Vapor‐induced swelling of supported methacrylic and siloxane polymer films: Determination of interaction parameters

White light reflectance spectroscopy is applied to monitor vapor‐induced thickness changes of polymer films, supported on suitable silicon substrates. Assuming unidirectional swelling due to the constraining support, the equilibrium volume swelling of four methacrylic polymers and two siloxane‐based copolymers upon exposure to various activities of water, methanol, ethanol, and ethyl acetate vapor, at 30°C is evaluated. The deduced sorption isotherms were fitted to the Flory‐Huggins equation and interaction parameters, as well as solubility coefficients at infinite solute dilution, were deduced for each binary system. The relative sorption capacity of the different classes of polymers toward the four vapors are in line with the expected solubility interactions between solvent and solute. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

An Integrated Approach for the Estimation of Mobile Subscriber Geolocation

The continuous growth of wireless services market, fuels the need for precise location dependent services, leading researchers from academia and industry to reassess existing geolocation methods regarding accuracy and availability of position estimation. The proposed method for mobile subscriber geolocation utilizes key concepts from estimation theory and specifically the Kalman filter algorithm to determine an optimal estimate on the actual system state (which primarily includes location, velocity) based on the observations acquired by employing network- or terminal-based techniques, which are briefly presented and assessed thereafter. Given the proven limitations of individual techniques, the alternative strategies for fusion of data are outlined, the details of the operation of a fusion scheme based on the Kalman filter are discussed and the impact of the proposed work over conventional methodologies is quantified.     

Tesile toughness of microcellular foams of polystyrene,styrene-acrylonitrile copolymer,and polycarbonate,and the effect of dissolved gas on the tensile toughness of the same polymer matrices and microcellular foams

This paper reports on the tensile properties of microcellular foams of three different thermoplastics, since there have been several reports in the literature, but with indefinite conclusions so far, that microbubbles act in a manner similar to rubber particles in toughening thermoplastics. Polystyrene (PS), styreneacrylonitrile copolymer (SAN), and polycarbonate (PC), were selected based on their different intrinsic ductilities. The gas supersaturation technique was used to generate samples with microbubbles. The effect of the presence of microbubbles inside the polymer matrix was separated from the effects of the pressure and thermal history experienced by the samples. Nitrogen gas dissolved into PS, and to a lesser extent into SAN, caused and increase of the tensile toughness, but this increased decayed with time as nitrogen gas diffused out of the samples. Furthermore, microcellularly foamed PS samples showed some limited improvement in terms of tensile toughness after all the nitrogen gas diffused out. SAN and PC showed deterioration of the tensile toughness in the presence of microbubbles.     

Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein

Serum soluble interleukin-6 receptor (sIL-6R) concentrations were measured in 52 patients with multiple myeloma (MM) and 24 normal controls, using a commercially available immunoenzymatic assay kit. Patients were staged according to the Bataille et al. myeloma staging system based on the levels of patients' serum beta 2-microglobulin and C-reactive protein. Twenty-one patients were at stage A of disease, 19 at stage B and 12 at stage C at the time of serum collection for sIL-6R determination. Serum sIL-6R concentrations ranged from 15 to 176 ng/ml with a mean of 64.8 +/- 35.9 ng/ml and a median of 58 ng/ml in the entire group of patients studied. These values were significantly higher than those of 34.4 +/- 13.4 ng/ml found in the controls (P < or = 0.001). Patients of stage C had higher sIL-6R levels (94.8 + 41.2 ng/ml) than patients of stage B (67.7 +/- 31.0 ng/ml) (P < 0.01), and markedly higher than patients of stage A (45.0 +/- 23.1 ng/ml) (P < 0.001). Serum levels of sIL-6R in patients with stage A disease did not differ statistically from those of the controls. A linear positive correlation was observed between serum levels of the receptor and the stage of MM (r = 0.539, P < 0.001). These data strongly suggest that serum sIL-6R concentrations correlate with the stages of MM and may be used as an indicator of the activity of the disease.     

