Ultrasound findings in hepatitis

A retrospective study of ultrasound images of the liver in patients with hepatitis was undertaken. Two distinct ultrasound patterns were detected. In acute hepatitis, the predominant findings were accentuated brightness and more extensive demonstration of the portal vein radicle walls and overall decreased echogenicity of the liver. Chronic hepatitis primarily revealed decreased brightness and number of portal vein radicle walls and verall increased liver echogenicity. In addition, the pathological severity closely paralleled these ultrasound patterns. A prospective study confirmed the same acute hepatitis ultrasound findings with close correlation to the clinical severity. These distinct ultrasound patterns will help to evaluate patients with suspected acute and chronic hepatitis and more accurately define intrahepatic causes of jaundice.     

The comparative histopathology of primary and secondary lesions in murine salmonellosis

In a primary infection, Swiss-Webster mice were injected i.p. with 10(2) or 10(3) virulent Salmonella typhimurium. Multiple microscopic acute abscesses with predominantly polymorphonuclear leucocytes (PMNs) were seen in the liver and the spleen beginning on the 4th day after infection. By the 7th day, these lesions had become enlarged and were gradually transformed into granulomas with central necrosis and peripheral mononuclear cells. The animals usually died within 12 days with massive systemic infection and degeneration of the tissues. In contrast, it was necessary to inoculate 10(6) virulent salmonella i.v. into mice immunized with avirulent S. thphimurium in order to initiate microscopically observable lesions in the liver and the spleen. These secondary lesions were characterized by the early appearance of minute granulomas composed almost entirely of histiocytic cells. They remained small and isolated, usually without central necrosis. Subsequent regression of the lesions and regeneration of normal tissue occurred after the 2nd week following infection. The animals usually survived such a challenge infection.     

Pharmacokinetics and metabolic disposition of 14C-metronidazole-derived radioactivity in rat after intravenous and intravaginal administration

Urinary metabolites and the pharmacokinetics of radioactivity derived from 14C-metronidazole (14C-MTZ) were determined after intravenous (iv) or intravaginal (ivg) administration of 10 mg/kg to adult rats. Following iv or ivg administration, the disappearance of 14C from blood followed the kinetics of a two-compartment open-system model. The blood half-lives of 14C during the beta-phase were 10.9 +/- 1.6 and 13.6 +/- 4.2 hr, after iv and ivg administration, respectively. After ivg application, the MTZ-derived radioactivity was detected in tail blood at 5 min, peaked at 1 hr, declined rapidly to 6 hr and more slowly thereafter. The vaginal absorption half-life of 14C-MTZ was 0.28 +/- 0.09 hr. About 12% of the administered dose remained in the vagina after 1 hr and 1.5% after 24 hr. At 24 hr, the tissue distribution and concentration of 14C were similar in iv and ivg dosed rats, the highest 14C concentration being present in the kidneys and lowest in the fat. The percentages of the dose excreted in 24 hr in the urine and feces were 58 and 15 after iv administration, compared to 37 and 40 after the ivg route, respectively. Unchanged 14C-MTZ and five of its metabolites were detected in the urine irrespective of the route of administration. The results show that metronidazole is rapidly absorbed through the vaginal mucosa of the rat and the metabolism and excretion of this chemotherapeutic agent are influenced by the route of administration.     

Thyroid carcinoma after high-dose external radiotherapy for Hodgkin's disease: report of three cases

Three patients (two female and one male), who had received mantle irradiation for Hodgkin's disease eight, ten, and twelve years previously, developed papillary thyroid carcinoma. The radiation doses to the necks overlying the site of thyroid cancers were 3000, 4000, and 4100 rads, respectively. It has been stated that there is no risk of developing thyroid cancer with such high doses of external irradiation but apparently this complication will be encountered in a small number of patients.     

Hybridizing mixtures of experts with support vector machines: Investigation into nonlinear dynamic systems identification

Mixture of experts (ME) models comprise a family of modular neural network architectures aiming at distilling complex problems into simple subtasks. This is done by deploying a separate gating module for softly dividing the input space into overlapping regions to be each assigned to one or more expert networks. Conversely, support vector machines (SVMs) refer to kernel-based methods, neural-network-alike models that constitute an approximate implementation of the structural risk minimization principle. Such learning machines follow the simple, but powerful idea of nonlinearly mapping input data into high-dimensional feature spaces wherein a linear decision surface discriminating different regions is properly designed. In this work, we formally characterize and empirically evaluate a novel approach, named as Mixture of Support Vector Machine Experts (MSVME), whose main purpose is to combine the complementary properties of both SVM and ME models. In the formal characterization, an algorithm based on a maximum likelihood criterion is considered for the MSVME training, and we demonstrate that it is possible to train each expert based on an SVM perspective. Regarding the empirical evaluation, simulation results involving nonlinear dynamic system identification problems are reported, contrasting the performance shown by the MSVME approach with that exhibited by conventional SVM and ME models.     

Modified imperialist competitive algorithm based on attraction and repulsion concepts for reliability-redundancy optimization

System reliability analysis and optimization are important to efficiently utilize available resources and to develop an optimal system design architecture. System reliability optimization has been solved by using optimization techniques including meta-heuristics. Meanwhile, the development of meta-heuristics has been an active research field of the reliability optimization wherein the redundancy, the component reliability, or both are to be determined. In recent years, a broad class of stochastic meta-heuristics, such as simulated annealing, genetic algorithm, tabu search, ant colony, and particle swarm optimization paradigms, has been developed for reliability-redundancy optimization of systems. Recently, a new kind of evolutionary algorithm called Imperialist Competitive Algorithm (ICA) was proposed. The ICA is based on imperialistic competition where the populations are represented by countries, which are classified as imperialists or colonies. However, the trade-off between the exploration (i.e. the global search) and the exploitation (i.e. the local search) of the search space is critical to the success of the classical ICA approach. An improvement in the ICA by implementing an attraction and repulsion concept during the search for better solutions, the AR-ICA approach, is proposed in this paper. Simulations results demonstrates the AR-ICA is an efficient optimization technique, since it obtained promising solutions for the reliability redundancy allocation problem when compared with the previously best-known results of four different benchmarks for the reliability-redundancy allocation problem presented in the literature.     

Mental health and behavioral sciences: One federal agency's role in the behavioral sciences.

Presents a historical overview of the role of the National Institute of Mental Health in developing and using the behavioral sciences as the substantive base of its various programs of research, training and services. Major themes of research programs are illustrated with special reference to schizophrenia, brain-behavior relations, small-group interaction, collective behavior, and adaptation in stress. Training program development in the various mental health specialties is also described. Innovative models of interdisciplinary research training, involving the biological, psychological and social sciences are recommended to respond to complex research challenges in the mental health field. (16 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)