Mathematical models for motile bacterial transport in cylindrical tubes

Mathematical models considering motile bacterial transport within a geometrically restrictive cylindrical tube were developed. Two macroscopic transport parameters, the random motility coefficient as a self-diffusion coefficient of the cell population and the chemotactic velocity as a chemical-induced velocity, were derived. The three-dimensional cell balance equation was reduced to forms similar to Segel's one-dimensional phenomenological cell balance equations with additional modifications for bacteria-wall interactions. Two conceptually different approaches accounting for such interactions were presented. The first approach parallels treatments in the gas kinetic theory by viewing bacterial interactions with walls as collisions and subsequent diffusive/specular reflections, which led to the Bosanquet formula for the bacterial diffusion coefficient. Based on the experimental observation that bacterial swimming motion is guided by a straight tube, the second approach considered modifications in the bacterial swimming orientation as a consequence of various long-range interactions with the tube surface. A phenomenological turning model capable of aligning bacterial motion along a tube axis was proposed. The model predicts that under the geometrical restriction of a small cylindrical tube, the macroscopic bacterial transport resulting from the proposed turning model can exhibit behavior that ranges from dimensionally reduced diffusion to pure wave propagation, depending on the influence of the tube diameter on the reversal probability in the bacterial swimming motion. Our theoretical model provides explicit equations that explain how such a transition can occur. The predicted results were then qualitatively compared with experimental data from the literature. As a preliminary comparison, we concluded that bacterial transport in cylindrical tubes of diameter 10 micrometers remains in the mode of a dimensionally reduced diffusion, and shifts to a wave motion when the tube diameter decreases to 6 micrometers.     

Toward optimal health: the experts discuss tamoxifen and breast cancer prevention. Interview by Jodi Godfrey Meisler

Retinoids are commonly used for the treatment of nonmalignant skin disorders and occasionally for the treatment of various neoplasms including epidemic Kaposi sarcoma (KS). Dry skin and mucus membranes, muscle and joint aches, alopecia, headaches, and liver and lipid abnormalities are the most frequent medication-related side effects. Very rarely, this class of drugs is associated with the development of hypercalcemia. The authors report the case of a man with acquired immunodeficiency syndrome (AIDS)-associated KS who, while participating in a phase II clinical trial of LGD 1057 (9-cis-retinoic acid) for treatment of epidemic KS, developed hypercalcemia, mental status changes, and renal insufficiency. The etiologic factors of retinoid-induced hypercalcemia are imperfectly understood, but with drug withdrawal his serum calcium, mental acuity, and renal function quickly normalized. Hypercalcemia occurs infrequently in the setting of AIDS and when present, is usually mediated by opportunistic infections. Clinicians should be alert to this potentially life-threatening iatrogenic complication that responds favorably to drug withdrawal.     

Assessment of personal goal hierarchies.

Developed a method for measuring goal heirarchies using an in-depth interview procedure with 25 male college seniors and 28 male blue-collar workers (aged 55–62 yrs). Ss were asked to describe (1) what they wanted out of life, (2) their daily activities, and (3) their goals in 6 domains of life: family, work and school, social life, leisure, personal growth, material, and other. A coding system was then used for constructing an Adult Intentional and Motivational Systems Chart for each Ss, using dimensions including life domain, level of generality, and means–end connections. Results indicate that people are aware of personal goals and satisfactions that guide their behavior. Evidence of validity and reliability suggest the continued use of the chart for research on self-direction and adult development as well as intervention efforts. Also, Ss who viewed their charts considered them to be accurate. (45 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Glow discharge beam techniques

