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21.
Colin Fyfe 《Data mining and knowledge discovery》2007,14(2):207-224
We review a new form of self-organizing map which is based on a nonlinear projection of latent points into data space, identical
to that performed in the Generative Topographic Mapping (GTM) [Bishop et al. (1997) Neurl Comput 10(1): 215–234]. But whereas
the GTM is an extension of a mixture of experts, our new model is an extension of a product of experts [Hinton (2000) Technical
report GCNU TR 2000-004, Gatsby Computational Neuroscience Unit, University College, London]. We show visualisation results
on some real data sets and compare with the GTM. We then introduce a second mapping based on harmonic averages and show that
it too creates a topographic mapping of the data. We compare these mappings on real and artificial data sets.
Responsible editor: Soumen Chakrabarti. 相似文献
22.
23.
The lipid composition of blubber, brain, muscle and heart from a Mediterranean monk sealMonachus monachus (an endangered species) were examined to allow comparisons with more common species of seals. Only neutral lipids (mainly
triacylglycerols) were detectable in the blubber lipids, whereas polar lipids predominated in the heart and in the brain.
Neutral and polar lipids comprised almost equal proportions in both liver and muscle. Choline glycerophospholipids (CGP) were
the major polar lipids, followed by ethanolamine glycerophospholipids (EGP) in the liver, heart and muscle. Cerebrosides accounted
for 28.8% of the brain lipids. All lipid classes of the liver contained high levels (31–47%) of polyunsaturated fatty acids
(PUFA), with the exception of phosphatidylserine. The total proportion of n−6 PUFA exceeded that of n−3 PUFA in all lipid
classes of the liver, due mainly to the high levels of 20∶4n−6. The highest level of 20∶4n−6 occurred in phosphatidylinositol,
where it comprised 32.4% of the total fatty acids. The CGP and EGP of the brain contained lower levels of PUFA than those
of the liver, muscle and heart. Alkenyl ethers accounted for 35.8% of the total long-chain moieties in brain EGP. The fatty
acid composition of blubber triacylglycerols differed from those of the lipid classes from other tissues in that it had a
very low ratio of n−6 to n−3 PUFA (0.3) as a result of a lower content of 20∶4n−6. 相似文献
24.
25.
The UK's vast marine energy resource is mostly located in remote areas west and north of Scotland, and transmission of this energy to the mainland will be required. This may be achieved by using this ‘stranded’ power to generate hydrogen electrolytically, which may in turn be stored or transported using sponge iron technology. This paper reviews the technology and research needed to bring such a process on stream. We propose utilising techniques that have been developed for the oxygen carriers used in chemical looping, and also those used in early processes for hydrogen generation in the chemical industry. We briefly outline the design requirements for an energy efficient sponge iron plant. It is shown that the iron sponge system presents better energy efficiencies than alternative forms of bulk storage such as liquid hydrogen, magnesium hydride slurry, some at least of the metal hydrides, or methylcyclohexane–toluene–hydrogen, provided that requirements can be met for particle durability and reactivity. 相似文献
26.
Johanna Bakker Colin F. Timberlake 《Journal of the science of food and agriculture》1985,36(12):1315-1324
The distribution of anthocyanins in methanolic skin extracts of 16 grape cultivars used for port wine production and grown at five sites in the Douro Valley in Northern Portugal has been assessed by high performance liquid chromatography. Results are confined to the seven most readily separated and identified anthocyanins and are expressed as percentages of their total (88–99% of the total integrated area). Anthocyanins based on malvidin (Mv) predominated. Of these, Mv 3-glucoside was the major pigment (33–60%), being exceeded by Mv 3-p-coumarylglucoside (2–51%) in only two cultivars; Mv 3-acetylglucoside (1–15%) was consistently the lowest. Peonidin 3-glucoside (1–27%) was prominent in four cultivars, but delphinidin 3-glucoside (1–11%), petunidin 3-glucoside (2–11%) and cyanidin 3-glucoside (trace-6%) were of low proportions throughout. The ratio Mv 3-acetylglucoside/total Mv glucosides appeared characteristic of cultivar, independent of site, and a useful aid to identification of grape cultivars. The coloured pulp of some cultivars contained peonidin 3-glucoside as a major component, present in greater proportions than in the skin; the percentage of Mv 3-p-coumarylglucoside was lower in pulp than in skin. The identities of six of the seven anthocyanins were confirmed by fast atom bombardment mass spectrometry and the structures of the Mv derivatives were determined by nuclear magnetic resonance. The formation of formyl and acetyl anthocyanin artefacts is described. 相似文献
27.