Impaired release of natural killer cytotoxic factor(s) by peripheral blood lymphocytes in patients with chronic LGL-proliferative disease

BACKGROUND: Chronic LGL-proliferative disease (LGL-PD) is a clonal expansion of cells with large granular lymphocyte (LGL) morphology. In most cases, proliferating cells express both suppressor/cytolytic T-cell and natural killer (NK) cell surface markers, but other cell phenotypes may be observed. LGL-PD lymphocytes have been found to lack or show very low natural killer cell activity (NKa). The aim of the present paper is to investigate the underlying mechanisms responsible for impaired NKa in a homogeneous group of five selected LGL-PD patients with a CD3+, CD8+, CD57+ cell phenotype. RESULTS: In all patients, the expanded cell population expressed very low NKa against K562 cell targets, but this increased significantly with recombinant human interleukin-2 (rhIL-2) and phytohemagglutinin (PHA) activation. Recombinant human alpha-interferon (rhIFN-alpha) had no significant effect on NKa. Cells displayed normal tumor cell binding capacity but failed to release sufficient amounts of functionally active natural killer cytotoxic factor(s) (NKCFs) upon interaction with the NK-sensitive K562 cells targets. However, they did release soluble cytolytic molecules against K562 cells upon activation with PHA. CONCLUSIONS: Our findings provide evidence that the defective NKa in LGL-PD patients with the aforementioned phenotype is probably due, at least in part, to the inability of expanded lymphocytes to release NKCFs upon interaction with NK-sensitive cell targets. Since recognition of target cells by patient lymphocytes is not disturbed and the cells are capable of producing NKCFs upon activation with PHA, it is probable that the cause of this abnormality is located at the level of the activation signal provided by the stimulatory target cells. Studies in subcellular level are certainly needed for a more precise determination of the underlying defect.     

Geostatistical analysis of spatial variability of rainfall and optimal design of a rain gauge network

Kriging is a geostatistical estimation technique for regionalized variables that exhibit an autocorrelation structure. Such a structure can be described by a semivariogram of the observed data. The punctual-kriging estimate at any point is a weighted average of the data, where the weights are determined by using the semivariogram and an assumed drift, or lack of drift, in the data. The kriging algorithm, based on unbiased and minimum-variance estimates, involves a linear system of equations to calculate the weights. Kriging is applied in an attempt to describe the spatial variability of rainfall data over a geographical region in northern Greece. Monthly rainfall data of January and June 1987 have been taken from 20 measurement stations throughout the above area. The rainfall data are used to compute semivariograms for each month. The resulting semivariograms are anisotropic and fitted by linear and spherical models. Kriging estimates of rainfall and standard deviation were made at 90 locations covering the study area in a rectangular grid and the results used to plot contour maps of rainfall and contour maps of kriging standard deviation. Verification of the kriging estimates of rainfall are made by removing known data points and kriging an estimate at the same location. This verification is known as the jacknifing technique. Kriging errors, a by-product of the calculations, can then be used to give confidence intervals of the resulting estimates. The acceptable results of the verification procedure demonstrated that geostatistics can be used to describe the spatial variability of rainfall. Finally, it is shown how the property of kriging variance depends on the structure and the geometric configuration of the data points and the point to be estimated can also be used for the optimal design of the rain gauge network in an area.     

Development and testing of a high precision digital Gaussian generator for Computers

A high precision generator of Gaussian distributed pseudorandom numbers has been developed and tested. The generator is designed so that to be suitable for use with computers in simulation applications. Experimental results are given which verify the theoretically predicted performance. The generator approximates with high accuracy the tails of the Gaussian density and this makes it suitable for simulations of rare events. Depending on the system parameters the originally generated densities can be produced in a form which allows computer scaling without affecting the accuracy over a range of more than $\text{+5}$ standard deviations from the mean.