The cathode fall region of the glow discharge contains fast electrons and fast ions which are accelerated in the electric field between the cathode and a plasma at near anode potential. When operated at low pressure and high voltage (i.e. on the left-hand branch of the Paschen breakdown curve), the fast electrons tend to form a mono-energetic group, although the ions, owing to relatively large cross-sections for interaction with the gas, have their energies spread over a wide range and also give rise to fast neutrals by charge exchange. Both types of particle can be efficiently brought out of the discharge through orifices placed in the electrodes. Thin or broad beams or sheets of particles, converging or diverging, can be designed over a wide range of current and voltage. At lower voltages, electron beams may be applied to a target placed within the discharge. As the voltage is increased, extracted electron beams become penetrating and can be manipulated magnetically outside the discharge. The gas pressure required for operation depends on the gas, the anode to cathode distance, and voltage and current. By appropriate design, operation at a pressure of about 100 m or more can usually be arranged thus demanding only the simplest vacuum techniques.Both electron and ion beams may be applied to insulating materials as well as conducting materials. This is possible because electrical charging difficulties are avoided owing to the associated presence of ionised gas. A number of different types of glow discharge gun of novel design have been constructed and their characteristics investigated. This paper discusses the design principles employed and illustrates applications in the fields of crystal growing, vapour deposition, welding, thermal milling and etching and milling by sputtering.     

L-Shell Ionization in Proton and Alpha Particle Collisions with Argon

We report results of coupled-state calculations of argon L-shell ionization by proton and alpha particle collisions in the 100 to 500 kev/amu energy range. Our target-centered basis includes up through f-states. We have explored the angular momentum convergence and ability of our pseudostates to describe the ionization continuum by comparing to the Born calculations of Choi; excellent agreement is obtained. In the Born we have shown the effect of using different independent-particle target potentials; these effects are large, particularly at low energy. We propose a modification of the Hartree-Fock potential that leaves all the wavefunctions and the bound orbital energies unaltered, but that lowers the continuum by an amount that brings the L-shell ionization potentials roughly into agreement with experiment. Our coupled-states calculations show deviations from the 1st Born approximation, and are in fair agreement with experiment. A complete comparison to experiment will require the calculation of the charge transfer channel contribution to the vacancy production.     

Cadmium sulfide and cadmium selenide/cadmium sulfide nanoparticles stabilized in water with poly(cysteine acrylamide)

Cysteine acrylamide (N-acryloyl L-cysteine) stabilizes CdS nanoparticles as the particles form in aqueous dispersions. Cysteine acrylamide also exchanges for citrate on the surfaces of CdSe and core/shell CdSe/CdS nanoparticles to provide greater stability. Heating of the nanoparticle dispersions polymerizes the cysteine acrylamide on the surface to form a more efficient polydentate stabilizer. The polymer-coated nanoparticle dispersions are colloidally stable even after removal of low molecular weight solutes by dialysis. Emission quantum yields of the polymer-coated CdSe and CdSe/CdS samples were 0.9% and 2.6%, respectively, after aging of the samples in light. CdSe/CdS coated with poly(cysteine acrylamide) is colloidally stable for at least two years in the dark at 5 degrees C.     

Associative influence on the foraging behavior of pigeons (Columba livia).

In laboratory simulations of foraging conditions, adult White Carneaux pigeons maintained ad lib weight by treadlepressing for lengthy periods of access to grain in a 24-hr live-in environment. Localized visual signals produced by treadlepressing evoked approach and pecking behavior if they signaled impending food presentation (Pavlovian 1st-order conditioning) or the presentation of an established signal for food (Pavlovian 2nd-order conditioning). Findings from the 2 studies imply a role for associative mechanisms in the control of foraging. (44 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Degradation of PCBs in a marine sediment treated with ionizing and UV radiation

Radiolytic (electron beam) and photolytic (ultraviolet, UV) dechlorination of polychlorinated biphenyls (PCBs) in a marine sediment are described. Samples of a PCB-laden marine sediment, Standard Reference Material (SRM) 1944, NewYork/New Jersey Waterway Sediment, have been mixed with aqueous alcohol solutions and irradiated with an electron beam or photolyzed. Additives, such as alcohol, enhance the radiolytic yield and PCB dechlorination. In the electron beam irradiated samples, the concentrations of 29 PCB congeners decrease with irradiation dose. At the highest dose (500 kGy), the total concentration of PCBs is decreased by 83%. Photolysis leads to little dechlorination, but photolysis with added triethylamine leads to dechlorination (about 60%). It is likely that photolysis under optimal conditions (other additives, exposure time) may be as effective as electron beam radiolysis for the dechlorination of PCBs in sediment.