Hypoglycemia causes hyperphagia and weight gain, through unknown peripheral and central signals. We investigated the effect of hypoglycemia on NPY and leptin expression and the ability of leptin to inhibit hypoglycemia-induced hyperphagia. Acute hypoglycemia (60 U/kg SC insulin; n = 8) increased food intake (p < 0.01) compared with controls (n = 8). Insulin- and leptin-treated rats (300 microg/kg IP leptin; n = 8) had reduced hyperphagia (p < 0.05 vs. controls; p < 0.05 vs. insulin alone) and a 15% fall in NPY mRNA levels compared with controls (p < 0.01). Chronic hypoglycemia, (20-60 U/kg/day insulin; n = 8) increased food intake compared with vehicle-treated controls (p < 0.01). Leptin and insulin administration (300 microg/kg/day IP leptin; n = 8) reduced hyperphagia (p < 0.01 vs. controls, p < 0.05 vs. insulin alone), and NPY mRNA fell by 18% vs. controls (p < 0.01). We conclude that hypoglycemia-induced hyperphagia is not mediated by either a fall in leptin or an increase in hypothalamic NPY mRNA. Leptin can inhibit feeding in hyperphagic hypoglycemic rats, and this may partly be attributable to its inhibition of the NPY neurons. 相似文献
28.
Douglas A. Watkinson Colin Charles Eva C. Enders 《Journal of Great Lakes research》2021,47(3):583-591
Common carp feeding and spawning behaviours negatively impact the functioning of marsh ecosystems. In the Netley-Libau Marsh, situated on the southern end of Lake Winnipeg, water level regulations, nonpoint source nutrient pollution, and the non-native common carp are thought to be the main contributors to the degradation of the marsh habitat. Using acoustic telemetry, we analysed the movement rate, frequency and timing of suspected spawning migrations, spatial ecology, and aggregation of common carp in the Lake Winnipeg drainage over a three year time period. Common carp moved the farthest during the open water period when water temperature was >5 °C. Their annual migration into Netley-Libau Marsh was correlated to ordinal date. Common carp left the marsh in late spring/early summer, presumably feeding in Lake Winnipeg, before moving to overwintering sites situated in Traverse Bay and Lake Winnipeg, where they arrived typically by October and formed aggregations. These findings will inform habitat and fisheries managers in the effort to undertake evidence-based management actions. The predictability of the movements and the tendency for common carp to aggregate indicates that exclusion techniques and commercial fishing may represent viable management solutions. 相似文献
29.
Tyana A. Rudolfsen Doug A. Watkinson Colin Charles Colin Kovachik Eva C. Enders 《Journal of Great Lakes research》2021,47(3):635-647
Understanding relationships between freshwater fishes and habitat is critical for effective fisheries and habitat management. Habitat suitability indices (HSI) are commonly used to describe fish–habitat associations in rivers and other freshwater ecosystems. When applied to large lakes however, standard sampling procedures are inadequate because of larger sampling areas and an increased risk of fish collection bias through one-time observations. Here, we use lake bathymetry, substrate, and multiple fish telemetry detections collected from a systematically deployed receiver grid to develop HSI for four fish species (lake sturgeon, freshwater drum, common carp, and walleye) in Lake Winnipeg. Seasonal variations in habitat use based on water depth and substrate were observed in three of four species. Lake sturgeon remained in shallow locations with predominantly gravel substrate near the mouth of the Winnipeg River regardless of season. Freshwater drum persisted over fine substrate in both summer and winter but had a broader depth range in the summer compared to winter. Common carp shifted from mid-range depths and silt substrate in the summer to shallow depths and gravel substrate in the winter. Walleye showed an unchanging association to fine substrate but expanded from primarily mid-range depths in the summer to include shallower depths in the winter. These findings show how multiple telemetry detections per fish can be combined with hydroacoustic data to provide informative habitat associations for fishes in a large lacustrine ecosystem. 相似文献
30.
Ionic flow associated with neural activation of the brain produces a magnetic field, called the neuromagnetic field, that can be measured outside the head using a highly sensitive superconducting quantum interference device (SQUID)-based neuromagnetometer. Under certain conditions, the sources producing the neuromagnetic field can be localized from a sampling of the neuromagnetic field. Neuromagnetic measurements alone, however, do not contain sufficient information to visualize brain structure. Thus, it is necessary to combine neuromagnetic localization with an anatomical imaging technique such as magnetic resonance imaging (MRI) to visualize both function and anatomy in vivo. Using experimentally measured human neuromagnetic fields and magnetic resonance images, the authors have developed a technique to register accurately these two modalities and have applied the registration procedure to portray the spatiotemporal distribution of neural activity evoked by auditory stimulation. 相似文献