Probability Distribution Functions for Construction Simulation

The need for reliable simulation systems has been discussed and recognized by many researchers. At the same time researchers have recognized that the quality of a simulation model's results are strictly related to the quality of the input probability distribution functions. The data used in this research were acquired from the Atkinson-Washington-Zachry joint venture on the Eastside Reservoir Project in California. The data were analyzed using BestFit software to obtain the parameters of the theoretical distribution functions that best described the field data set. The research validated previous warnings about the influence of the class interval decision on the selection of a distribution function when the chi-square fitting test is utilized. A second issue of importance that was encountered was the reliability of goodness-of-fit tests when dealing with large data sets.     

Hazard assessment of edible oil refining: Formation of flammable mixtures in storage tanks

This work presents a methodology for the assessment of hazards due to the formation of flammable mixtures in edible oil refineries, with particular focus on storage tanks. Safety issues in these plants are due to the presence of residual volatile flammable solvents deriving from the extraction processes, which may accumulate in the storage tanks and generate flammable vapour mixtures. The methodology, based on the application of a thermodynamic model for the estimation of vapour phase composition in oil storage tanks as a function of operating conditions (i.e. temperature and residual solvent content), allows the identification of potential hazards due to formation of flammable mixtures inside the tanks. The model was first validated using available experimental data and then extended to case-studies representative of state-of-the-art industrial storage applications. The results of the case-studies were then used to calculate specific hazard indexes, providing a quick tool for preliminary assessment of hazards due to the formation of flammable mixtures in edible oil storage plants.     

SWTRACK: An intelligent model for cargo tracking based on off-the-shelf mobile devices

Logistics represent the biggest cost for transportation companies. Companies are investing in monitoring and tracking systems aiming at improving services, reducing costs and ensuring the safety in cargos transports. This article presents an intelligent model to obtain the position of vehicles, using off-the-shelf mobile devices named SWTRACK. The proposal allows distributors companies to track loads and to have real-time information about their whereabouts during a travel. SWTRACK presents an automatic travel management to initialize and finish travels without user interaction. Furthermore, it provides a mechanism to monitor detours in planned routes and to send alarms notification through mobile devices. To build that mechanism, we studied the Geofence concept and existing techniques to prepare two solutions based on continuous monitoring. Those solutions were compared and discussed. We also conducted a model evaluation using off-the-shelf mobile devices. Moreover, we provide an impact analysis regarding GPS precision and battery power consumption. In the end, we show that the proposed model generates a reliable system for tracking vehicles.     

Morphology and electrochemical activity of SOFC composite cathodes: II. Mathematical modelling

This paper presents a mathematical model of mass and charge transport and electrochemical reaction in porous composite cathodes for application in solid oxide fuel cells. The model describes a porous composite cathode as a continuum, and characterises charge and mass transfer and electrochemical kinetics using effective parameters (i.e. conductivity, diffusivity, exchange current) related to morphology and material properties by percolation theory. The model accounts for the distribution of morphological properties (i.e. porosity, tortuosity, density of contacts among particles) along cathode thickness, as experimentally observed on scanning electron microscope images of LSM/YSZ cathodes of varying thickness. This feature allows the model to reproduce the dependence of polarisation resistance on thickness, as determined by impedance spectroscopy on LSM/YSZ cathodes of varying thickness. Polarisation resistance in these cathodes is almost constant for thin cathodes (up to 10 μm thickness), it sharply decreases for intermediate thickness, to reach a minimum value for about 50 μm thickness, then it slightly increases in thicker cathodes.     

A comparison of the performance of lightweight glass containers manufactured by the P&B and B&B processes

The mechanical performance of lightweight glass packages produced by the NNPB (narrow neck press and blow) process was evaluated by comparison with the same glass packages (regular weight) produced by the conventional process (blow and blow). The temper number (annealing process evaluation), thickness distribution behaviour and mechanical performance (impact, vertical load and thermal shock strength) were analysed before and after line simulation, applied in optimized conditions in the laboratory. The performance of lightweight glass packages under transport simulation (truck envelope) in relation to the regular weight bottles was also evaluated. Both bottles presented residual stress values within the specified limits. The lightweight glass bottles had a more homogenous thickness distribution in comparison with the regular weight bottles and a better performance (about 33% improvement) in relation to the impact strength, especially in the heel, even when evaluated after line simulation. As to the vertical load strength, the lightweight glass bottle also indicated a superior performance to the regular weight bottle, both before and after line simulation. Both bottles withstood the temperature difference of 42°C that such packages are supposed to resist according to thermal shock specification. Due to the better thickness distribution of lightweight glass packages, they withstood a maximum temperature difference (progressive thermal shock) of 5–10°C higher than the regular weight bottles. No restrictions of the lightweight glass packages submitted to the transport simulation were found. Copyright © 2002 John Wiley & Sons, Ltd.     

