一种基于低温多晶硅TFT技术的柔性8位异步微处理器

介绍基于低温多晶硅TFT技术和采用激光退火表面刻蚀技术的柔性8位异步微处理器,并且给出了异步电路描述语言Verilog 。32,000个晶体管的微处理器在500kHz,5V的条件下消耗电流180mA,功耗是同步微处理器的30%。     

The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast

Translation termination in eukaryotes requires a codon-specific (class-I) release factor, eRF1, and a GTP/GDP-dependent (class-II) release factor, eRF3. The model of "molecular mimicry between release factors and tRNA" predicts that eRF1 mimics tRNA to read the stop codon and that eRF3 mimics elongation factor EF-Tu to bring eRF1 to the A site of the ribosome for termination of protein synthesis. In this study, we set up three systems, in vitro affinity binding, a yeast two-hybrid system, and in vitro competition assay, to determine the eRF3-binding site of eRF1 using the fission yeast Schizosaccharomyces pombe proteins and creating systematic deletions in eRF1. The in vitro affinity binding experiments demonstrated that the predicted tRNA-mimicry truncation of eRF1 (Sup45) forms a stable complex with eRF3 (Sup35). All three test systems revealed that the most critical binding site is located at the C-terminal region of eRF1, which is conserved among eukaryotic eRF1s and rich in acidic amino acids. To our surprise, however, the C-terminal deletion eRF1 seems to be sufficient for cell viability in spite of the severe defect in eRF3 binding when expressed in a temperature-sensitive sup45 mutant of the budding yeast, Saccharomyces cerevisiae. These results cannot be accounted for by the simple "eRF3-EF-Tu mimicry" model, but may provide new insight into the eRF3 function for translation termination in eukaryotes.     

On H/sub /spl infin// model reduction using LMIs

In this note, we deal with the problem of approximating a given nth-order linear time-invariant system G by an rth-order system G/sub r/ where r相似文献   

Effect of E4031, a class III antiarrhythmic drug, on ischemia- and reperfusion-induced arrhythmias in isolated rat hearts

With the onset of vitellogenesis, the follicular epithelium overlying the oocyte in stick insect ovarioles becomes highly polarized and patent by formation of wide intercellular spaces. The aim of the present study was to provide experimental support to the notion that the follicular epithelium in this insect species may be involved in transcytosis. Data demonstrate that the follicular epithelium carries out sulfo-conjugation of a 85 kDa fat body derived protein by allowing it ot transit from one cell pole to another. Along the basal end, follicle cells branch into a number of cytoplasmic finger-like projections. At the opposite end facing the oocyte they taper off into lance-head shapes. Different vesicular elements are evident at both these extremities. In vivo exposure to horseradish peroxidase shows that the vesicular elements present along the apical end provide an endocytic entry. In contrast, those present along the basal end are labeled with sodium [35S]-sulfate, suggesting that they may be exocytic vesicles containing a sulfo-conjugated secretory product. In vivo exposure to sodium [35S]-sulfate caused radioactivity to appear over the Golgi apparatus and some nearby vesicles of the follicle cell cytoplasm, including the exocytic vesicles. The intracellular pathway of the follicle cells was also examined by immunogold labeling using a monoclonal antibody raised against a 85 kDa fat body derived protein. Under these conditions, gold particles were consistently detected over the Golgi apparatus and the vesicular elements lying along both poles of the follicle cell membrane. Based on this evidence, it is concluded that follicular cells in stick insect ovarioles are endowed with the ability to undergo transcytosis by providing an endocytic entry along the apical end and by releasing exocytically a sulfo-conjugated 85 kDa protein along the baso-lateral domain of the follicle cell membrane.     

Chronopharmacology of furosemide in the elderly

The authors have previously reported the time-dependent change in the diuretic effects of furosemide, a loop diuretic agent, in young and middle-aged subjects. The current study was undertaken to examine an influence of aging on this chronopharmacologic phenomenon. Ten milligrams furosemide was given intravenously to 12 elderly subjects (greater than 70 years of age) at 9:00 AM (day trial) or at 9:00 PM (night trial) by a cross-over design. One-hour urine samples were collected for 3 hours after each administration, and urine volume and urinary excretions of sodium and furosemide were determined. Urine volume and urinary sodium excretion increased after furosemide administration. Contrary to the findings in the young and middle-aged subjects, no significant differences were observed in these parameters at any observation period between the day and night trials in the elderly subjects. Urinary furosemide excretion of the day and night trials did not significantly differ. These results suggest that the chronopharmacologic profiles of furosemide are altered in the elderly.     

