Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study

Normal women produce small amounts of active androgens. When androgen levels are elevated, such as for example in the polycystic ovary syndrome, this is followed by the development of male physical characteristics and muscle mass, structure and function as well as android adipose tissue distribution and function. Psychological features and stress reactions also seem similar to those of men. Such women have an increased risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular disease. Recent data have shown that these physical, and psychological characteristics, as well as risk of ill health, are also found in the population of women selected at random. Women in the lowest quintiles of levels of sex-hormone-binding globulin--an indicator inversely related to active androgens--are at risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular mortality. The mechanism probably includes muscular insulin resistance, following a relative androgen excess. It is thus apparent that androgens, even within the highest levels of the nonselected population of women, are powerful predictors of serious disease development. The population at risk might be as large as about 20% of middle-aged women. This is an area of female disease risk which requires more attention in screening and intervention procedures.     

Stimulus and temporal cues in classical conditioning.

In 2 experiments, separate groups of rats were given stimulus conditioning, temporal conditioning, untreated control and (in Experiment 2) learned irrelevance control procedures followed by a compound with both stimulus and temporal cues. Stimulus conditioning consisted of a random 15-s duration conditioned stimulus (CS) followed by food; temporal conditioning consisted of food–food intervals of fixed 90 s (Experiment 1) or fixed 75?+?random 15 s (Experiment 2). The stimulus group abruptly increased responding after CS onset, and the temporal group gradually increased responding over the food–food interval. When the food–food interval was fixed 90 s, the temporal cue exerted stronger control in the compound, whereas when the food–food interval was fixed 75?+?random 15 s, the stimulus cue exerted stronger control. The strength of conditioning, temporal gradients of responding, and cue competition effects appear to reflect simultaneous timing of multiple intervals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nonmonotonic behavior of the maximum collapse pressure in a cavitation bubble

Calculations which are relevant to the determination of the maximum collapse pressure generated inside a microbubble as a function of peak pressure in the driving ultrasonic pulse are presented. It is found that above the threshold for transient cavitation, the maximum collapse pressure has a nonmonotonic variation. This result is explained on the basis of phase differences between the external applied acoustic pulse and the resulting bubble response.     

A bilevel mixed-integer program for critical infrastructure protection planning

Vulnerability to sudden service disruptions due to deliberate sabotage and terrorist attacks is one of the major threats of today. In this paper, we present a bilevel formulation of the r-interdiction median problem with fortification (RIMF). RIMF identifies the most cost-effective way of allocating protective resources among the facilities of an existing but vulnerable system so that the impact of the most disruptive attack to r unprotected facilities is minimized. The model is based upon the classical p-median location model and assumes that the efficiency of the system is measured in terms of accessibility or service provision costs. In the bilevel formulation, the top level problem involves the decisions about which facilities to fortify in order to minimize the worst-case efficiency reduction due to the loss of unprotected facilities. Worst-case scenario losses are modeled in the lower-level interdiction problem. We solve the bilevel problem through an implicit enumeration (IE) algorithm, which relies on the efficient solution of the lower-level interdiction problem. Extensive computational results are reported, including comparisons with earlier results obtained by a single-level approach to the problem.     

A mode control model of counting and timing processes.

In Exp I, 10 male albino Norway rats initially learned a discrimination between a 2-cycle auditory signal of 2-sec duration and an 8-cycle auditory signal of 8-sec duration. In a number discrimination test, the number of cycles was varied, and the signal duration was held constant at an intermediate value. In a duration discrimination test, the signal duration was varied, and the number of cycles was held constant at an intermediate value. Ss were equally sensitive to a 4:1 ratio of counts (with duration controlled) and a 4:1 ratio of times (with number controlled). The point of subjective equality for the psychophysical functions that related response classification to signal value was near the geometric mean of the extreme values for both number and duration discriminations. Exp II demonstrated that methamphetamine (1.5 mg/kg, ip) shifted the psychophysical functions for both number and duration leftward by approximately 10%. Exp III demonstrated that the magnitude of cross-modal transfer from auditory to cutaneous signals was similar for number and duration. In Exp IV (6 Ss), the mapping of number onto duration demonstrated that a count was approximately equal to 200 msec. The psychophysical functions for number and duration were fit with a scalar expectancy model with the same parameter values for each attribute. It is concluded that the same internal mechanism is used for counting and timing. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

“When Is Short,Sweet?” Selection Uncertainty and Online Review Presentations

Online customer reviews are an important part of e-commerce product selection. When used effectively, online reviews may reduce the uncertainty inherent in making product selection decisions online, but how best to deal with thousands of online customer reviews? Past research considers online review summarization, where reviews are reduced to numeric ratings, key phrases, keywords or product characteristics. However, in their original form, online reviews contain the carefully crafted narratives of past customers, elements of which may not be amenable to summarization. In this research, we present findings of a laboratory experiment which examines the impact of review summarization when evaluating different types of products online. Key findings include evidence that perceptions of product selection uncertainty depend on online review presentation format and the category of the product under consideration. Additionally, the study provides evidence that the e-commerce retailers may benefit from varying online review presentations across specific types of products.     

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

Exposure to ambient ozone (O3) is associated with increased exacerbations of asthma. We sought to determine whether mast cell degranulation is induced by in vivo exposure to O3 in mice and whether mast cells play an essential role in the development of pulmonary pathophysiological alterations induced by O3. For this we exposed mast cell-deficient WBB6F1-kitW/kitW-v (kitW/kitW-v) mice and the congenic normal WBB6F1 (+/+) mice to air or to 1 or 3 parts/million O3 for 4 h and studied them at different intervals from 4 to 72 h later. We found evidence of O3-induced cutaneous, as well as bronchial, mast cell degranulation. Polymorphonuclear cell influx into the pulmonary parenchyma was observed after exposure to 1 part/milllion O3 only in mice that possessed mast cells. Airway hyperresponsiveness to intravenous methacholine measured in vivo under pentobarbital anesthesia was observed in both kitW/kitW-v and +/+ mice after exposure to O3. Thus, although mast cells are activated in vivo by O3 and participate in O3-induced polymorphonuclear cell infiltration into the pulmonary parenchyma, they do not participate detectably in the development of O3-induced airway hyperresponsiveness in mice.     

Personality research in a non-Western culture: The Philippines.

Here I review personality research in one non-Western culture, the Philippines. Reports from diverse cultures remind one that personality findings reflect the cultural setting from which they emerge, lead to "cross-indigenous" comparisons between alternative cultural perspectives, and suggest hypotheses about cultural generality versus uniqueness. I illustrate the impact of cultural context on topics studied; on the applicability of concepts, methods, and measures; and on the practice of psychology by using the Philippine case. I also discuss issues regarding the cultural universality versus uniqueness of Filipino personality concepts, current efforts toward developing an indigenous Philippine psychology, and the language issue. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of a strong magnetic field on the damping of second sound in dilute3He-4He mixtures below 100 mK

We have measured the increase in damping of second sound in 0.1% and 0.05%³He-⁴He solutions upon application of a magnetic field of 10 T. The increase is caused by changes in the thermal conductivity and viscosity of the mixture as the system becomes spin polarized. We show how to fit the data for the viscosity in zero-field to obtain an estimate of the interaction between the³He quasiparticles. It is then possible to predict the viscosity in a field of 10 T using the calculation of Hampson et al. The data agree with the theory to within 2%.