Potential of mean force calculations on an L-type calcium channel model

To understand the mechanisms of Na⁺/Li⁺ permeation at submicromolarCa²⁺ concentrations, Na⁺/Li⁺ blocking at higher Ca²⁺ concentrations(10^-6–10^-4 M) and Ca²⁺ permeation at millimolar Ca²⁺ concentrations,we used our recently described L-type calcium channel model.For this purpose, we obtained potential of mean force (pmf)curves for the position change of one Na⁺ and one Ca²⁺ ion insidethe channel and for the position change of a second Ca²⁺ ionwhen the EEEE locus is coordinated to Ca²⁺. The pmf curves suggestthat (i) at submicromolar Ca²⁺ concentrations, because of thelow velocity of Ca²⁺ entry in the channel, monovalent ion fluxoccurs; (ii) at Ca²⁺ concentrations between 10^-6 and 10^-4 M,thermodynamic equilibrium between the channel and Ca²⁺ is achieved;as the coordination of Ca²⁺ with the locus is more favorablethan the coordination of Na⁺, the monovalent ion flux is blocked;and (iii) to put a second Ca²⁺ ion inside the channel at anappropriate rate, the Ca²⁺ concentration should reach millimolarlevels. Nevertheless, the entry of a second Ca²⁺ is thermodynamicallyunfavorable, indicating that the competition of two Ca²⁺ ionsfor the locus leads to Ca²⁺ permeation.     

Platform designer: An approach for modeling multiprocessor platforms based on SystemC

This paper[3.5pc] presents the Platform Designer (PD) framework, a set of SystemC based tools that provide support for modeling, simulation and analysis of multiprocessor SoC platforms (MPSoC), at different abstraction levels. PD provides mechanisms for interconnection specification, process synchronization and communication, thus allowing the modeling of a complete platform, in a unified environment. To do that it uses an extension of the ArchC ADL and acsys, a tool that enables the automatic generation of a SystemC simulator of the platform. The main advantages of this approach are twofold. First, designers have more flexibility since they can integrate and configure different processors to the platform, using a single environment. Second, it enables a faster design space exploration, given that it automatically generates SystemC simulators of whole platforms at distinct abstraction levels. A number of platform variations can be tried out with minor design changes, thus reducing design time. Experimental results show the suitability of the platform simulator for design space exploration. Real applications (with medium complexity) run in the platform in few minutes. Combined with the facility to generate platforms with minor changes, this feature allows an improvement of the design space exploration.     

Chitosan-gelatin/hydroxyapatite-based scaffold associated with mesenchymal stem cells differentiate into osteoblasts improves the surface of the bone lesion in mice C57BL/6J

Extensive injuries to bone tissue are still considered a significant clinical challenge; therefore, developing new bone tissue engineering (BTE) strategies is still necessary. This work aims to construct and characterize a chitosan-gelatin/hydroxyapatite-based (CG/H) scaffold to provide well-design support for mesenchymal stem cell (MSC) growth and differentiation to osteoblasts. First, the CG/H scaffolds are construct by freeze-drying. Then, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, x-ray diffraction, water uptake, and degradation profiles evaluate the material's surface. In addition, the CG/H morphological, biochemical, and MSC adhesion processes and growth behavior are also assess, indicating reasonable adhesion rates to the surface, low material cytotoxicity, and excellent alkaline phosphatase activity compared to control on the cellular framework. Based on these results, we obtain a highly biocompatible scaffold and that can support osteoblast differentiation. Finally, the in vivo studies demonstrate the CG/H scaffold with MSC adhere is capable of differentiating into osteoblasts, and the application of this scaffold is able to significantly enhance the closure of the bone lesion. Therefore, the CG/H scaffold has potential clinical application for bone regeneration.     

Relevance of the Exocyst in Arabidopsis exo70e2 Mutant for Cellular Homeostasis under Stress

Plants must adapt to cope with adverse environmental conditions that affect their growth and development. To overcome these constraints, they can alter their developmental patterns by modulating cellular processes and activating stress-responsive signals. Alongside the activation of the antioxidant (AOX) system, a high number of genes are expressed, and proteins must be distributed to the correct locations within the cell. The endomembrane system and associated vesicles thus play an important role. Several pathways have been associated with adverse environmental conditions, which is the case for the exocyst-positive organelle—EXPO. The present work, using Arabidopsis mutants with T-DNA insertions in the gene EXO70, essential for EXPO vesicles formation, was designed to characterise the anatomical (morphology and root length), biochemical (quantification of stress markers and antioxidant system components), and molecular responses (gene expression) to abiotic stresses (saline, drought, oxidative, and metal-induced toxicity). The results obtained showed that mutant plants behave differently from the wild type (WT) plants. Therefore, in the exo70 mutant, morphological changes were more noticeable in plants under stress, and the non-enzymatic component of the antioxidant system was activated, with no alterations to the enzymatic component. Furthermore, other defence strategies, such as autophagy, did not show important changes. These results confirmed the EXPO as an important structure for tolerance/adaptation to stress.