An evaluation of the endurance of chromized and plated chromium coatings in a hot gas erosion atmosphere

A comparison was made of the endurance of plated chromium and chromized coatings in a high temperature erosion atmosphere, produced by burning propellants in an erosion test apparatus. The substrate materials used for these coatings were a nickel-base alloy (Inconel 718), an FeNi-base alloy (CG-27), H11 tool steel and CrMoV steel. The erosivity was obtained from weight loss determinations. Chromizing provides a better erosion-resistant surface for Inconel 718 than chromium plating does, whereas chromium plating provides a better resistance to erosion for CG-27, H11 and CrMoV steels than chromizing does. Optical metallography, scanning electron microscopy and energy-dispersive analysis with X-rays confirm these findings.     

Resonance analysis of a circular dipole array antenna in cylindrically layered media for directional borehole radar

In this paper, we discuss the influence of a resonance on estimating direction of arrival (DOA) with a circular dipole array in a borehole (CAB). The resonance is caused by the phase-sequence of currents on the dipole antennas. Making use of method of moments (MoM) analysis, we predict resonant frequencies of the CAB and describe a mechanism for the resonance theoretically, making use of the fact that a plane wave can be broken down into cylindrical harmonics. In order to examine the agreement between the MoM and experimental data, we propose a signal processing method to extract phase-sequence components from the actual received array signal. This method is useful for confirming excitation of the phase-sequence resonance in experimental data, as predicted by the MoM. Using the MoM, we examine the influence of the resonances on DOA estimation, and we conclude that the resonances give some spurious solutions. In order to confirm these results, we conduct experiments at a field test site. We arrange the CAB, which consisted of seven receiving dipole antennas. In this experiment, a plane wave is incident on the CAB from a transmitter in another borehole. We apply the proposed signal method, and the measured results demonstrate the existence of the phase-sequence resonance in a physically real CAB. The spurious solutions found to occur in the DOA estimation at the resonant frequencies are also found experimentally.     

Digestibility, fermentability, and energy value of highly cross-linked phosphate tapioca starch in men

The objective of this study was to determine glycemic and breath hydrogen responses in 10 healthy men in response to highly cross-linked starch phosphate (HXLS), made of tapioca starch (TS). Plasma glucose concentration was analyzed at baseline and at 30, 60, 90, 120, 150, and 180 min postprandially. In addition, breath hydrogen excretion was measured at baseline and at hourly intervals, over 10 h, after test substance challenge. When compared with unmodified TS easily digested, the area under the curve of plasma glucose of HXLS was 64% smaller, and was almost the same as that of microcrystalline cellulose. When compared with fructo-oligosaccharide rapidly fermented by the microbial bacteria, the area under the excretion curve of breath hydrogen gas of HXLS was 93% smaller, and was almost the same as that of water only. These results show that HXLS is harder to digest and ferment than unmodified TS in men.     

Comparison of multiple prompt γ-ray analysis and prompt γ-ray analysis for the elemental analysis of geological and cosmochemical samples

Multiple prompt γ-ray analysis (MPGA) and conventional neutron-induced prompt γ-ray analysis (PGA) are nondestructive analytical methods for bulk chemical compositions, and their analytical capabilities were compared for elemental analyses of geological and cosmochemical samples. Detection sensitivities of PGA are often restricted by poor signal-to-noise ratios and interferences from different origins. MPGA can substantially reduce the background level, especially for hydrogenous samples, relative to PGA, which opens up a possibility to use lower energy prompt γ-rays of some trace elements. Although it is one of the major constituent elements of rock samples, Mg is hard to be determined by PGA. With MPGA, Mg contents could be determined with reasonable consistency with their corresponding recommended values in geological and cosmochemical samples by carefully selecting suitable coincident prompt γ-ray energy pairs without interference correction. MPGA was applied to a hydrogenous meteorite, Ivuna, which contains H at 2% mass level. MPGA detection limits for most of the elements studied can be reduced up to 1 order of magnitude when compared with PGA detection limits under the present experimental conditions.     

提高甘薯淀粉中抗消化淀粉含量的技术研究

抗消化淀粉是一种具有保健功能作用的淀粉,老化淀粉是制备抗消化淀粉最主要的方法.本文研究了酶水解预处理和冷冻解冻循环处理对甘薯老化淀粉中抗消化淀粉形成的影响,得到了提高甘薯淀粉中抗消化淀粉含量的适宜的工艺路线和参数,即：先用300U/g淀粉的普鲁兰酶水解2h,再用10U/g淀粉的α-淀粉酶水解0.5h,浓度为12%的酶处理淀粉胶在4℃条件下老化20h后,再经冷冻（-20℃,2h）-解冻（50℃,30min）-老化（4℃,6h）循环处理3次,淀粉中RS含量可达31.21%.实验结果表明,甘薯淀粉通过普鲁兰酶和α-淀粉酶复合水解处理和冷冻解冻循环处理能明显提高老化淀粉中抗消化淀粉的含量.