a haemorrhagic metastasis and a metastatic malignant melanoma. All of them received whole-body [18F]FDG PET and conventional systemic work-up for metastasis in order to compare the results of the two methods. RESULTS: Metastatic brain tumours were diagnosed on whole-body [18F]FDG PET in eleven patients who had extracranial and intracranial hypermetabolic lesions. In nine of these, a conventional work-up also detected primary lesions which on whole-body [18F]FDG PET were seen to be hypermetabolic foci. Systemic lymph node metastases were detected by whole-body [18F]FDG PET only in two patients and histological diagnosis was possible by biopsy of lymph nodes rather than of brain lesions. In the remaining nine patients who had only intracranial hypermetabolic foci, histological diagnosis was made by craniotomy or stereotactic biopsy. It was confirmed that seven of nine patients were suffering from a primary brain tumour and two from metastatic carcinoma. None of the nine showed evidence of systemic cancer on conventional work-up. Histological diagnoses of the primary brain tumours were four cases of primary central nervous system lymphoma and one each of multifocal glioblastoma, Ewing's sarcoma, and cavernous angioma. Patients felt no discomfort during the whole-body [18F]FDG PET procedure and there were no complications. The false negative rate in [18F]FDG PET and in conventional work-up was 15.4% and 30.7% respectively. There were no false positives on either [18F]FDG PET or conventional work-up. CONCLUSION: It is suggested that whole-body [18F]FDG PET is a safe, reliable, and convenient method for the diagnosis and systemic evaluation of patients thought to be suffering or needing to be differentiated from a metastatic brain tumour.