Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.     

Studies of aversive conditioning for alcoholics: A critical review of theory and research methodology.

Reviews studies of the applications of aversive conditioning procedures to alcoholics. The review is divided into sections on electrical and chemical aversive stimulation and is organized according to the level of research design used. While many positive outcomes are reported, inconsistent theoretical underpinnings of the research are also reported. The lack of systematic investigation of relationships between therapist, patient, and technique characteristics indicate the need for further investigation. The ethics of using the techniques reviewed with human Ss are discussed. (62 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fly's eye: a counting camera for thermal neutrons-some applications, problems, and prospects

An area detector for thermal neutrons based on image intensification techniques has been described. Some capabilities and limitations of the detection system have been discussed. Among the former are high spatial resolution, high instantaneous counting rate, electronic zoom, time-gating, and integration. The detector is limited in that the maximum counting rate for a resolution element is 60 regularly spaced counts per second. Also, the nonuniformity of response over the detector puts a limit on the useful size and necessitates point-by-point calibration. In addition, a higher efficiency for neutron detection would be desirable. Some typical applications of the system are crystal inspection, neutron magnetic diffraction topography, and searches for temperature-induced changes in diffraction patterns. The future application of solid-state television sensors and microchannel-plate intensifiers to improve the system were briefly mentioned.     

The Imbrication Model for the integration of social services in a community

An innovative model for organising social services in a community, the Imbrication Model, is contrasted with two traditional models, the Entrepreneurial and the Umbrella Agency. The structural characteristics and dynamics of the three models are illustrated with actual case histories. Imbrication Model calls for the interlocking of personnel from several agencies, with the purpose of redirecting the dysfunctional interagency rivalry prevalent in the traditional models. Imbrications at all organisational levels--Board of Directors, Administrators and Staff--facilitate adoption of the superordinate goal of providing clients with the best services available, regardless of which particular agency delivers the service. Few observers of the current social service scene would challenge the statement that needs for service are unlimited and resources limited. In the USA the imbalance between needs and resources persists despite a decade of massive governmental programmes intended to alleviate social ills. Recent substantial cutbacks in federal funds, moreover are not likely to improve the situation. The resource shortage involves more than a limitation of funds. Deliverers of service and competent programme administrators are also on critically short supply. These shortages are more often than not exacerbated by a chronic spirit of competition among agencies and programmes at the local level. Three organizational models for the delivery and administration of social services, two conventional and one of more recent date, are examined in this article. The innovative model, which has been named the Imbrication Model, explicitly calls for redirecting interagency rivalry and competition. Its ambitious goal is to integrate the efforts of those attempting to meet a community's social service needs.